Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota.
Saved in:
| Title: | Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota. |
|---|---|
| Authors: | Li, Tian-Tian1,2 (AUTHOR), Huang, Zi-Rui1,2 (AUTHOR), Jia, Rui-Bo1,2 (AUTHOR), Lv, Xu-Cong1,2,3,4 (AUTHOR) xucong1154@163.com, Zhao, Chao1,2 (AUTHOR) zhchao@live.cn, Liu, Bin1,2,3 (AUTHOR) liubin618@hotmail.com |
| Source: | Food Research International. Sep2021, Vol. 147, pN.PAG-N.PAG. 1p. |
| Subjects: | Lipid metabolism disorders, Spirulina platensis, Gut microbiota, Rats, Polysaccharides, Fat, Hyperglycemia |
| Abstract: | [Display omitted] • Spirulina platensis polysaccharides (SPLP) had significant hypolipidemic and hypoglycemic effects in HFD-fed rats. • SPLP intervention modulate the hepatic steatosis and mRNA expressions involved in lipid and carbohydrate metabolism. • SPLP altered the relative abundance of cecal short-chain fatty acids. • SPLP significantly modulated the intestinal microbiota dysbiosis. This study aimed to evaluate the possibility that Spirulina platensis crude polysaccharides may ameliorate the lipid and carbohydrate metabolism disorder, including obesity, hyperlipidemia, hyperglycemia, hepatic steatosis, and gut dysbiosis. The results showed Spirulina platensis crude polysaccharides could improve body weight, serum/liver lipid and carbohydrate indexes, and liver antioxidant parameters in high-sucrose and high-fat diet (HFD)-fed rats, which were accompanied by regulated liver mRNA expressions involved in lipid and carbohydrate metabolism disorder. In addition, SPLP intervention significantly decreased cecal level of propionic acid in HFD-fed rats. Notably, the SPLP could alter the relative abundance of Firmicutes, Bacteroides, Proteobacteria, and Actinobacteria at phylum levels. Based on Spearman's rank correlation coefficient, serum/liver lipid and carbohydrate profiles were found significantly positively correlated with genera Romboutsia , Allobaculum , Blautia , Phascolarctobacterium , Bifidobacterium , Coprococcus , Turicibacter , Erysipelotrichaceae_unclassified , Olsenella , Escherichia/Shigella , Coprobacillus , Lachnospiracea incertae , and Lactobacillus , but strongly negatively correlated with genera Atopostipes , Flavonifractor , Porphyromonadaceae_unclassified , Barnesiella , Oscillibacter , Paraprevotella , Jeotgalicoccus , Corynebacterium , Alloprevotella and Bacteroides. It was concluded that oral administration of SPLP could remarkably ameliorate the lipid and carbohydrate metabolism disorder and significantly modulate the intestinal microbiota in HFD-fed rats. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Research International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 151856712 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Tian-Tian%22">Li, Tian-Tian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Zi-Rui%22">Huang, Zi-Rui</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jia%2C+Rui-Bo%22">Jia, Rui-Bo</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lv%2C+Xu-Cong%22">Lv, Xu-Cong</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<i> xucong1154@163.com</i><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Chao%22">Zhao, Chao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> zhchao@live.cn</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Bin%22">Liu, Bin</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> liubin618@hotmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Food+Research+International%22">Food Research International</searchLink>. Sep2021, Vol. 147, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lipid+metabolism+disorders%22">Lipid metabolism disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Spirulina+platensis%22">Spirulina platensis</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Fat%22">Fat</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperglycemia%22">Hyperglycemia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: [Display omitted] • Spirulina platensis polysaccharides (SPLP) had significant hypolipidemic and hypoglycemic effects in HFD-fed rats. • SPLP intervention modulate the hepatic steatosis and mRNA expressions involved in lipid and carbohydrate metabolism. • SPLP altered the relative abundance of cecal short-chain fatty acids. • SPLP significantly modulated the intestinal microbiota dysbiosis. This study aimed to evaluate the possibility that Spirulina platensis crude polysaccharides may ameliorate the lipid and carbohydrate metabolism disorder, including obesity, hyperlipidemia, hyperglycemia, hepatic steatosis, and gut dysbiosis. The results showed Spirulina platensis crude polysaccharides could improve body weight, serum/liver lipid and carbohydrate indexes, and liver antioxidant parameters in high-sucrose and high-fat diet (HFD)-fed rats, which were accompanied by regulated liver mRNA expressions involved in lipid and carbohydrate metabolism disorder. In addition, SPLP intervention significantly decreased cecal level of propionic acid in HFD-fed rats. Notably, the SPLP could alter the relative abundance of Firmicutes, Bacteroides, Proteobacteria, and Actinobacteria at phylum levels. Based on Spearman's rank correlation coefficient, serum/liver lipid and carbohydrate profiles were found significantly positively correlated with genera Romboutsia , Allobaculum , Blautia , Phascolarctobacterium , Bifidobacterium , Coprococcus , Turicibacter , Erysipelotrichaceae_unclassified , Olsenella , Escherichia/Shigella , Coprobacillus , Lachnospiracea incertae , and Lactobacillus , but strongly negatively correlated with genera Atopostipes , Flavonifractor , Porphyromonadaceae_unclassified , Barnesiella , Oscillibacter , Paraprevotella , Jeotgalicoccus , Corynebacterium , Alloprevotella and Bacteroides. It was concluded that oral administration of SPLP could remarkably ameliorate the lipid and carbohydrate metabolism disorder and significantly modulate the intestinal microbiota in HFD-fed rats. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Food Research International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=151856712 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.foodres.2021.110530 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Lipid metabolism disorders Type: general – SubjectFull: Spirulina platensis Type: general – SubjectFull: Gut microbiota Type: general – SubjectFull: Rats Type: general – SubjectFull: Polysaccharides Type: general – SubjectFull: Fat Type: general – SubjectFull: Hyperglycemia Type: general Titles: – TitleFull: Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Tian-Tian – PersonEntity: Name: NameFull: Huang, Zi-Rui – PersonEntity: Name: NameFull: Jia, Rui-Bo – PersonEntity: Name: NameFull: Lv, Xu-Cong – PersonEntity: Name: NameFull: Zhao, Chao – PersonEntity: Name: NameFull: Liu, Bin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 09639969 Numbering: – Type: volume Value: 147 Titles: – TitleFull: Food Research International Type: main |
| ResultId | 1 |
