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A cancer cell-specific benzoxadiazole-based fluorescent probe for hydrogen sulfide detection in mitochondria.

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Title: A cancer cell-specific benzoxadiazole-based fluorescent probe for hydrogen sulfide detection in mitochondria.
Authors: Fortibui, Maxine Mambo1 (AUTHOR), Yoon, Dae Wui2 (AUTHOR), Lim, Ja-Yun3 (AUTHOR), Lee, Sohyun1 (AUTHOR), Choi, Minsun1 (AUTHOR), Heo, June Seok3 (AUTHOR), Kim, Jinkwan2 (AUTHOR) jkkim@jwu.ac.kr, Kim, Jinheung1 (AUTHOR) jinheung@ewha.ac.kr
Source: Dalton Transactions: An International Journal of Inorganic Chemistry. 2/21/2021, Vol. 50 Issue 7, p2545-2554. 10p.
Subjects: Fluorescent probes, Hydrogen sulfide, Mitochondria, Cancer cells, DNA probes, Optical properties, Plant mitochondria
Abstract: The present work describes the design and biological applications of a novel colorimetric and fluorescence turn-on probe for hydrosulfide detection. The probe was designed to introduce hemicyanine as the fluorescent skeleton and 7-nitro-1,2,3-benzoxadiazole as the recognition site. The optical properties and responses of the probe towards HS−, anions and some biothiols indicate an impressively high selectivity of the probe towards HS− such that it can be effectively used as an indicator for monitoring the level of HS− in living cells. In biological experiments using the probe, the H2S levels are found to be higher in cancer cells than in normal cells. In addition, the probe is shown to specifically and rapidly detect endogenous H2S, which is produced primarily in the mitochondria of cancer cells, as demonstrated by a co-localization experiment using specific trackers for the detection of cellular organelles in pharmacological inhibition or stimulation studies, without any significant cytotoxic effects. Thus, the results of the chemical and biological experiments described herein demonstrate the potential of this novel probe to specifically, safely, and rapidly detect H2S to distinguish cancer cells from normal cells by targeting it specifically in mitochondria. [ABSTRACT FROM AUTHOR]
Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 148878311
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: A cancer cell-specific benzoxadiazole-based fluorescent probe for hydrogen sulfide detection in mitochondria.
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  Data: <searchLink fieldCode="AR" term="%22Fortibui%2C+Maxine+Mambo%22">Fortibui, Maxine Mambo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoon%2C+Dae+Wui%22">Yoon, Dae Wui</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lim%2C+Ja-Yun%22">Lim, Ja-Yun</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Sohyun%22">Lee, Sohyun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Minsun%22">Choi, Minsun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heo%2C+June+Seok%22">Heo, June Seok</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Jinkwan%22">Kim, Jinkwan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> jkkim@jwu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Jinheung%22">Kim, Jinheung</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jinheung@ewha.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Dalton+Transactions%3A+An+International+Journal+of+Inorganic+Chemistry%22">Dalton Transactions: An International Journal of Inorganic Chemistry</searchLink>. 2/21/2021, Vol. 50 Issue 7, p2545-2554. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Fluorescent+probes%22">Fluorescent probes</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen+sulfide%22">Hydrogen sulfide</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondria%22">Mitochondria</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+probes%22">DNA probes</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+properties%22">Optical properties</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+mitochondria%22">Plant mitochondria</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The present work describes the design and biological applications of a novel colorimetric and fluorescence turn-on probe for hydrosulfide detection. The probe was designed to introduce hemicyanine as the fluorescent skeleton and 7-nitro-1,2,3-benzoxadiazole as the recognition site. The optical properties and responses of the probe towards HS−, anions and some biothiols indicate an impressively high selectivity of the probe towards HS− such that it can be effectively used as an indicator for monitoring the level of HS− in living cells. In biological experiments using the probe, the H2S levels are found to be higher in cancer cells than in normal cells. In addition, the probe is shown to specifically and rapidly detect endogenous H2S, which is produced primarily in the mitochondria of cancer cells, as demonstrated by a co-localization experiment using specific trackers for the detection of cellular organelles in pharmacological inhibition or stimulation studies, without any significant cytotoxic effects. Thus, the results of the chemical and biological experiments described herein demonstrate the potential of this novel probe to specifically, safely, and rapidly detect H2S to distinguish cancer cells from normal cells by targeting it specifically in mitochondria. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
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        Value: 10.1039/d0dt03653f
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 2545
    Subjects:
      – SubjectFull: Fluorescent probes
        Type: general
      – SubjectFull: Hydrogen sulfide
        Type: general
      – SubjectFull: Mitochondria
        Type: general
      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: DNA probes
        Type: general
      – SubjectFull: Optical properties
        Type: general
      – SubjectFull: Plant mitochondria
        Type: general
    Titles:
      – TitleFull: A cancer cell-specific benzoxadiazole-based fluorescent probe for hydrogen sulfide detection in mitochondria.
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            NameFull: Fortibui, Maxine Mambo
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            NameFull: Lim, Ja-Yun
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            NameFull: Lee, Sohyun
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            – D: 21
              M: 02
              Text: 2/21/2021
              Type: published
              Y: 2021
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              Value: 50
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