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Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition.

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Title: Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition.
Authors: Chen, Yu1 (AUTHOR), Lim, Ja-Yun1,2 (AUTHOR), Wu, Xiang Hua1 (AUTHOR), Heo, June Seok2 (AUTHOR), FengyingYuan3 (AUTHOR), Zhang, Jun Feng1 (AUTHOR) junfengzhang78@126.com, Yoon, Dae Wui1,4 (AUTHOR) ydw@jwu.ac.kr, Ren, Wen Xiu1,3,5 (AUTHOR) xrenwenxiux@hotmail.com
Source: Dyes & Pigments. Nov2021, Vol. 195, pN.PAG-N.PAG. 1p.
Subjects: Fluorescent probes, Cell lines, Liver cells, Liver cancer, Detection limit
Abstract: We designed and synthesized a dual-responsive fluorescent probe MB-N-NAP to detect H 2 S and HClO simultaneously for precise cancer recognition. The probe can concurrently monitor variations in cellular concentrations of H 2 S and HClO with a fast response (in seconds), high sensitivity (detection limits: H 2 S = 0.535 μM, HClO = 2.74 μM), high selectivity, and strong anti-interference. These outstanding properties of MB-N-NAP enabled us to distinguish cancer cells from normal cells successfully. More importantly, MB-N-NAP could specifically recognize liver cancer HepG2 cells from other hepatocarcinoma cells (Hep3B and Huh7), which offers great potential for the accurate cancer diagnosis. [Display omitted] • A dual-responsive fluorescent probe (MB-N-NAP) was designed to reveal the endogenous H 2 S and HClO level of normal cell lines and cancer cell lines. • Among three hepatic cancer cell lines (HepG2, Hep3B and Huh7), MB-N-NAP performed distinctly towards HepG2. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:We designed and synthesized a dual-responsive fluorescent probe MB-N-NAP to detect H 2 S and HClO simultaneously for precise cancer recognition. The probe can concurrently monitor variations in cellular concentrations of H 2 S and HClO with a fast response (in seconds), high sensitivity (detection limits: H 2 S = 0.535 μM, HClO = 2.74 μM), high selectivity, and strong anti-interference. These outstanding properties of MB-N-NAP enabled us to distinguish cancer cells from normal cells successfully. More importantly, MB-N-NAP could specifically recognize liver cancer HepG2 cells from other hepatocarcinoma cells (Hep3B and Huh7), which offers great potential for the accurate cancer diagnosis. [Display omitted] • A dual-responsive fluorescent probe (MB-N-NAP) was designed to reveal the endogenous H 2 S and HClO level of normal cell lines and cancer cell lines. • Among three hepatic cancer cell lines (HepG2, Hep3B and Huh7), MB-N-NAP performed distinctly towards HepG2. [ABSTRACT FROM AUTHOR]
ISSN:01437208
DOI:10.1016/j.dyepig.2021.109666