Normal chest CT in 1091 symptomatic patients with confirmed Covid-19: frequency, characteristics and outcome.
Saved in:
| Title: | Normal chest CT in 1091 symptomatic patients with confirmed Covid-19: frequency, characteristics and outcome. |
|---|---|
| Authors: | Leonard-Lorant, Ian1 (AUTHOR), Severac, François2 (AUTHOR), Bilbault, Pascal3 (AUTHOR), Muller, Joris4 (AUTHOR), Leyendecker, Pierre1 (AUTHOR), Roy, Catherine1 (AUTHOR), Ohana, Mickaël1 (AUTHOR) mickael.ohana@gmail.com |
| Source: | European Radiology. Jul2021, Vol. 31 Issue 7, p5172-5177. 6p. 1 Diagram, 1 Chart. |
| Subjects: | Computed tomography, COVID-19, COVID-19 pandemic, Multidetector computed tomography, Reverse transcriptase polymerase chain reaction |
| Abstract: | Objective: Frequency of normal chest CT in symptomatic COVID-19 patients as well as the outcome of these patients remains unknown. The objectives of this work were to assess the incidence of initially normal chest CT in a cohort of consecutive confirmed COVID-19 patients with respiratory symptoms and to compare their clinical characteristics and their outcome to matched patients with typical COVID-19 lesions at initial CT. Methods: From March 6th to April 22nd, all consecutive adult patients referred to the COVID-19 clinic of our Emergency Department were retrospectively analyzed. Each patient with a positive SARS-CoV-2 RT-PCR and a normal initial chest CT after second reading was 1:1 matched based on sex, age and date of CT acquisition to a patient with positive RT-PCR and initial chest CT with typical COVID-19 lesions. Clinical data, laboratory results and outcomes (major being mechanical ventilation and/or death) were compared between both groups, using Wilcoxon signed-rank test, McNemar's chi-squared test and/or exact McNemar's test where appropriate. Results: Fifty-seven chest CT out of 1091 (5.2%, 95% CI 4.0–6.7) in symptomatic patients with positive RT-PCR were normal, with a median onset of symptoms of 4.5 days (IQR [1.25–10.25]). After a median follow-up of 43 days, death and/or mechanical ventilation occurred in 3 patients (5.3%) in the study group, versus 11 (19.3%) in the control group (p = 0.011). Conclusions: Normal initial chest CT occurred in 5.2% of symptomatic confirmed COVID-19 cases in our cohort. While better than those with abnormal chest CT, outcome was not entirely benign with 5.3% death and/or mechanical ventilation. Key Points: • In a cohort of 1091 symptomatic COVID-19 patients, initial chest CT was normal in 5.2% of cases. • Normal chest CT in confirmed COVID-19 is frequent even when onset of symptoms is greater than 3 days. • The outcome of COVID-19 patients with initial normal chest CT, while better than those with abnormal CT, was not entirely benign with 5.3% death and/or mechanical ventilation. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 150974505 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Normal chest CT in 1091 symptomatic patients with confirmed Covid-19: frequency, characteristics and outcome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Leonard-Lorant%2C+Ian%22">Leonard-Lorant, Ian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Severac%2C+François%22">Severac, François</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bilbault%2C+Pascal%22">Bilbault, Pascal</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muller%2C+Joris%22">Muller, Joris</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leyendecker%2C+Pierre%22">Leyendecker, Pierre</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roy%2C+Catherine%22">Roy, Catherine</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ohana%2C+Mickaël%22">Ohana, Mickaël</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mickael.ohana@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jul2021, Vol. 31 Issue 7, p5172-5177. 6p. 1 Diagram, 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+pandemic%22">COVID-19 pandemic</searchLink><br /><searchLink fieldCode="DE" term="%22Multidetector+computed+tomography%22">Multidetector computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Reverse+transcriptase+polymerase+chain+reaction%22">Reverse transcriptase polymerase chain reaction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: Frequency of normal chest CT in symptomatic COVID-19 patients as well as the outcome of these patients remains unknown. The objectives of this work were to assess the incidence of initially normal chest CT in a cohort of consecutive confirmed COVID-19 patients with respiratory symptoms and to compare their clinical characteristics and their outcome to matched patients with typical COVID-19 lesions at initial CT. Methods: From March 6th to April 22nd, all consecutive adult patients referred to the COVID-19 clinic of our Emergency Department were retrospectively analyzed. Each patient with a positive SARS-CoV-2 RT-PCR and a normal initial chest CT after second reading was 1:1 matched based on sex, age and date of CT acquisition to a patient with positive RT-PCR and initial chest CT with typical COVID-19 lesions. Clinical data, laboratory results and outcomes (major being mechanical ventilation and/or death) were compared between both groups, using Wilcoxon signed-rank test, McNemar's chi-squared test and/or exact McNemar's test where appropriate. Results: Fifty-seven chest CT out of 1091 (5.2%, 95% CI 4.0–6.7) in symptomatic patients with positive RT-PCR were normal, with a median onset of symptoms of 4.5 days (IQR [1.25–10.25]). After a median follow-up of 43 days, death and/or mechanical ventilation occurred in 3 patients (5.3%) in the study group, versus 11 (19.3%) in the control group (p = 0.011). Conclusions: Normal initial chest CT occurred in 5.2% of symptomatic confirmed COVID-19 cases in our cohort. While better than those with abnormal chest CT, outcome was not entirely benign with 5.3% death and/or mechanical ventilation. Key Points: • In a cohort of 1091 symptomatic COVID-19 patients, initial chest CT was normal in 5.2% of cases. • Normal chest CT in confirmed COVID-19 is frequent even when onset of symptoms is greater than 3 days. • The outcome of COVID-19 patients with initial normal chest CT, while better than those with abnormal CT, was not entirely benign with 5.3% death and/or mechanical ventilation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=150974505 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-020-07593-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 5172 Subjects: – SubjectFull: Computed tomography Type: general – SubjectFull: COVID-19 Type: general – SubjectFull: COVID-19 pandemic Type: general – SubjectFull: Multidetector computed tomography Type: general – SubjectFull: Reverse transcriptase polymerase chain reaction Type: general Titles: – TitleFull: Normal chest CT in 1091 symptomatic patients with confirmed Covid-19: frequency, characteristics and outcome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Leonard-Lorant, Ian – PersonEntity: Name: NameFull: Severac, François – PersonEntity: Name: NameFull: Bilbault, Pascal – PersonEntity: Name: NameFull: Muller, Joris – PersonEntity: Name: NameFull: Leyendecker, Pierre – PersonEntity: Name: NameFull: Roy, Catherine – PersonEntity: Name: NameFull: Ohana, Mickaël IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 31 – Type: issue Value: 7 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
