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Calibration of T2 oximetry MRI for subjects with sickle cell disease.

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Title: Calibration of T2 oximetry MRI for subjects with sickle cell disease.
Authors: Bush, Adam1,2 (AUTHOR), Vu, Chau1 (AUTHOR), Choi, Soyoung3 (AUTHOR), Borzage, Matthew4 (AUTHOR), Miao, Xin1 (AUTHOR), Li, Wenbo5,6 (AUTHOR), Qin, Qin5,6 (AUTHOR), Nederveen, Aart J.7 (AUTHOR), Coates, Thomas D.8,9 (AUTHOR), Wood, John C.1,10 (AUTHOR) jwood@chla.usc.edu
Source: Magnetic Resonance in Medicine. Aug2021, Vol. 86 Issue 2, p1019-1028. 10p.
Subjects: Sickle cell anemia, Erythrocytes, Oximetry, Calibration, Cell morphology
Abstract: Purpose: Cerebral T2 oximetry is a non‐invasive imaging method to measure blood T2 and cerebral venous oxygenation. Measured T2 values are converted to oximetry estimates using carefully validated and potentially disease‐specific calibrations. In sickle cell disease, red blood cells have abnormal cell shape and membrane properties that alter T2 oximetry calibration relationships in clinically meaningful ways. Previous in vitro works by two independent groups established potentially competing calibration models. Methods: This study analyzed pooled datasets from these two studies to establish a unified and more robust sickle‐specific calibration to serve as a reference standard in the field. Results: Even though the combined calibration did not demonstrate statistical superiority compared to previous models, the calibration was unbiased compared to blood‐gas co‐oximetry and yielded limits of agreement of (−10.1%, 11.6%) in non‐transfused subjects with sickle cell disease. In transfused patients, this study proposed a simple correction method based on individual hemoglobin S percentage that demonstrated reduced bias in saturation measurement compared to previous uncorrected sickle calibrations. Conclusion: The combined calibration is based on a larger range of hematocrit, providing greater confidence in the hematocrit‐dependent model parameters, and yielded unbiased estimates to blood‐gas co‐oximetry measurements from both sites. Additionally, this work also demonstrated the need to correct for transfusion in T2 oximetry measurements for hyper‐transfused sickle cell disease patients and proposes a correction method based on patient‐specific hemoglobin S concentration. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Calibration of T<subscript>2</subscript> oximetry MRI for subjects with sickle cell disease.
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  Data: <searchLink fieldCode="AR" term="%22Bush%2C+Adam%22">Bush, Adam</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vu%2C+Chau%22">Vu, Chau</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Soyoung%22">Choi, Soyoung</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Borzage%2C+Matthew%22">Borzage, Matthew</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miao%2C+Xin%22">Miao, Xin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Wenbo%22">Li, Wenbo</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Qin%22">Qin, Qin</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nederveen%2C+Aart+J%2E%22">Nederveen, Aart J.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coates%2C+Thomas+D%2E%22">Coates, Thomas D.</searchLink><relatesTo>8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wood%2C+John+C%2E%22">Wood, John C.</searchLink><relatesTo>1,10</relatesTo> (AUTHOR)<i> jwood@chla.usc.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Aug2021, Vol. 86 Issue 2, p1019-1028. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Sickle+cell+anemia%22">Sickle cell anemia</searchLink><br /><searchLink fieldCode="DE" term="%22Erythrocytes%22">Erythrocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Oximetry%22">Oximetry</searchLink><br /><searchLink fieldCode="DE" term="%22Calibration%22">Calibration</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+morphology%22">Cell morphology</searchLink>
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  Data: Purpose: Cerebral T2 oximetry is a non‐invasive imaging method to measure blood T2 and cerebral venous oxygenation. Measured T2 values are converted to oximetry estimates using carefully validated and potentially disease‐specific calibrations. In sickle cell disease, red blood cells have abnormal cell shape and membrane properties that alter T2 oximetry calibration relationships in clinically meaningful ways. Previous in vitro works by two independent groups established potentially competing calibration models. Methods: This study analyzed pooled datasets from these two studies to establish a unified and more robust sickle‐specific calibration to serve as a reference standard in the field. Results: Even though the combined calibration did not demonstrate statistical superiority compared to previous models, the calibration was unbiased compared to blood‐gas co‐oximetry and yielded limits of agreement of (−10.1%, 11.6%) in non‐transfused subjects with sickle cell disease. In transfused patients, this study proposed a simple correction method based on individual hemoglobin S percentage that demonstrated reduced bias in saturation measurement compared to previous uncorrected sickle calibrations. Conclusion: The combined calibration is based on a larger range of hematocrit, providing greater confidence in the hematocrit‐dependent model parameters, and yielded unbiased estimates to blood‐gas co‐oximetry measurements from both sites. Additionally, this work also demonstrated the need to correct for transfusion in T2 oximetry measurements for hyper‐transfused sickle cell disease patients and proposes a correction method based on patient‐specific hemoglobin S concentration. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.28757
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        Text: English
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        PageCount: 10
        StartPage: 1019
    Subjects:
      – SubjectFull: Sickle cell anemia
        Type: general
      – SubjectFull: Erythrocytes
        Type: general
      – SubjectFull: Oximetry
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      – SubjectFull: Calibration
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      – SubjectFull: Cell morphology
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      – TitleFull: Calibration of T2 oximetry MRI for subjects with sickle cell disease.
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              Text: Aug2021
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