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Computational investigation of blood flow and flow-mediated transport in arterial thrombus neighborhood.

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Title: Computational investigation of blood flow and flow-mediated transport in arterial thrombus neighborhood.
Authors: Teeraratkul, Chayut1 (AUTHOR), Irwin, Zachariah1 (AUTHOR), Shadden, Shawn C.2 (AUTHOR), Mukherjee, Debanjan1 (AUTHOR) debanjan@colorado.edu
Source: Biomechanics & Modeling in Mechanobiology. Apr2021, Vol. 20 Issue 2, p701-715. 15p.
Subjects: Thrombosis, Pulsatile flow, Viscous flow, Unsteady flow, Neighborhoods, Blood flow, Advection-diffusion equations, Hemodynamics
Abstract: A pathologically formed blood clot or thrombus is central to major cardiovascular diseases like heart attack and stroke. Detailed quantitative evaluation of flow and flow-mediated transport processes in the thrombus neighborhood within large artery hemodynamics is crucial for understanding disease progression and assessing treatment efficacy. This, however, remains a challenging task owing to the complexity of pulsatile viscous flow interactions with arbitrary shape and heterogeneous microstructure of realistic thrombi. Here, we address this challenge by conducting a systematic parametric simulation-based study on characterizing unsteady hemodynamics and flow-mediated transport in the neighborhood of an arterial thrombus. We use a hybrid particle—continuum-based finite element approach to handle arbitrary thrombus shape and microstructural variations. Results from a cohort of 50 different unsteady flow scenarios are presented, including unsteady vortical structures, pressure gradient across the thrombus boundary, finite time Lyapunov exponents, and dynamic coherent structures that organize advective transport. We clearly illustrate the combined influence of three key parameters—thrombus shape, microstructure, and extent of wall disease—in terms of: (a) determining hemodynamic features in the thrombus neighborhood and (b) governing the balance between advection, permeation, and diffusion to regulate transport processes in the thrombus neighborhood. [ABSTRACT FROM AUTHOR]
Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Computational investigation of blood flow and flow-mediated transport in arterial thrombus neighborhood.
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  Data: <searchLink fieldCode="AR" term="%22Teeraratkul%2C+Chayut%22">Teeraratkul, Chayut</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Irwin%2C+Zachariah%22">Irwin, Zachariah</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shadden%2C+Shawn+C%2E%22">Shadden, Shawn C.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mukherjee%2C+Debanjan%22">Mukherjee, Debanjan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> debanjan@colorado.edu</i>
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  Data: <searchLink fieldCode="DE" term="%22Thrombosis%22">Thrombosis</searchLink><br /><searchLink fieldCode="DE" term="%22Pulsatile+flow%22">Pulsatile flow</searchLink><br /><searchLink fieldCode="DE" term="%22Viscous+flow%22">Viscous flow</searchLink><br /><searchLink fieldCode="DE" term="%22Unsteady+flow%22">Unsteady flow</searchLink><br /><searchLink fieldCode="DE" term="%22Neighborhoods%22">Neighborhoods</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+flow%22">Blood flow</searchLink><br /><searchLink fieldCode="DE" term="%22Advection-diffusion+equations%22">Advection-diffusion equations</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink>
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  Data: A pathologically formed blood clot or thrombus is central to major cardiovascular diseases like heart attack and stroke. Detailed quantitative evaluation of flow and flow-mediated transport processes in the thrombus neighborhood within large artery hemodynamics is crucial for understanding disease progression and assessing treatment efficacy. This, however, remains a challenging task owing to the complexity of pulsatile viscous flow interactions with arbitrary shape and heterogeneous microstructure of realistic thrombi. Here, we address this challenge by conducting a systematic parametric simulation-based study on characterizing unsteady hemodynamics and flow-mediated transport in the neighborhood of an arterial thrombus. We use a hybrid particle—continuum-based finite element approach to handle arbitrary thrombus shape and microstructural variations. Results from a cohort of 50 different unsteady flow scenarios are presented, including unsteady vortical structures, pressure gradient across the thrombus boundary, finite time Lyapunov exponents, and dynamic coherent structures that organize advective transport. We clearly illustrate the combined influence of three key parameters—thrombus shape, microstructure, and extent of wall disease—in terms of: (a) determining hemodynamic features in the thrombus neighborhood and (b) governing the balance between advection, permeation, and diffusion to regulate transport processes in the thrombus neighborhood. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10237-020-01411-7
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        Text: English
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      – SubjectFull: Viscous flow
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      – SubjectFull: Hemodynamics
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              Text: Apr2021
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