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On the role of vesicle transport in neurite growth: Modeling and experiments.

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Title: On the role of vesicle transport in neurite growth: Modeling and experiments.
Authors: Humpert, Ina1 (AUTHOR) ina.humpert@uni-muenster.de, Di Meo, Danila2 (AUTHOR) d_dime01@uni-muenster.de, Püschel, Andreas W.2 (AUTHOR) apuschel@uni-muenster.de, Pietschmann, Jan-Frederik3 (AUTHOR) jfpietschmann@math.tu-chemnitz.de
Source: Mathematical Biosciences. Aug2021, Vol. 338, pN.PAG-N.PAG. 1p.
Subjects: Phenomenological biology, Neuron development, Transport theory, Models & modelmaking, Neurons
Abstract: The processes that determine the establishment of the complex morphology of neurons during development are still poorly understood. Here, we focus on the question how a difference in the length of neurites affects vesicle transport. We performed live imaging experiments and present a lattice-based model to gain a deeper theoretical understanding of intracellular transport in neurons. After a motivation and appropriate scaling of the model we present numerical simulations showing that initial differences in neurite length result in phenomena of biological relevance, i.e. a positive feedback that enhances transport into the longer neurite and oscillation of vesicles concentrations that can be interpreted as cycles of extension and retraction observed in experiments. Thus, our model is a first step towards a better understanding of the interplay between the transport of vesicles and the spatial organization of cells. • Discrete model for vesicle transport with two species and size exclusion. • Experiments and theory suggest that transport increases in neurites with length advantage. • Length differences result in oscillations of vesicle concentration as observed in experiments. • Vesicle transport is linked to changes in neurite length. [ABSTRACT FROM AUTHOR]
Copyright of Mathematical Biosciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 151216862
AccessLevel: 6
PubType: Periodical
PubTypeId: serialPeriodical
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  Data: On the role of vesicle transport in neurite growth: Modeling and experiments.
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  Data: <searchLink fieldCode="AR" term="%22Humpert%2C+Ina%22">Humpert, Ina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ina.humpert@uni-muenster.de</i><br /><searchLink fieldCode="AR" term="%22Di+Meo%2C+Danila%22">Di Meo, Danila</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> d_dime01@uni-muenster.de</i><br /><searchLink fieldCode="AR" term="%22Püschel%2C+Andreas+W%2E%22">Püschel, Andreas W.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> apuschel@uni-muenster.de</i><br /><searchLink fieldCode="AR" term="%22Pietschmann%2C+Jan-Frederik%22">Pietschmann, Jan-Frederik</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> jfpietschmann@math.tu-chemnitz.de</i>
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  Data: <searchLink fieldCode="JN" term="%22Mathematical+Biosciences%22">Mathematical Biosciences</searchLink>. Aug2021, Vol. 338, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Phenomenological+biology%22">Phenomenological biology</searchLink><br /><searchLink fieldCode="DE" term="%22Neuron+development%22">Neuron development</searchLink><br /><searchLink fieldCode="DE" term="%22Transport+theory%22">Transport theory</searchLink><br /><searchLink fieldCode="DE" term="%22Models+%26+modelmaking%22">Models & modelmaking</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink>
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  Data: The processes that determine the establishment of the complex morphology of neurons during development are still poorly understood. Here, we focus on the question how a difference in the length of neurites affects vesicle transport. We performed live imaging experiments and present a lattice-based model to gain a deeper theoretical understanding of intracellular transport in neurons. After a motivation and appropriate scaling of the model we present numerical simulations showing that initial differences in neurite length result in phenomena of biological relevance, i.e. a positive feedback that enhances transport into the longer neurite and oscillation of vesicles concentrations that can be interpreted as cycles of extension and retraction observed in experiments. Thus, our model is a first step towards a better understanding of the interplay between the transport of vesicles and the spatial organization of cells. • Discrete model for vesicle transport with two species and size exclusion. • Experiments and theory suggest that transport increases in neurites with length advantage. • Length differences result in oscillations of vesicle concentration as observed in experiments. • Vesicle transport is linked to changes in neurite length. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Mathematical Biosciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.mbs.2021.108632
    Languages:
      – Code: eng
        Text: English
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        PageCount: 1
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    Subjects:
      – SubjectFull: Phenomenological biology
        Type: general
      – SubjectFull: Neuron development
        Type: general
      – SubjectFull: Transport theory
        Type: general
      – SubjectFull: Models & modelmaking
        Type: general
      – SubjectFull: Neurons
        Type: general
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      – TitleFull: On the role of vesicle transport in neurite growth: Modeling and experiments.
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            NameFull: Humpert, Ina
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            NameFull: Di Meo, Danila
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            NameFull: Püschel, Andreas W.
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            NameFull: Pietschmann, Jan-Frederik
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          Dates:
            – D: 01
              M: 08
              Text: Aug2021
              Type: published
              Y: 2021
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              Value: 338
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            – TitleFull: Mathematical Biosciences
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