Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy.
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| Title: | Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy. |
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| Authors: | Gillmann, Clarissa1,2 (AUTHOR) c.gillmann@dkfz.de, Homolka, Noa1,2,3 (AUTHOR), Johnen, Wibke1,2 (AUTHOR), Runz, Armin1,2 (AUTHOR), Echner, Gernot1,2 (AUTHOR), Pfaffenberger, Asja1,2 (AUTHOR), Mann, Philipp1,2 (AUTHOR), Schneider, Verena4 (AUTHOR), Hoffmann, Aswin L.5,6,7 (AUTHOR), Troost, Esther G. C.5,6,7,8,9 (AUTHOR), Koerber, Stefan A.2,10,11 (AUTHOR), Kotzerke, Jörg6,12 (AUTHOR), Beuthien‐Baumann, Bettina4,10 (AUTHOR) |
| Source: | Medical Physics. Apr2021, Vol. 48 Issue 4, p1624-1632. 9p. |
| Subjects: | Positron emission tomography, Magnetic resonance imaging, Pelvis, Computed tomography, Pelvic bones, Lymphatic metastasis |
| Abstract: | Objective: To develop an anthropomorphic, deformable and multimodal pelvis phantom with positron emission tomography extension for radiotherapy (ADAM PETer). Methods: The design of ADAM PETer was based on our previous pelvis phantom (ADAM) and extended for compatibility with PET and use in 3T magnetic resonance imaging (MRI). The formerly manually manufactured silicon organ surrogates were replaced by three‐dimensional (3D) printed organ shells. Two intraprostatic lesions, four iliac lymph node metastases and two pelvic bone metastases were added to simulate prostate cancer as multifocal and metastatic disease. Radiological properties [computed tomography (CT) and 3T MRI] of cortical bone, bone marrow and adipose tissue were simulated by heavy gypsum, a mixture of Vaseline and K2HPO4 and peanut oil, respectively. For soft tissues, agarose gels with varying concentrations of agarose, gadolinium (Gd) and sodium fluoride (NaF) were developed. The agarose gels were doped with patient‐specific activity concentrations of a Fluorine‐18 labelled compound and then filled into the 3D printed organ shells of prostate lesions, lymph node and bone metastases. The phantom was imaged at a dual energy CT and a 3T PET/MRI scanner. Results: The compositions of the soft tissue surrogates are the following (given as mass fractions of agarose[w%]/NaF[w%]/Gd[w%]): Muscle (4/1/0.027), prostate (1.35/4.2/0.011), prostate lesions (2.25/4.2/0.0085), lymph node and bone metastases (1.4/4.2/0.025). In all imaging modalities, the phantom simulates human contrast. Intraprostatic lesions appear hypointense as compared to the surrounding normal prostate tissue in T2‐weighted MRI. The PET signal of all tumors can be localized as focal spots at their respective site. Activity concentrations of 12.0 kBq/mL (prostate lesion), 12.4 kBq/mL (lymph nodes) and 39.5 kBq/mL (bone metastases) were measured. Conclusion: The ADAM PETer pelvis phantom can be used as multimodal, anthropomorphic model for CT, 3T‐MRI and PET measurements. It will be central to simulate and optimize the technical workflow for the integration of PET/MRI‐based radiation treatment planning of prostate cancer patients. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gillmann%2C+Clarissa%22">Gillmann, Clarissa</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> c.gillmann@dkfz.de</i><br /><searchLink fieldCode="AR" term="%22Homolka%2C+Noa%22">Homolka, Noa</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johnen%2C+Wibke%22">Johnen, Wibke</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Runz%2C+Armin%22">Runz, Armin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Echner%2C+Gernot%22">Echner, Gernot</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pfaffenberger%2C+Asja%22">Pfaffenberger, Asja</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mann%2C+Philipp%22">Mann, Philipp</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schneider%2C+Verena%22">Schneider, Verena</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoffmann%2C+Aswin+L%2E%22">Hoffmann, Aswin L.</searchLink><relatesTo>5,6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Troost%2C+Esther+G%2E+C%2E%22">Troost, Esther G. C.</searchLink><relatesTo>5,6,7,8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koerber%2C+Stefan+A%2E%22">Koerber, Stefan A.</searchLink><relatesTo>2,10,11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kotzerke%2C+Jörg%22">Kotzerke, Jörg</searchLink><relatesTo>6,12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beuthien‐Baumann%2C+Bettina%22">Beuthien‐Baumann, Bettina</searchLink><relatesTo>4,10</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Apr2021, Vol. 48 Issue 4, p1624-1632. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Pelvis%22">Pelvis</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Pelvic+bones%22">Pelvic bones</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphatic+metastasis%22">Lymphatic metastasis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: To develop an anthropomorphic, deformable and multimodal pelvis phantom with positron emission tomography extension for radiotherapy (ADAM PETer). Methods: The design of ADAM PETer was based on our previous pelvis phantom (ADAM) and extended for compatibility with PET and use in 3T magnetic resonance imaging (MRI). The formerly manually manufactured silicon organ surrogates were replaced by three‐dimensional (3D) printed organ shells. Two intraprostatic lesions, four iliac lymph node metastases and two pelvic bone metastases were added to simulate prostate cancer as multifocal and metastatic disease. Radiological properties [computed tomography (CT) and 3T MRI] of cortical bone, bone marrow and adipose tissue were simulated by heavy gypsum, a mixture of Vaseline and K2HPO4 and peanut oil, respectively. For soft tissues, agarose gels with varying concentrations of agarose, gadolinium (Gd) and sodium fluoride (NaF) were developed. The agarose gels were doped with patient‐specific activity concentrations of a Fluorine‐18 labelled compound and then filled into the 3D printed organ shells of prostate lesions, lymph node and bone metastases. The phantom was imaged at a dual energy CT and a 3T PET/MRI scanner. Results: The compositions of the soft tissue surrogates are the following (given as mass fractions of agarose[w%]/NaF[w%]/Gd[w%]): Muscle (4/1/0.027), prostate (1.35/4.2/0.011), prostate lesions (2.25/4.2/0.0085), lymph node and bone metastases (1.4/4.2/0.025). In all imaging modalities, the phantom simulates human contrast. Intraprostatic lesions appear hypointense as compared to the surrounding normal prostate tissue in T2‐weighted MRI. The PET signal of all tumors can be localized as focal spots at their respective site. Activity concentrations of 12.0 kBq/mL (prostate lesion), 12.4 kBq/mL (lymph nodes) and 39.5 kBq/mL (bone metastases) were measured. Conclusion: The ADAM PETer pelvis phantom can be used as multimodal, anthropomorphic model for CT, 3T‐MRI and PET measurements. It will be central to simulate and optimize the technical workflow for the integration of PET/MRI‐based radiation treatment planning of prostate cancer patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mp.14597 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1624 Subjects: – SubjectFull: Positron emission tomography Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Pelvis Type: general – SubjectFull: Computed tomography Type: general – SubjectFull: Pelvic bones Type: general – SubjectFull: Lymphatic metastasis Type: general Titles: – TitleFull: Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gillmann, Clarissa – PersonEntity: Name: NameFull: Homolka, Noa – PersonEntity: Name: NameFull: Johnen, Wibke – PersonEntity: Name: NameFull: Runz, Armin – PersonEntity: Name: NameFull: Echner, Gernot – PersonEntity: Name: NameFull: Pfaffenberger, Asja – PersonEntity: Name: NameFull: Mann, Philipp – PersonEntity: Name: NameFull: Schneider, Verena – PersonEntity: Name: NameFull: Hoffmann, Aswin L. – PersonEntity: Name: NameFull: Troost, Esther G. C. – PersonEntity: Name: NameFull: Koerber, Stefan A. – PersonEntity: Name: NameFull: Kotzerke, Jörg – PersonEntity: Name: NameFull: Beuthien‐Baumann, Bettina IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 48 – Type: issue Value: 4 Titles: – TitleFull: Medical Physics Type: main |
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