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Absent atherosclerotic risk factors are associated with carotid stiffening quantified with ultrafast ultrasound imaging.

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Title: Absent atherosclerotic risk factors are associated with carotid stiffening quantified with ultrafast ultrasound imaging.
Authors: Zhu, Zheng-Qiu1 (AUTHOR), Chen, Ling-Shan2 (AUTHOR), Jiang, Xue-Zhong3 (AUTHOR), Wu, Yi-Yun1 (AUTHOR), Zou, Chong4,5 (AUTHOR), Luan, Yun1 (AUTHOR), Gao, Hui1 (AUTHOR), Dai, Ping1 (AUTHOR), Ma, Xue-Hui1 (AUTHOR), Wu, Lin-Lin1 (AUTHOR), Sun, Hui-Juan1 (AUTHOR), Wang, Yin-Ping1 (AUTHOR), Zou, Fei4 (AUTHOR), Liu, Fu-Ming4 (AUTHOR) doctor.liufuming@outlook.com, Huang, Hui1 (AUTHOR) szcrhh007@vip.163.com
Source: European Radiology. May2021, Vol. 31 Issue 5, p3195-3206. 12p. 1 Color Photograph, 1 Diagram, 2 Charts, 4 Graphs.
Subjects: Ultrasonic imaging, Carotid intima-media thickness, Cardiovascular diseases risk factors, Body mass index, Blood pressure
Abstract: Objectives: To evaluate carotid stiffening in participants without conventional cardiovascular risk factors (CVRFs) by using ultrafast pulse wave velocity (ufPWV). Methods: The present study enrolled 517 participants without conventional CVRFs (CVRF-Free total population). Subjects in this population were defined as current non-smokers with untreated blood pressure < 140/90 mmHg, fasting blood glucose (FBG) < 7.0 mmol/L, total cholesterol (TC) < 6.2 mmol/L, low-density lipoprotein cholesterol < 4.1 mmol/L, and high-density lipoprotein cholesterol ≥ 1.0 mmol/L. Participants in the subgroup with optimal CVRFs (CVRF-Optimal subgroup; n = 188) were defined as having blood pressure < 120/80 mmHg, TC < 5.2 mmol/L, and FBG < 5.6 mmol/L. Clinical interviews, physical examinations, serum draw, carotid intima-media thickness (cIMT), and ufPWV were evaluated. Adjusted odds ratios (ORs) with 95% confidence intervals and ordinal logistic regression models were used. Results: Carotid stiffening was present in 46.2–54.5% of CVRF-Free subjects. Age, male sex, and body mass index (BMI) were independently associated with carotid stiffening in both the CVRF-Free total population and CVRF-Optimal subgroup (OR for age = 1.10–1.11, OR for male sex = 2.65–7.19, OR for BMI = 1.34–1.62; p < 0.05). Carotid stiffening was associated with TC only in the CVRF-Free total population (OR for TC = 1.84; p = 0.034). Conclusions: Many CVRF-Free individuals have carotid stiffening. ufPWV for atherosclerotic stiffening aids the assessment of early atherogenesis and may further clarify the true status of healthy adults without CVRFs. Key Points: • CVRF-Optimal individuals have a lower carotid stiffness than CVRF-Free populations. • ufPWV is a quantitative predictor for the early assessment of AS. • Absent major CVRFs cannot be considered low risk for carotid stiffening and atherosclerosis. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Absent atherosclerotic risk factors are associated with carotid stiffening quantified with ultrafast ultrasound imaging.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhu%2C+Zheng-Qiu%22&quot;&gt;Zhu, Zheng-Qiu&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Ling-Shan%22&quot;&gt;Chen, Ling-Shan&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiang%2C+Xue-Zhong%22&quot;&gt;Jiang, Xue-Zhong&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Yi-Yun%22&quot;&gt;Wu, Yi-Yun&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zou%2C+Chong%22&quot;&gt;Zou, Chong&lt;/searchLink&gt;&lt;relatesTo&gt;4,5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Luan%2C+Yun%22&quot;&gt;Luan, Yun&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gao%2C+Hui%22&quot;&gt;Gao, Hui&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dai%2C+Ping%22&quot;&gt;Dai, Ping&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ma%2C+Xue-Hui%22&quot;&gt;Ma, Xue-Hui&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Lin-Lin%22&quot;&gt;Wu, Lin-Lin&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sun%2C+Hui-Juan%22&quot;&gt;Sun, Hui-Juan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Yin-Ping%22&quot;&gt;Wang, Yin-Ping&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zou%2C+Fei%22&quot;&gt;Zou, Fei&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Fu-Ming%22&quot;&gt;Liu, Fu-Ming&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; doctor.liufuming@outlook.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huang%2C+Hui%22&quot;&gt;Huang, Hui&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; szcrhh007@vip.163.com&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. May2021, Vol. 31 Issue 5, p3195-3206. 12p. 1 Color Photograph, 1 Diagram, 2 Charts, 4 Graphs.
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– Name: Abstract
  Label: Abstract
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  Data: Objectives: To evaluate carotid stiffening in participants without conventional cardiovascular risk factors (CVRFs) by using ultrafast pulse wave velocity (ufPWV). Methods: The present study enrolled 517 participants without conventional CVRFs (CVRF-Free total population). Subjects in this population were defined as current non-smokers with untreated blood pressure &lt; 140/90 mmHg, fasting blood glucose (FBG) &lt; 7.0 mmol/L, total cholesterol (TC) &lt; 6.2 mmol/L, low-density lipoprotein cholesterol &lt; 4.1 mmol/L, and high-density lipoprotein cholesterol ≥ 1.0 mmol/L. Participants in the subgroup with optimal CVRFs (CVRF-Optimal subgroup; n = 188) were defined as having blood pressure &lt; 120/80 mmHg, TC &lt; 5.2 mmol/L, and FBG &lt; 5.6 mmol/L. Clinical interviews, physical examinations, serum draw, carotid intima-media thickness (cIMT), and ufPWV were evaluated. Adjusted odds ratios (ORs) with 95% confidence intervals and ordinal logistic regression models were used. Results: Carotid stiffening was present in 46.2–54.5% of CVRF-Free subjects. Age, male sex, and body mass index (BMI) were independently associated with carotid stiffening in both the CVRF-Free total population and CVRF-Optimal subgroup (OR for age = 1.10–1.11, OR for male sex = 2.65–7.19, OR for BMI = 1.34–1.62; p &lt; 0.05). Carotid stiffening was associated with TC only in the CVRF-Free total population (OR for TC = 1.84; p = 0.034). Conclusions: Many CVRF-Free individuals have carotid stiffening. ufPWV for atherosclerotic stiffening aids the assessment of early atherogenesis and may further clarify the true status of healthy adults without CVRFs. Key Points: • CVRF-Optimal individuals have a lower carotid stiffness than CVRF-Free populations. • ufPWV is a quantitative predictor for the early assessment of AS. • Absent major CVRFs cannot be considered low risk for carotid stiffening and atherosclerosis. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-020-07405-4
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