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Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.

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Title: Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.
Authors: Rezvani Habibabadi, Roya1 (AUTHOR), Khoshpouri, Pegah1 (AUTHOR), Ghadimi, Maryam1 (AUTHOR), Shaghaghi, Mohammadreza1 (AUTHOR), Ameli, Sanaz1 (AUTHOR), Hazhirkarzar, Bita1 (AUTHOR), Pandey, Pallavi1 (AUTHOR), Aliyari Ghasabeh, Mounes1 (AUTHOR), Pandey, Ankur1 (AUTHOR), Kamel, Ihab R.1 (AUTHOR) ikamel@jhmi.edu
Source: European Radiology. 2020, Vol. 30 Issue 3, p1609-1615. 7p. 1 Color Photograph, 4 Charts, 4 Graphs.
Subjects: Ultrasonic imaging, Liver, Elasticity, Cirrhosis of the liver, Magnetic resonance imaging, Retrospective studies, Algorithms
Abstract: Objectives: This study was conducted to quantify the heterogeneity of liver stiffness (LS) on MR elastography (MRE) by comparing ROI-based and volumetric measurements.Methods: LS was measured by ROI-based and volumetric segmentation of the liver parenchyma. Mean LS (MLS) was calculated and used to assign stages of fibrosis. Volumetric measurements of stiffness maps were used to determine the percentage of liver volume above/below MLS and presence of LS heterogeneity. Heterogeneous stiffness was defined when the first and second most predominant stages were more than one category apart. MLS values by each method were compared using the Wilcoxon signed-rank test.Results: We included 128 patients with suspected liver fibrosis (mean age 54.4 ± 14.8 years). MLS was 2.7 ± 1.0 kPa for ROI measurements and 2.6 ± 0.9 kPa for the volumetric method (p = 0.001). Of 59 patients with normal stage (F0), 31 patients (52.5%) had > 20% of liver volume with abnormal LS (F1-F4). Heterogeneous LS was reported in 18 patients (14%).Conclusions: MLS measurement may not represent the entire spectrum of hepatic fibrosis. Volumetric segmentation may potentially improve the detection of heterogeneous fibrosis and the accuracy of LS measurement.Key Points: • Heterogeneity of hepatic fibrosis may occur in patients with chronic liver disease. • MR elastography is used to assess hepatic fibrosis by measuring liver stiffness. • Measuring liver stiffness by the ROI method and reporting a mean value may fail to detect heterogeneity of hepatic fibrosis. Volumetric assessment of liver stiffness by MR elastography may detect heterogeneity of parenchymal involvement. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.
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  Data: <searchLink fieldCode="AR" term="%22Rezvani+Habibabadi%2C+Roya%22">Rezvani Habibabadi, Roya</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khoshpouri%2C+Pegah%22">Khoshpouri, Pegah</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghadimi%2C+Maryam%22">Ghadimi, Maryam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shaghaghi%2C+Mohammadreza%22">Shaghaghi, Mohammadreza</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ameli%2C+Sanaz%22">Ameli, Sanaz</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hazhirkarzar%2C+Bita%22">Hazhirkarzar, Bita</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pandey%2C+Pallavi%22">Pandey, Pallavi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aliyari+Ghasabeh%2C+Mounes%22">Aliyari Ghasabeh, Mounes</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pandey%2C+Ankur%22">Pandey, Ankur</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kamel%2C+Ihab+R%2E%22">Kamel, Ihab R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ikamel@jhmi.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. 2020, Vol. 30 Issue 3, p1609-1615. 7p. 1 Color Photograph, 4 Charts, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ultrasonic+imaging%22">Ultrasonic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Liver%22">Liver</searchLink><br /><searchLink fieldCode="DE" term="%22Elasticity%22">Elasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Cirrhosis+of+the+liver%22">Cirrhosis of the liver</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Algorithms%22">Algorithms</searchLink>
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  Data: <bold>Objectives: </bold>This study was conducted to quantify the heterogeneity of liver stiffness (LS) on MR elastography (MRE) by comparing ROI-based and volumetric measurements.<bold>Methods: </bold>LS was measured by ROI-based and volumetric segmentation of the liver parenchyma. Mean LS (MLS) was calculated and used to assign stages of fibrosis. Volumetric measurements of stiffness maps were used to determine the percentage of liver volume above/below MLS and presence of LS heterogeneity. Heterogeneous stiffness was defined when the first and second most predominant stages were more than one category apart. MLS values by each method were compared using the Wilcoxon signed-rank test.<bold>Results: </bold>We included 128 patients with suspected liver fibrosis (mean age 54.4 ± 14.8 years). MLS was 2.7 ± 1.0 kPa for ROI measurements and 2.6 ± 0.9 kPa for the volumetric method (p = 0.001). Of 59 patients with normal stage (F0), 31 patients (52.5%) had > 20% of liver volume with abnormal LS (F1-F4). Heterogeneous LS was reported in 18 patients (14%).<bold>Conclusions: </bold>MLS measurement may not represent the entire spectrum of hepatic fibrosis. Volumetric segmentation may potentially improve the detection of heterogeneous fibrosis and the accuracy of LS measurement.<bold>Key Points: </bold>• Heterogeneity of hepatic fibrosis may occur in patients with chronic liver disease. • MR elastography is used to assess hepatic fibrosis by measuring liver stiffness. • Measuring liver stiffness by the ROI method and reporting a mean value may fail to detect heterogeneity of hepatic fibrosis. Volumetric assessment of liver stiffness by MR elastography may detect heterogeneity of parenchymal involvement. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-019-06478-0
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      – SubjectFull: Elasticity
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