Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid–Structure Interaction Approach.
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| Title: | Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid–Structure Interaction Approach. |
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| Authors: | Emendi, Monica1,2 (AUTHOR), Sturla, Francesco3 (AUTHOR), Ghosh, Ram P.2 (AUTHOR), Bianchi, Matteo2 (AUTHOR), Piatti, Filippo3 (AUTHOR), Pluchinotta, Francesca R.1,4,5 (AUTHOR), Giese, Daniel6 (AUTHOR), Lombardi, Massimo4 (AUTHOR), Redaelli, Alberto1 (AUTHOR), Bluestein, Danny2 (AUTHOR) danny.bluestein@stonybrtook.edu |
| Source: | Annals of Biomedical Engineering. 2021, Vol. 49 Issue 2, p627-641. 15p. |
| Subjects: | Mitral valve, Fluid-structure interaction, Aortic valve, Magnetic resonance imaging, Hemodynamics, Jets (Fluid dynamics), Biomechanics |
| Abstract: | Congenital bicuspid aortic valve (BAV) consists of two fused cusps and represents a major risk factor for calcific valvular stenosis. Herein, a fully coupled fluid–structure interaction (FSI) BAV model was developed from patient-specific magnetic resonance imaging (MRI) and compared against in vivo 4-dimensional flow MRI (4D Flow). FSI simulation compared well with 4D Flow, confirming direction and magnitude of the flow jet impinging onto the aortic wall as well as location and extension of secondary flows and vortices developing at systole: the systolic flow jet originating from an elliptical 1.6 cm2 orifice reached a peak velocity of 252.2 cm/s, 0.6% lower than 4D Flow, progressively impinging on the ascending aorta convexity. The FSI model predicted a peak flow rate of 22.4 L/min, 6.7% higher than 4D Flow, and provided BAV leaflets mechanical and flow-induced shear stresses, not directly attainable from MRI. At systole, the ventricular side of the non-fused leaflet revealed the highest wall shear stress (WSS) average magnitude, up to 14.6 Pa along the free margin, with WSS progressively decreasing towards the belly. During diastole, the aortic side of the fused leaflet exhibited the highest diastolic maximum principal stress, up to 322 kPa within the attachment region. Systematic comparison with ground-truth non-invasive MRI can improve the computational model ability to reproduce native BAV hemodynamics and biomechanical response more realistically, and shed light on their role in BAV patients' risk for developing complications; this approach may further contribute to the validation of advanced FSI simulations designed to assess BAV biomechanics. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid–Structure Interaction Approach. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Emendi%2C+Monica%22">Emendi, Monica</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sturla%2C+Francesco%22">Sturla, Francesco</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghosh%2C+Ram+P%2E%22">Ghosh, Ram P.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bianchi%2C+Matteo%22">Bianchi, Matteo</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piatti%2C+Filippo%22">Piatti, Filippo</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pluchinotta%2C+Francesca+R%2E%22">Pluchinotta, Francesca R.</searchLink><relatesTo>1,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giese%2C+Daniel%22">Giese, Daniel</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lombardi%2C+Massimo%22">Lombardi, Massimo</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Redaelli%2C+Alberto%22">Redaelli, Alberto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bluestein%2C+Danny%22">Bluestein, Danny</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> danny.bluestein@stonybrtook.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. 2021, Vol. 49 Issue 2, p627-641. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mitral+valve%22">Mitral valve</searchLink><br /><searchLink fieldCode="DE" term="%22Fluid-structure+interaction%22">Fluid-structure interaction</searchLink><br /><searchLink fieldCode="DE" term="%22Aortic+valve%22">Aortic valve</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Jets+%28Fluid+dynamics%29%22">Jets (Fluid dynamics)</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Congenital bicuspid aortic valve (BAV) consists of two fused cusps and represents a major risk factor for calcific valvular stenosis. Herein, a fully coupled fluid–structure interaction (FSI) BAV model was developed from patient-specific magnetic resonance imaging (MRI) and compared against in vivo 4-dimensional flow MRI (4D Flow). FSI simulation compared well with 4D Flow, confirming direction and magnitude of the flow jet impinging onto the aortic wall as well as location and extension of secondary flows and vortices developing at systole: the systolic flow jet originating from an elliptical 1.6 cm2 orifice reached a peak velocity of 252.2 cm/s, 0.6% lower than 4D Flow, progressively impinging on the ascending aorta convexity. The FSI model predicted a peak flow rate of 22.4 L/min, 6.7% higher than 4D Flow, and provided BAV leaflets mechanical and flow-induced shear stresses, not directly attainable from MRI. At systole, the ventricular side of the non-fused leaflet revealed the highest wall shear stress (WSS) average magnitude, up to 14.6 Pa along the free margin, with WSS progressively decreasing towards the belly. During diastole, the aortic side of the fused leaflet exhibited the highest diastolic maximum principal stress, up to 322 kPa within the attachment region. Systematic comparison with ground-truth non-invasive MRI can improve the computational model ability to reproduce native BAV hemodynamics and biomechanical response more realistically, and shed light on their role in BAV patients' risk for developing complications; this approach may further contribute to the validation of advanced FSI simulations designed to assess BAV biomechanics. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-020-02571-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 627 Subjects: – SubjectFull: Mitral valve Type: general – SubjectFull: Fluid-structure interaction Type: general – SubjectFull: Aortic valve Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Hemodynamics Type: general – SubjectFull: Jets (Fluid dynamics) Type: general – SubjectFull: Biomechanics Type: general Titles: – TitleFull: Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid–Structure Interaction Approach. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Emendi, Monica – PersonEntity: Name: NameFull: Sturla, Francesco – PersonEntity: Name: NameFull: Ghosh, Ram P. – PersonEntity: Name: NameFull: Bianchi, Matteo – PersonEntity: Name: NameFull: Piatti, Filippo – PersonEntity: Name: NameFull: Pluchinotta, Francesca R. – PersonEntity: Name: NameFull: Giese, Daniel – PersonEntity: Name: NameFull: Lombardi, Massimo – PersonEntity: Name: NameFull: Redaelli, Alberto – PersonEntity: Name: NameFull: Bluestein, Danny IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 49 – Type: issue Value: 2 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
| ResultId | 1 |
