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Construction of a specific and efficient antibacterial agent against Pseudomonas aeruginosa based on polyethyleneimine cross-linked fucose.

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Title: Construction of a specific and efficient antibacterial agent against Pseudomonas aeruginosa based on polyethyleneimine cross-linked fucose.
Authors: Liu, Mei1,2 (AUTHOR) liumei@snnu.edu.cn, Guo, Rong2 (AUTHOR), Ma, Yue2 (AUTHOR)
Source: Journal of Materials Science. 2021, Vol. 56 Issue 10, p6083-6094. 12p. 2 Color Photographs, 1 Black and White Photograph, 1 Chart, 7 Graphs.
Subjects: Bacterial cell walls, Antibacterial agents, Fucose, Polyethyleneimine, Pseudomonas aeruginosa
Abstract: Polyethyleneimine (PEI) is known for its antibacterial properties and ease of modification. How to improve the specific antibacterial activity of PEI with low toxicity is a research hotspot. In this work, the PEI was used to synthesize a fucose-modified polyethyleneimine copolymer particles (Fuc-PEI CPs) via nucleophilic addition between primary amine and aldehyde groups. Fucose (Fuc) can capture Pseudomonas aeruginosa (P. aeruginosa) with LecB, which has a good targeting property toward P. aeruginosa. The Fuc-PEI CPs' antibacterial activity was investigated by plate counting method. Compared with unmodified PEI, Fuc-PEI CPs (2.5 μg/mL) showed unique bactericidal ability against P. aeruginosa, and less cytotoxicity and excellent biocompatibility. The antimicrobial mechanism indicated that the improvement of PEI antibacterial activity against P. aeruginosa ascribed to the Fuc's unique recognition of bacteria and PEIs' ability to destroy the cell membrane of bacteria. The Fuc-PEI CPs as a new antibacterial agent shed light on the constructing a novel antibacterial pathway for killing P. aeruginosa. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Materials Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Label: Title
  Group: Ti
  Data: Construction of a specific and efficient antibacterial agent against Pseudomonas aeruginosa based on polyethyleneimine cross-linked fucose.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Mei%22">Liu, Mei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> liumei@snnu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Guo%2C+Rong%22">Guo, Rong</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Yue%22">Ma, Yue</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%22">Journal of Materials Science</searchLink>. 2021, Vol. 56 Issue 10, p6083-6094. 12p. 2 Color Photographs, 1 Black and White Photograph, 1 Chart, 7 Graphs.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Bacterial+cell+walls%22">Bacterial cell walls</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Fucose%22">Fucose</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethyleneimine%22">Polyethyleneimine</searchLink><br /><searchLink fieldCode="DE" term="%22Pseudomonas+aeruginosa%22">Pseudomonas aeruginosa</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Polyethyleneimine (PEI) is known for its antibacterial properties and ease of modification. How to improve the specific antibacterial activity of PEI with low toxicity is a research hotspot. In this work, the PEI was used to synthesize a fucose-modified polyethyleneimine copolymer particles (Fuc-PEI CPs) via nucleophilic addition between primary amine and aldehyde groups. Fucose (Fuc) can capture Pseudomonas aeruginosa (P. aeruginosa) with LecB, which has a good targeting property toward P. aeruginosa. The Fuc-PEI CPs' antibacterial activity was investigated by plate counting method. Compared with unmodified PEI, Fuc-PEI CPs (2.5 μg/mL) showed unique bactericidal ability against P. aeruginosa, and less cytotoxicity and excellent biocompatibility. The antimicrobial mechanism indicated that the improvement of PEI antibacterial activity against P. aeruginosa ascribed to the Fuc's unique recognition of bacteria and PEIs' ability to destroy the cell membrane of bacteria. The Fuc-PEI CPs as a new antibacterial agent shed light on the constructing a novel antibacterial pathway for killing P. aeruginosa. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Materials Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10853-020-05653-9
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 6083
    Subjects:
      – SubjectFull: Bacterial cell walls
        Type: general
      – SubjectFull: Antibacterial agents
        Type: general
      – SubjectFull: Fucose
        Type: general
      – SubjectFull: Polyethyleneimine
        Type: general
      – SubjectFull: Pseudomonas aeruginosa
        Type: general
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      – TitleFull: Construction of a specific and efficient antibacterial agent against Pseudomonas aeruginosa based on polyethyleneimine cross-linked fucose.
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            NameFull: Liu, Mei
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            NameFull: Guo, Rong
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            NameFull: Ma, Yue
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            – D: 01
              M: 05
              Text: 2021
              Type: published
              Y: 2021
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            – TitleFull: Journal of Materials Science
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