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Multi-patient study for coronary vulnerable plaque model comparisons: 2D/3D and fluid–structure interaction simulations.

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Title: Multi-patient study for coronary vulnerable plaque model comparisons: 2D/3D and fluid–structure interaction simulations.
Authors: Wang, Qingyu1 (AUTHOR), Tang, Dalin1,2 (AUTHOR) dtang@wpi.edu, Wang, Liang1 (AUTHOR), Meahara, Akiko3 (AUTHOR), Molony, David4 (AUTHOR), Samady, Habib4 (AUTHOR), Zheng, Jie5 (AUTHOR), Mintz, Gary S.3 (AUTHOR), Stone, Gregg W.3,6 (AUTHOR), Giddens, Don P.4,7 (AUTHOR)
Source: Biomechanics & Modeling in Mechanobiology. Aug2021, Vol. 20 Issue 4, p1383-1397. 15p.
Subjects: Fluid-structure interaction, Intravascular ultrasonography, Shear flow, Atherosclerotic plaque, Kounis syndrome, Fluids
Abstract: Several image-based computational models have been used to perform mechanical analysis for atherosclerotic plaque progression and vulnerability investigations. However, differences of computational predictions from those models have not been quantified at multi-patient level. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from seven patients. Seven 2D/3D models with/without circumferential shrink, cyclic bending and fluid–structure interactions (FSI) were constructed for the seven patients to perform model comparisons and quantify impact of 2D simplification, circumferential shrink, FSI and cyclic bending plaque wall stress/strain (PWS/PWSn) and flow shear stress (FSS) calculations. PWS/PWSn and FSS averages from seven patients (388 slices for 2D and 3D thin-layer models) were used for comparison. Compared to 2D models with shrink process, 2D models without shrink process overestimated PWS by 17.26%. PWS change at location with greatest curvature change from 3D FSI models with/without cyclic bending varied from 15.07% to 49.52% for the seven patients (average = 30.13%). Mean Max-FSS, Min-FSS and Ave-FSS from the flow-only models under maximum pressure condition were 4.02%, 11.29% and 5.45% higher than those from full FSI models with cycle bending, respectively. Mean PWS and PWSn differences between FSI and structure-only models were only 4.38% and 1.78%. Model differences had noticeable patient variations. FSI and flow-only model differences were greater for minimum FSS predictions, notable since low FSS is known to be related to plaque progression. Structure-only models could provide PWS/PWSn calculations as good approximations to FSI models for simplicity and time savings in calculation. [ABSTRACT FROM AUTHOR]
Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Multi-patient study for coronary vulnerable plaque model comparisons: 2D/3D and fluid–structure interaction simulations.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Qingyu%22">Wang, Qingyu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Dalin%22">Tang, Dalin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> dtang@wpi.edu</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Liang%22">Wang, Liang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meahara%2C+Akiko%22">Meahara, Akiko</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Molony%2C+David%22">Molony, David</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Samady%2C+Habib%22">Samady, Habib</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Jie%22">Zheng, Jie</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mintz%2C+Gary+S%2E%22">Mintz, Gary S.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stone%2C+Gregg+W%2E%22">Stone, Gregg W.</searchLink><relatesTo>3,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giddens%2C+Don+P%2E%22">Giddens, Don P.</searchLink><relatesTo>4,7</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Aug2021, Vol. 20 Issue 4, p1383-1397. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Fluid-structure+interaction%22">Fluid-structure interaction</searchLink><br /><searchLink fieldCode="DE" term="%22Intravascular+ultrasonography%22">Intravascular ultrasonography</searchLink><br /><searchLink fieldCode="DE" term="%22Shear+flow%22">Shear flow</searchLink><br /><searchLink fieldCode="DE" term="%22Atherosclerotic+plaque%22">Atherosclerotic plaque</searchLink><br /><searchLink fieldCode="DE" term="%22Kounis+syndrome%22">Kounis syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Fluids%22">Fluids</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Several image-based computational models have been used to perform mechanical analysis for atherosclerotic plaque progression and vulnerability investigations. However, differences of computational predictions from those models have not been quantified at multi-patient level. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from seven patients. Seven 2D/3D models with/without circumferential shrink, cyclic bending and fluid–structure interactions (FSI) were constructed for the seven patients to perform model comparisons and quantify impact of 2D simplification, circumferential shrink, FSI and cyclic bending plaque wall stress/strain (PWS/PWSn) and flow shear stress (FSS) calculations. PWS/PWSn and FSS averages from seven patients (388 slices for 2D and 3D thin-layer models) were used for comparison. Compared to 2D models with shrink process, 2D models without shrink process overestimated PWS by 17.26%. PWS change at location with greatest curvature change from 3D FSI models with/without cyclic bending varied from 15.07% to 49.52% for the seven patients (average = 30.13%). Mean Max-FSS, Min-FSS and Ave-FSS from the flow-only models under maximum pressure condition were 4.02%, 11.29% and 5.45% higher than those from full FSI models with cycle bending, respectively. Mean PWS and PWSn differences between FSI and structure-only models were only 4.38% and 1.78%. Model differences had noticeable patient variations. FSI and flow-only model differences were greater for minimum FSS predictions, notable since low FSS is known to be related to plaque progression. Structure-only models could provide PWS/PWSn calculations as good approximations to FSI models for simplicity and time savings in calculation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10237-021-01450-8
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        Text: English
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    Subjects:
      – SubjectFull: Fluid-structure interaction
        Type: general
      – SubjectFull: Intravascular ultrasonography
        Type: general
      – SubjectFull: Shear flow
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      – SubjectFull: Atherosclerotic plaque
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      – SubjectFull: Fluids
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