Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site.
Saved in:
| Title: | Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site. |
|---|---|
| Authors: | Conti, Simone1, Kaczorowski, Kevin J.2,3, Ge Song4,5,6, Porter, Katelyn4,5,6, Andrabi, Raiees4,5,6, Burton, Dennis R.4,5,6,7, Chakraborty, Arup K.2,3,7,8,9 arupc@mit.edu, Karplus, Martin1,10 marci@tammy.harvard.edu |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 3/2/2021, Vol. 118 Issue 9, p1-12. 12p. |
| Subjects: | HIV antibodies, Binding sites, B cells, Vaccine development, AIDS |
| Abstract: | A vaccine which is effective against the HIV virus is considered to be the best solution to the ongoing global HIV/AIDS epidemic. In the past thirty years, numerous attempts to develop an effective vaccine have been made with little or no success, due, in large part, to the high mutability of the virus. More recent studies showed that a vaccine able to elicit broadly neutralizing antibodies (bnAbs), that is, antibodies that can neutralize a high fraction of global virus variants, has promise to protect against HIV. Such a vaccine has been proposed to involve at least three separate stages: First, activate the appropriate precursor B cells; second, shepherd affinity maturation along pathways toward bnAbs; and, third, polish the Ab response to bind with high affinity to diverse HIV envelopes (Env). This final stage may require immunization with a mixture of Envs. In this paper, we set up a framework based on theory and modeling to design optimal panels of antigens to use in such a mixture. The designed antigens are characterized experimentally and are shown to be stable and to be recognized by known HIV antibodies. [ABSTRACT FROM AUTHOR] |
| Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 149206918 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Conti%2C+Simone%22">Conti, Simone</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kaczorowski%2C+Kevin+J%2E%22">Kaczorowski, Kevin J.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ge+Song%22">Ge Song</searchLink><relatesTo>4,5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Porter%2C+Katelyn%22">Porter, Katelyn</searchLink><relatesTo>4,5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Andrabi%2C+Raiees%22">Andrabi, Raiees</searchLink><relatesTo>4,5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Burton%2C+Dennis+R%2E%22">Burton, Dennis R.</searchLink><relatesTo>4,5,6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Chakraborty%2C+Arup+K%2E%22">Chakraborty, Arup K.</searchLink><relatesTo>2,3,7,8,9</relatesTo><i> arupc@mit.edu</i><br /><searchLink fieldCode="AR" term="%22Karplus%2C+Martin%22">Karplus, Martin</searchLink><relatesTo>1,10</relatesTo><i> marci@tammy.harvard.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 3/2/2021, Vol. 118 Issue 9, p1-12. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22HIV+antibodies%22">HIV antibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Binding+sites%22">Binding sites</searchLink><br /><searchLink fieldCode="DE" term="%22B+cells%22">B cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccine+development%22">Vaccine development</searchLink><br /><searchLink fieldCode="DE" term="%22AIDS%22">AIDS</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: A vaccine which is effective against the HIV virus is considered to be the best solution to the ongoing global HIV/AIDS epidemic. In the past thirty years, numerous attempts to develop an effective vaccine have been made with little or no success, due, in large part, to the high mutability of the virus. More recent studies showed that a vaccine able to elicit broadly neutralizing antibodies (bnAbs), that is, antibodies that can neutralize a high fraction of global virus variants, has promise to protect against HIV. Such a vaccine has been proposed to involve at least three separate stages: First, activate the appropriate precursor B cells; second, shepherd affinity maturation along pathways toward bnAbs; and, third, polish the Ab response to bind with high affinity to diverse HIV envelopes (Env). This final stage may require immunization with a mixture of Envs. In this paper, we set up a framework based on theory and modeling to design optimal panels of antigens to use in such a mixture. The designed antigens are characterized experimentally and are shown to be stable and to be recognized by known HIV antibodies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=149206918 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2018338118 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: HIV antibodies Type: general – SubjectFull: Binding sites Type: general – SubjectFull: B cells Type: general – SubjectFull: Vaccine development Type: general – SubjectFull: AIDS Type: general Titles: – TitleFull: Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Conti, Simone – PersonEntity: Name: NameFull: Kaczorowski, Kevin J. – PersonEntity: Name: NameFull: Ge Song – PersonEntity: Name: NameFull: Porter, Katelyn – PersonEntity: Name: NameFull: Andrabi, Raiees – PersonEntity: Name: NameFull: Burton, Dennis R. – PersonEntity: Name: NameFull: Chakraborty, Arup K. – PersonEntity: Name: NameFull: Karplus, Martin IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 03 Text: 3/2/2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00278424 Numbering: – Type: volume Value: 118 – Type: issue Value: 9 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
| ResultId | 1 |
