A multi-in-one strategy with glucose-triggered long-term antithrombogenicity and sequentially enhanced endothelialization for biological valve leaflets.
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| Title: | A multi-in-one strategy with glucose-triggered long-term antithrombogenicity and sequentially enhanced endothelialization for biological valve leaflets. |
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| Authors: | Wang, Yanan1 (AUTHOR), Ma, Boxuan1 (AUTHOR), Liu, Kunpeng1 (AUTHOR), Luo, Rifang1 (AUTHOR) lrifang@scu.edu.cn, Wang, Yunbing1 (AUTHOR) yunbing.wang@scu.edu.cn |
| Source: | Biomaterials. Aug2021, Vol. 275, pN.PAG-N.PAG. 1p. |
| Subjects: | Bioprosthetic heart valves, Heart valves, Valves, Antithrombins, Oxidation of glucose |
| Abstract: | Bioprosthetic heart valves are commonly applied in heart valve replacement, while the effectiveness is limited by inflammation, calcification and especially thrombosis. Surface modification is expected to endow the biological valves with versatility. Herein, a multi-in-one strategy was established to modify biological valves with long-term antithrombogenicity and sequentially enhanced endothelialization triggered by glucose, in which the direct thrombin inhibitor rivaroxaban (RIVA)-loaded nanogels were embedded and the detachable polyethylene glycol (PEG) was grafted. These two anticoagulant strategies were connected by glucose oxidase (GOx), which catalyzed the oxidation of glucose to produce hydrogen peroxide (H 2 O 2) and local acidic environment. The generated H 2 O 2 stimulated H 2 O 2 -responsive nanogels release RIVA to obtain continuous antithrombogenicity. Meanwhile, PEG was attached to the surface via pH-sensitive bonds, which prevented thrombus formation by resisting the serum proteins and platelets adhesion at the initial stage of material/blood contact. Sequentially, PEG gradually peeled off under the local weak acidic environment, which ultimately resulted in the endothelialization enhancement. Within such multi-in-one strategy, the biological valve leaflets induced long-term anticoagulant performance, gradually enhanced endothelialization and improved tissue affinity, including anti-calcification and anti-inflammation, indicating the potential of the response sequence matching between materials and tissues after implantation, which might improve performance of biological heart valves. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 151608287 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A multi-in-one strategy with glucose-triggered long-term antithrombogenicity and sequentially enhanced endothelialization for biological valve leaflets. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yanan%22">Wang, Yanan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Boxuan%22">Ma, Boxuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Kunpeng%22">Liu, Kunpeng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Rifang%22">Luo, Rifang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lrifang@scu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yunbing%22">Wang, Yunbing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yunbing.wang@scu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Aug2021, Vol. 275, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Bioprosthetic+heart+valves%22">Bioprosthetic heart valves</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+valves%22">Heart valves</searchLink><br /><searchLink fieldCode="DE" term="%22Valves%22">Valves</searchLink><br /><searchLink fieldCode="DE" term="%22Antithrombins%22">Antithrombins</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidation+of+glucose%22">Oxidation of glucose</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Bioprosthetic heart valves are commonly applied in heart valve replacement, while the effectiveness is limited by inflammation, calcification and especially thrombosis. Surface modification is expected to endow the biological valves with versatility. Herein, a multi-in-one strategy was established to modify biological valves with long-term antithrombogenicity and sequentially enhanced endothelialization triggered by glucose, in which the direct thrombin inhibitor rivaroxaban (RIVA)-loaded nanogels were embedded and the detachable polyethylene glycol (PEG) was grafted. These two anticoagulant strategies were connected by glucose oxidase (GOx), which catalyzed the oxidation of glucose to produce hydrogen peroxide (H 2 O 2) and local acidic environment. The generated H 2 O 2 stimulated H 2 O 2 -responsive nanogels release RIVA to obtain continuous antithrombogenicity. Meanwhile, PEG was attached to the surface via pH-sensitive bonds, which prevented thrombus formation by resisting the serum proteins and platelets adhesion at the initial stage of material/blood contact. Sequentially, PEG gradually peeled off under the local weak acidic environment, which ultimately resulted in the endothelialization enhancement. Within such multi-in-one strategy, the biological valve leaflets induced long-term anticoagulant performance, gradually enhanced endothelialization and improved tissue affinity, including anti-calcification and anti-inflammation, indicating the potential of the response sequence matching between materials and tissues after implantation, which might improve performance of biological heart valves. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biomaterials.2021.120981 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Bioprosthetic heart valves Type: general – SubjectFull: Heart valves Type: general – SubjectFull: Valves Type: general – SubjectFull: Antithrombins Type: general – SubjectFull: Oxidation of glucose Type: general Titles: – TitleFull: A multi-in-one strategy with glucose-triggered long-term antithrombogenicity and sequentially enhanced endothelialization for biological valve leaflets. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Yanan – PersonEntity: Name: NameFull: Ma, Boxuan – PersonEntity: Name: NameFull: Liu, Kunpeng – PersonEntity: Name: NameFull: Luo, Rifang – PersonEntity: Name: NameFull: Wang, Yunbing IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 01429612 Numbering: – Type: volume Value: 275 Titles: – TitleFull: Biomaterials Type: main |
| ResultId | 1 |
