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Physical and dosimetric characterization of thermoset shape memory bolus developed for radiotherapy.

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Title: Physical and dosimetric characterization of thermoset shape memory bolus developed for radiotherapy.
Authors: Aoyama, Takahiro1,2 (AUTHOR) aoyamat@aichi-cc.jp, Uto, Koichiro3 (AUTHOR), Shimizu, Hidetoshi1 (AUTHOR), Ebara, Mitsuhiro3 (AUTHOR), Kitagawa, Tomoki1 (AUTHOR), Tachibana, Hiroyuki1 (AUTHOR), Suzuki, Kojiro4 (AUTHOR), Kodaira, Takeshi1 (AUTHOR)
Source: Medical Physics. Dec2020, Vol. 47 Issue 12, p6103-6112. 10p.
Subjects: Bolus radiotherapy, Memory, Shape memory polymers, Quality control, Water use
Abstract: Purpose: We developed a thermoset shape memory bolus (shape memory bolus) made from poly‐ε‐caprolactone (PCL) polymer. This study aimed to investigate whether the shape memory bolus can be applied to radiotherapy as a bolus that conformally adheres to the body surface, can be created in a short time, and can be reused. Methods: The shape memory bolus was developed by cross‐linking tetrabranch PCL with reactive acrylate end groups. Dice similarity coefficient (DSC) was used to evaluate shape memory characterization before deformation and after restoration. In addition, the degree of adhesion to the body surface and crystallization time were calculated. Moreover, dosimetric characterization was evaluated using the water equivalent phantom and an Alderson RANDO phantom. Results: The DSC value between before deformation and after restoration was close to 1. The degree of adhesion of the shape memory bolus (1.9%) was improved compared with the conventional bolus (45.6%) and was equivalent to three‐dimensional (3D) printer boluses (1.3%–3.5%). The crystallization time was approximately 1.5 min, which was clinically acceptable. The dose calculation accuracy, dose distribution, and dose index were the equivalent compared with 3D boluses. Conclusion: The shape memory bolus has excellent adhesion to the body surface, can be created in a short time, and can be reused. In addition, the shape memory bolus needs can be made from low‐cost materials and no quality control systems are required for individual clinical departments, and it is useful as a bolus for radiotherapy. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Physical and dosimetric characterization of thermoset shape memory bolus developed for radiotherapy.
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  Data: <searchLink fieldCode="AR" term="%22Aoyama%2C+Takahiro%22">Aoyama, Takahiro</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> aoyamat@aichi-cc.jp</i><br /><searchLink fieldCode="AR" term="%22Uto%2C+Koichiro%22">Uto, Koichiro</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shimizu%2C+Hidetoshi%22">Shimizu, Hidetoshi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ebara%2C+Mitsuhiro%22">Ebara, Mitsuhiro</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kitagawa%2C+Tomoki%22">Kitagawa, Tomoki</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tachibana%2C+Hiroyuki%22">Tachibana, Hiroyuki</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suzuki%2C+Kojiro%22">Suzuki, Kojiro</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kodaira%2C+Takeshi%22">Kodaira, Takeshi</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Dec2020, Vol. 47 Issue 12, p6103-6112. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Bolus+radiotherapy%22">Bolus radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Shape+memory+polymers%22">Shape memory polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+control%22">Quality control</searchLink><br /><searchLink fieldCode="DE" term="%22Water+use%22">Water use</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: We developed a thermoset shape memory bolus (shape memory bolus) made from poly‐ε‐caprolactone (PCL) polymer. This study aimed to investigate whether the shape memory bolus can be applied to radiotherapy as a bolus that conformally adheres to the body surface, can be created in a short time, and can be reused. Methods: The shape memory bolus was developed by cross‐linking tetrabranch PCL with reactive acrylate end groups. Dice similarity coefficient (DSC) was used to evaluate shape memory characterization before deformation and after restoration. In addition, the degree of adhesion to the body surface and crystallization time were calculated. Moreover, dosimetric characterization was evaluated using the water equivalent phantom and an Alderson RANDO phantom. Results: The DSC value between before deformation and after restoration was close to 1. The degree of adhesion of the shape memory bolus (1.9%) was improved compared with the conventional bolus (45.6%) and was equivalent to three‐dimensional (3D) printer boluses (1.3%–3.5%). The crystallization time was approximately 1.5 min, which was clinically acceptable. The dose calculation accuracy, dose distribution, and dose index were the equivalent compared with 3D boluses. Conclusion: The shape memory bolus has excellent adhesion to the body surface, can be created in a short time, and can be reused. In addition, the shape memory bolus needs can be made from low‐cost materials and no quality control systems are required for individual clinical departments, and it is useful as a bolus for radiotherapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Shape memory polymers
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      – SubjectFull: Quality control
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              M: 12
              Text: Dec2020
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