View in EDS

Degradation of lipid based drug delivery formulations during nebulization.

Saved in:
Bibliographic Details
Title: Degradation of lipid based drug delivery formulations during nebulization.
Authors: Klein, David M.1 (AUTHOR), Poortinga, Albert2 (AUTHOR), Verhoeven, Frank M.1 (AUTHOR), Bonn, Daniel2 (AUTHOR), Bonnet, Sylvestre1 (AUTHOR), van Rijn, Cees J.M.1,2 (AUTHOR) c.j.m.vanrijn@uva.nl
Source: Chemical Physics. Jul2021, Vol. 547, pN.PAG-N.PAG. 1p.
Subjects: Lipids, Nebulizers & vaporizers, Drugs, Lungs, Nanoparticles
Abstract: Encapsulating pharmaceuticals in protective lipid based nanoparticles, and nebulizing them towards the target area in the body offers a range of clinical advantages. However, the process of nebulization might possibly damage sensitive nanoparticle structures, such as liposomes, resulting in loss of active pharmaceutical ingredients. We compare this loss for two types of lung inhalation devices: high-frequency piezo-actuated vibrating mesh nebulizers and non-actuated continuous jet nebulizers. We find that vibrating mesh nebulizers cause model liposomes to release more than ten times as much encapsulated material as the continuous jet nebulizers because the energies involved in nebulization are much larger. This result highlights the importance of applying a mild nebulization technology when administering shear-sensitive drug formulations such as lipid nanoparticle based drugs to the lungs. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 150317267
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Degradation of lipid based drug delivery formulations during nebulization.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Klein%2C+David+M%2E%22">Klein, David M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poortinga%2C+Albert%22">Poortinga, Albert</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verhoeven%2C+Frank+M%2E%22">Verhoeven, Frank M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bonn%2C+Daniel%22">Bonn, Daniel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bonnet%2C+Sylvestre%22">Bonnet, Sylvestre</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Rijn%2C+Cees+J%2EM%2E%22">van Rijn, Cees J.M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> c.j.m.vanrijn@uva.nl</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Chemical+Physics%22">Chemical Physics</searchLink>. Jul2021, Vol. 547, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Lipids%22">Lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Nebulizers+%26+vaporizers%22">Nebulizers & vaporizers</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Encapsulating pharmaceuticals in protective lipid based nanoparticles, and nebulizing them towards the target area in the body offers a range of clinical advantages. However, the process of nebulization might possibly damage sensitive nanoparticle structures, such as liposomes, resulting in loss of active pharmaceutical ingredients. We compare this loss for two types of lung inhalation devices: high-frequency piezo-actuated vibrating mesh nebulizers and non-actuated continuous jet nebulizers. We find that vibrating mesh nebulizers cause model liposomes to release more than ten times as much encapsulated material as the continuous jet nebulizers because the energies involved in nebulization are much larger. This result highlights the importance of applying a mild nebulization technology when administering shear-sensitive drug formulations such as lipid nanoparticle based drugs to the lungs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chemical Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=150317267
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.chemphys.2021.111192
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Lipids
        Type: general
      – SubjectFull: Nebulizers & vaporizers
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Lungs
        Type: general
      – SubjectFull: Nanoparticles
        Type: general
    Titles:
      – TitleFull: Degradation of lipid based drug delivery formulations during nebulization.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Klein, David M.
      – PersonEntity:
          Name:
            NameFull: Poortinga, Albert
      – PersonEntity:
          Name:
            NameFull: Verhoeven, Frank M.
      – PersonEntity:
          Name:
            NameFull: Bonn, Daniel
      – PersonEntity:
          Name:
            NameFull: Bonnet, Sylvestre
      – PersonEntity:
          Name:
            NameFull: van Rijn, Cees J.M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 03010104
          Numbering:
            – Type: volume
              Value: 547
          Titles:
            – TitleFull: Chemical Physics
              Type: main
ResultId 1