View in EDS

A Mo(VI) based coordination polymer as an antiproliferative agent against cancer cells.

Saved in:
Bibliographic Details
Title: A Mo(VI) based coordination polymer as an antiproliferative agent against cancer cells.
Authors: Joshi, Arti1 (AUTHOR), Gupta, Ruby1 (AUTHOR), Sharma, Deepika1 (AUTHOR), Singh, Monika1 (AUTHOR) monika@inst.ac.in
Source: Dalton Transactions: An International Journal of Inorganic Chemistry. 1/28/2021, Vol. 50 Issue 4, p1253-1260. 8p.
Subjects: Cancer cells, Biological systems, Cell analysis, Multienzyme complexes, Cell cycle, Necrosis
Abstract: Metal ions being an important part of biological systems are of great interest in the designing of new drugs. Molybdenum is an essential trace element for humans, animals, and plants and naturally present in many enzymes hence its complexes can be expected to serve as potential candidates for biomedical applications. A novel molybdenum-based coordination polymer, [Mo2(μ2-O)O4(2-pyc)2(H2O)], is synthesized by a hydrothermal route and structurally characterized by using single crystal X-Ray diffraction. The structure consists of molybdenum octahedra connected by a bridging oxo ligand and 2-pyc forming a one-dimensional coordination polymer. This Mo coordination polymer was found to show a considerable inhibitory effect with IC50 values of 22.63 μmol L−1, 28.19 μmol L−1, and 20.97 μmol L−1, against HepG2 (human liver cancer), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines respectively. This is the first attempt at exploring the molybdenum-based coordination polymer for antitumor applications. The cell cytotoxicity analysis revealed that the anti-tumor potential of the compound is governed by arresting of the A549, HepG2, and MCF-7 cancer cells in the S phase of the cell cycle. UV-Visible absorption spectroscopy further revealed the binding interaction between the Mo coordination polymer and ctDNA and the binding constant was found to be 5.9 × 103 L mol−1, which is in agreement with those of well-known groove binders. This binding interaction in turn induces apoptosis and necrosis pathways leading to the death of the cancer cells. [ABSTRACT FROM AUTHOR]
Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 148453166
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Mo(VI) based coordination polymer as an antiproliferative agent against cancer cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Joshi%2C+Arti%22">Joshi, Arti</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Ruby%22">Gupta, Ruby</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharma%2C+Deepika%22">Sharma, Deepika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Monika%22">Singh, Monika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> monika@inst.ac.in</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Dalton+Transactions%3A+An+International+Journal+of+Inorganic+Chemistry%22">Dalton Transactions: An International Journal of Inorganic Chemistry</searchLink>. 1/28/2021, Vol. 50 Issue 4, p1253-1260. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+systems%22">Biological systems</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+analysis%22">Cell analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Multienzyme+complexes%22">Multienzyme complexes</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+cycle%22">Cell cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Necrosis%22">Necrosis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Metal ions being an important part of biological systems are of great interest in the designing of new drugs. Molybdenum is an essential trace element for humans, animals, and plants and naturally present in many enzymes hence its complexes can be expected to serve as potential candidates for biomedical applications. A novel molybdenum-based coordination polymer, [Mo2(μ2-O)O4(2-pyc)2(H2O)], is synthesized by a hydrothermal route and structurally characterized by using single crystal X-Ray diffraction. The structure consists of molybdenum octahedra connected by a bridging oxo ligand and 2-pyc forming a one-dimensional coordination polymer. This Mo coordination polymer was found to show a considerable inhibitory effect with IC50 values of 22.63 μmol L−1, 28.19 μmol L−1, and 20.97 μmol L−1, against HepG2 (human liver cancer), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines respectively. This is the first attempt at exploring the molybdenum-based coordination polymer for antitumor applications. The cell cytotoxicity analysis revealed that the anti-tumor potential of the compound is governed by arresting of the A549, HepG2, and MCF-7 cancer cells in the S phase of the cell cycle. UV-Visible absorption spectroscopy further revealed the binding interaction between the Mo coordination polymer and ctDNA and the binding constant was found to be 5.9 × 103 L mol−1, which is in agreement with those of well-known groove binders. This binding interaction in turn induces apoptosis and necrosis pathways leading to the death of the cancer cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=148453166
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1039/d0dt03865b
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1253
    Subjects:
      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: Biological systems
        Type: general
      – SubjectFull: Cell analysis
        Type: general
      – SubjectFull: Multienzyme complexes
        Type: general
      – SubjectFull: Cell cycle
        Type: general
      – SubjectFull: Necrosis
        Type: general
    Titles:
      – TitleFull: A Mo(VI) based coordination polymer as an antiproliferative agent against cancer cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Joshi, Arti
      – PersonEntity:
          Name:
            NameFull: Gupta, Ruby
      – PersonEntity:
          Name:
            NameFull: Sharma, Deepika
      – PersonEntity:
          Name:
            NameFull: Singh, Monika
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 28
              M: 01
              Text: 1/28/2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 14779226
          Numbering:
            – Type: volume
              Value: 50
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Dalton Transactions: An International Journal of Inorganic Chemistry
              Type: main
ResultId 1