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Protecting the skin‐implant interface with transcutaneous silver‐coated skin‐and‐bone‐integrated pylon in pig and rabbit dorsum models.

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Title: Protecting the skin‐implant interface with transcutaneous silver‐coated skin‐and‐bone‐integrated pylon in pig and rabbit dorsum models.
Authors: Shevtsov, Maxim1,2,3,4,5 (AUTHOR) shevtsov-max@mail.ru, Gavrilov, Dmitriy6 (AUTHOR), Yudintceva, Natalia2 (AUTHOR), Zemtsova, Elena7 (AUTHOR), Arbenin, Andrei7 (AUTHOR), Smirnov, Vladimir7 (AUTHOR), Voronkina, Irina8 (AUTHOR), Adamova, Polina8 (AUTHOR), Blinova, Miralda2 (AUTHOR), Mikhailova, Nataliya2 (AUTHOR), Galibin, Oleg3 (AUTHOR), Akkaoui, Michael9 (AUTHOR), Pitkin, Mark10,11 (AUTHOR) mpitkin@tuftsmedicalcenter.org
Source: Journal of Biomedical Materials Research, Part B: Applied Biomaterials. Apr2021, Vol. 109 Issue 4, p584-595. 12p.
Subjects: Energy dispersive X-ray spectroscopy, Physical vapor deposition, Soft tissue infections, Intramedullary rods, Plastic surgery, Rabbits
Geographic Terms: New Zealand
Abstract: Implant‐associated soft tissue infections at the skin‐implant interface represent the most frequent complications in reconstructive surgery and lead to implant failures and revisions. Titanium implants with deep porosity, called skin‐and‐bone‐integrated‐pylons (SBIP), allow for skin ingrowth in the morphologically natural direction, thus restoring a reliable dermal barrier and reducing the risk of infection. Silver coating of the SBIP implant surface using physical vapor deposition technique offers the possibility of preventing biofilm formation and exerting a direct antimicrobial effect during the wound healing phase. In vivo studies employing pig and rabbit dorsum models for assessment of skin ingrowth into the pores of the pylon demonstrated the safety of transcutaneous implantation of the SBIP system. No postoperative complications were reported at the end of the follow‐up period of 6 months. Histological analysis proved skin ingrowth in the minipig model without signs of silver toxicity. Analysis of silver release (using energy dispersive X‐ray spectroscopy) in the model of intramedullary‐inserted silver‐coated SBIP in New Zealand rabbits demonstrated trace amounts of silver after 3 months of in‐bone implantation. In conclusion, selected temporary silver coating of the SBIP implant surface is powerful at preventing the periprosthetic infections without imparing skin ingrowth and can be considered for clinical application. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomedical Materials Research, Part B: Applied Biomaterials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
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Header DbId: egs
DbLabel: Engineering Source
An: 148428932
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Protecting the skin‐implant interface with transcutaneous silver‐coated skin‐and‐bone‐integrated pylon in pig and rabbit dorsum models.
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  Data: <searchLink fieldCode="AR" term="%22Shevtsov%2C+Maxim%22">Shevtsov, Maxim</searchLink><relatesTo>1,2,3,4,5</relatesTo> (AUTHOR)<i> shevtsov-max@mail.ru</i><br /><searchLink fieldCode="AR" term="%22Gavrilov%2C+Dmitriy%22">Gavrilov, Dmitriy</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yudintceva%2C+Natalia%22">Yudintceva, Natalia</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zemtsova%2C+Elena%22">Zemtsova, Elena</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arbenin%2C+Andrei%22">Arbenin, Andrei</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smirnov%2C+Vladimir%22">Smirnov, Vladimir</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Voronkina%2C+Irina%22">Voronkina, Irina</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adamova%2C+Polina%22">Adamova, Polina</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blinova%2C+Miralda%22">Blinova, Miralda</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mikhailova%2C+Nataliya%22">Mikhailova, Nataliya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Galibin%2C+Oleg%22">Galibin, Oleg</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akkaoui%2C+Michael%22">Akkaoui, Michael</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pitkin%2C+Mark%22">Pitkin, Mark</searchLink><relatesTo>10,11</relatesTo> (AUTHOR)<i> mpitkin@tuftsmedicalcenter.org</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials%22">Journal of Biomedical Materials Research, Part B: Applied Biomaterials</searchLink>. Apr2021, Vol. 109 Issue 4, p584-595. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Energy+dispersive+X-ray+spectroscopy%22">Energy dispersive X-ray spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+vapor+deposition%22">Physical vapor deposition</searchLink><br /><searchLink fieldCode="DE" term="%22Soft+tissue+infections%22">Soft tissue infections</searchLink><br /><searchLink fieldCode="DE" term="%22Intramedullary+rods%22">Intramedullary rods</searchLink><br /><searchLink fieldCode="DE" term="%22Plastic+surgery%22">Plastic surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Rabbits%22">Rabbits</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22New+Zealand%22">New Zealand</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Implant‐associated soft tissue infections at the skin‐implant interface represent the most frequent complications in reconstructive surgery and lead to implant failures and revisions. Titanium implants with deep porosity, called skin‐and‐bone‐integrated‐pylons (SBIP), allow for skin ingrowth in the morphologically natural direction, thus restoring a reliable dermal barrier and reducing the risk of infection. Silver coating of the SBIP implant surface using physical vapor deposition technique offers the possibility of preventing biofilm formation and exerting a direct antimicrobial effect during the wound healing phase. In vivo studies employing pig and rabbit dorsum models for assessment of skin ingrowth into the pores of the pylon demonstrated the safety of transcutaneous implantation of the SBIP system. No postoperative complications were reported at the end of the follow‐up period of 6 months. Histological analysis proved skin ingrowth in the minipig model without signs of silver toxicity. Analysis of silver release (using energy dispersive X‐ray spectroscopy) in the model of intramedullary‐inserted silver‐coated SBIP in New Zealand rabbits demonstrated trace amounts of silver after 3 months of in‐bone implantation. In conclusion, selected temporary silver coating of the SBIP implant surface is powerful at preventing the periprosthetic infections without imparing skin ingrowth and can be considered for clinical application. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Biomedical Materials Research, Part B: Applied Biomaterials is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/jbm.b.34725
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      – Code: eng
        Text: English
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        PageCount: 12
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      – SubjectFull: Energy dispersive X-ray spectroscopy
        Type: general
      – SubjectFull: Physical vapor deposition
        Type: general
      – SubjectFull: Soft tissue infections
        Type: general
      – SubjectFull: Intramedullary rods
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      – SubjectFull: Plastic surgery
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      – SubjectFull: Rabbits
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      – SubjectFull: New Zealand
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      – TitleFull: Protecting the skin‐implant interface with transcutaneous silver‐coated skin‐and‐bone‐integrated pylon in pig and rabbit dorsum models.
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              Text: Apr2021
              Type: published
              Y: 2021
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