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The role of chemical synthesis in developing RiPP antibiotics.

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Title: The role of chemical synthesis in developing RiPP antibiotics.
Authors: Rowe, Sam M.1 (AUTHOR), Spring, David R.1 (AUTHOR) spring@ch.cam.ac.uk
Source: Chemical Society Reviews. 4/7/2021, Vol. 50 Issue 7, p4245-4258. 14p.
Subjects: Chemical synthesis, Peptide antibiotics, Antibiotics, Peptide drugs, Anti-infective agents, Drug resistance in microorganisms
Abstract: The growing antimicrobial resistance crisis necessitates the discovery and development of novel classes of antibiotics if a 'postantibiotic era' is to be avoided. Ribosomally synthesised and post-translationally modified peptides, or RiPPs, are becoming increasingly recognised as a potential source of antimicrobial drugs. This is due to a combination of their potent antimicrobial activity and their high stability relative to unmodified linear peptides. However, as peptide drugs, their clinical development is often perturbed by issues such as low solubility and poor bioavailability. Chemical synthesis has the potential to overcome some of these challenges. Furthermore, the structural complexity of RiPPs makes them interesting synthetic targets in their own right, with the total synthesis of some structural classes having only been recently realised. This review focusses on the use of RiPPs as antimicrobial agents and will highlight various strategies that have been employed to chemically synthesise three major classes of RiPPs: lasso peptides, cyclotides, and lanthipeptides. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The role of chemical synthesis in developing RiPP antibiotics.
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  Data: <searchLink fieldCode="AR" term="%22Rowe%2C+Sam+M%2E%22">Rowe, Sam M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spring%2C+David+R%2E%22">Spring, David R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> spring@ch.cam.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Society+Reviews%22">Chemical Society Reviews</searchLink>. 4/7/2021, Vol. 50 Issue 7, p4245-4258. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Chemical+synthesis%22">Chemical synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Peptide+antibiotics%22">Peptide antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Antibiotics%22">Antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Peptide+drugs%22">Peptide drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-infective+agents%22">Anti-infective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+microorganisms%22">Drug resistance in microorganisms</searchLink>
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  Data: The growing antimicrobial resistance crisis necessitates the discovery and development of novel classes of antibiotics if a 'postantibiotic era' is to be avoided. Ribosomally synthesised and post-translationally modified peptides, or RiPPs, are becoming increasingly recognised as a potential source of antimicrobial drugs. This is due to a combination of their potent antimicrobial activity and their high stability relative to unmodified linear peptides. However, as peptide drugs, their clinical development is often perturbed by issues such as low solubility and poor bioavailability. Chemical synthesis has the potential to overcome some of these challenges. Furthermore, the structural complexity of RiPPs makes them interesting synthetic targets in their own right, with the total synthesis of some structural classes having only been recently realised. This review focusses on the use of RiPPs as antimicrobial agents and will highlight various strategies that have been employed to chemically synthesise three major classes of RiPPs: lasso peptides, cyclotides, and lanthipeptides. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1039/d0cs01386b
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 4245
    Subjects:
      – SubjectFull: Chemical synthesis
        Type: general
      – SubjectFull: Peptide antibiotics
        Type: general
      – SubjectFull: Antibiotics
        Type: general
      – SubjectFull: Peptide drugs
        Type: general
      – SubjectFull: Anti-infective agents
        Type: general
      – SubjectFull: Drug resistance in microorganisms
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      – TitleFull: The role of chemical synthesis in developing RiPP antibiotics.
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              Text: 4/7/2021
              Type: published
              Y: 2021
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