SiO2-KHSO4 catalyst based rapid synthesis of structurally modified bis(3-indolyl)methanes via N-substituted indole.
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| Title: | SiO2-KHSO4 catalyst based rapid synthesis of structurally modified bis(3-indolyl)methanes via N-substituted indole. |
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| Authors: | Sadiq, Zubi1 (AUTHOR), Ghani, Ambreen2 (AUTHOR), Shujaat, Shahida1 (AUTHOR), Hussain, Erum Akbar1 (AUTHOR) erum.hussain@gmail.com, Alissa, Siham A.3 (AUTHOR), Iqbal, Munawar1,4 (AUTHOR) bosalvee@yahoo.com |
| Source: | Inorganic Chemistry Communications. Jul2021, Vol. 129, pN.PAG-N.PAG. 1p. |
| Subjects: | Base catalysts, Catalyst supports, Methane, Sulfuric acid, Aromatic aldehydes, Indole |
| Abstract: | [Display omitted] • A rapid synthesis of structurally modified bis(3-indolyl)methanes Via N -substituted indole was reported. • SiO 2 -KHSO 4 catalyst used as a solid support catalyst. • Up to 89% yield was achieved within 1 h of reaction time. • For rapid and high yield of bis(3-indolyl)methanes, the use of SiO 2 -KHSO 4 (5%) is suggested. In the present study, s tructurally diverse improvement was made towards bis(indolyl)methanes 5(a-e) and 5′(a-e) along with 6(a-e) and 6′(a-e) by multicomponent approach. Mono and di-N- substituted BIMs were formed by 2(a-e) and 2′(a-e), 3(a-e) and 3′(a-e). Silica-potassium hydrogen sulfate (SiO 2 -KHSO 4) benign and efficient catalyst is used for the synthesis of new compounds where pre-modified indole unit was alkylated by substituted aromatic aldehydes. The yield was significantly affected in the presence of SiO 2 -KHSO 4 and maximum yield (89% in 1 h reaction) of BIMs was achieved using SiO 2 -KHSO 4 (mol 5 %). The SiO 2 -KHSO 4 also considerably reduced the reaction time for the synthesis of BIMs. This protocol was found to be beneficial with respect to catalyst, short reaction time, simple work-up and high yield. The compounds thus prepared are studied through FTIR, 1H NMR and MS spectral data. [ABSTRACT FROM AUTHOR] |
| Copyright of Inorganic Chemistry Communications is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 150695782 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: SiO2-KHSO4 catalyst based rapid synthesis of structurally modified bis(3-indolyl)methanes via N-substituted indole. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sadiq%2C+Zubi%22">Sadiq, Zubi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghani%2C+Ambreen%22">Ghani, Ambreen</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shujaat%2C+Shahida%22">Shujaat, Shahida</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hussain%2C+Erum+Akbar%22">Hussain, Erum Akbar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> erum.hussain@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Alissa%2C+Siham+A%2E%22">Alissa, Siham A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iqbal%2C+Munawar%22">Iqbal, Munawar</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> bosalvee@yahoo.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Inorganic+Chemistry+Communications%22">Inorganic Chemistry Communications</searchLink>. Jul2021, Vol. 129, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Base+catalysts%22">Base catalysts</searchLink><br /><searchLink fieldCode="DE" term="%22Catalyst+supports%22">Catalyst supports</searchLink><br /><searchLink fieldCode="DE" term="%22Methane%22">Methane</searchLink><br /><searchLink fieldCode="DE" term="%22Sulfuric+acid%22">Sulfuric acid</searchLink><br /><searchLink fieldCode="DE" term="%22Aromatic+aldehydes%22">Aromatic aldehydes</searchLink><br /><searchLink fieldCode="DE" term="%22Indole%22">Indole</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: [Display omitted] • A rapid synthesis of structurally modified bis(3-indolyl)methanes Via N -substituted indole was reported. • SiO 2 -KHSO 4 catalyst used as a solid support catalyst. • Up to 89% yield was achieved within 1 h of reaction time. • For rapid and high yield of bis(3-indolyl)methanes, the use of SiO 2 -KHSO 4 (5%) is suggested. In the present study, s tructurally diverse improvement was made towards bis(indolyl)methanes 5(a-e) and 5′(a-e) along with 6(a-e) and 6′(a-e) by multicomponent approach. Mono and di-N- substituted BIMs were formed by 2(a-e) and 2′(a-e), 3(a-e) and 3′(a-e). Silica-potassium hydrogen sulfate (SiO 2 -KHSO 4) benign and efficient catalyst is used for the synthesis of new compounds where pre-modified indole unit was alkylated by substituted aromatic aldehydes. The yield was significantly affected in the presence of SiO 2 -KHSO 4 and maximum yield (89% in 1 h reaction) of BIMs was achieved using SiO 2 -KHSO 4 (mol 5 %). The SiO 2 -KHSO 4 also considerably reduced the reaction time for the synthesis of BIMs. This protocol was found to be beneficial with respect to catalyst, short reaction time, simple work-up and high yield. The compounds thus prepared are studied through FTIR, 1H NMR and MS spectral data. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Inorganic Chemistry Communications is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.inoche.2021.108620 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Base catalysts Type: general – SubjectFull: Catalyst supports Type: general – SubjectFull: Methane Type: general – SubjectFull: Sulfuric acid Type: general – SubjectFull: Aromatic aldehydes Type: general – SubjectFull: Indole Type: general Titles: – TitleFull: SiO2-KHSO4 catalyst based rapid synthesis of structurally modified bis(3-indolyl)methanes via N-substituted indole. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sadiq, Zubi – PersonEntity: Name: NameFull: Ghani, Ambreen – PersonEntity: Name: NameFull: Shujaat, Shahida – PersonEntity: Name: NameFull: Hussain, Erum Akbar – PersonEntity: Name: NameFull: Alissa, Siham A. – PersonEntity: Name: NameFull: Iqbal, Munawar IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 13877003 Numbering: – Type: volume Value: 129 Titles: – TitleFull: Inorganic Chemistry Communications Type: main |
| ResultId | 1 |
