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Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.

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Title: Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.
Authors: Baghdadi, Neazar E.1,2 (AUTHOR), Burke, Benjamin P.3 (AUTHOR), Alresheedi, Tahani2,3,4 (AUTHOR), Nigam, Shubhanchi2,3 (AUTHOR), Saeed, Abdu5 (AUTHOR), Almutairi, Farooq2,6 (AUTHOR), Domarkas, Juozas2,3 (AUTHOR), Khan, Abid3,7 (AUTHOR), Archibald, Stephen J.2,3 (AUTHOR) s.j.archibald@hull.ac.uk
Source: Dalton Transactions: An International Journal of Inorganic Chemistry. 2/7/2021, Vol. 50 Issue 5, p1599-1603. 5p.
Subjects: CXCR4 receptors, Iron oxide nanoparticles, Binding site assay, Silica, Chemokine receptors
Abstract: The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells. [ABSTRACT FROM AUTHOR]
Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 148593299
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Label: Title
  Group: Ti
  Data: Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Baghdadi%2C+Neazar+E%2E%22">Baghdadi, Neazar E.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burke%2C+Benjamin+P%2E%22">Burke, Benjamin P.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alresheedi%2C+Tahani%22">Alresheedi, Tahani</searchLink><relatesTo>2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nigam%2C+Shubhanchi%22">Nigam, Shubhanchi</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saeed%2C+Abdu%22">Saeed, Abdu</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Almutairi%2C+Farooq%22">Almutairi, Farooq</searchLink><relatesTo>2,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Domarkas%2C+Juozas%22">Domarkas, Juozas</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+Abid%22">Khan, Abid</searchLink><relatesTo>3,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Archibald%2C+Stephen+J%2E%22">Archibald, Stephen J.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> s.j.archibald@hull.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Dalton+Transactions%3A+An+International+Journal+of+Inorganic+Chemistry%22">Dalton Transactions: An International Journal of Inorganic Chemistry</searchLink>. 2/7/2021, Vol. 50 Issue 5, p1599-1603. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22CXCR4+receptors%22">CXCR4 receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Iron+oxide+nanoparticles%22">Iron oxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Binding+site+assay%22">Binding site assay</searchLink><br /><searchLink fieldCode="DE" term="%22Silica%22">Silica</searchLink><br /><searchLink fieldCode="DE" term="%22Chemokine+receptors%22">Chemokine receptors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1039/d0dt02626c
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        Text: English
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        PageCount: 5
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      – SubjectFull: CXCR4 receptors
        Type: general
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        Type: general
      – SubjectFull: Binding site assay
        Type: general
      – SubjectFull: Silica
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      – SubjectFull: Chemokine receptors
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      – TitleFull: Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.
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            – D: 07
              M: 02
              Text: 2/7/2021
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              Y: 2021
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