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Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition.

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Title: Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition.
Authors: Chen, Yu1 (AUTHOR), Lim, Ja-Yun1,2 (AUTHOR), Wu, Xiang Hua1 (AUTHOR), Heo, June Seok2 (AUTHOR), FengyingYuan3 (AUTHOR), Zhang, Jun Feng1 (AUTHOR) junfengzhang78@126.com, Yoon, Dae Wui1,4 (AUTHOR) ydw@jwu.ac.kr, Ren, Wen Xiu1,3,5 (AUTHOR) xrenwenxiux@hotmail.com
Source: Dyes & Pigments. Nov2021, Vol. 195, pN.PAG-N.PAG. 1p.
Subjects: Fluorescent probes, Cell lines, Liver cells, Liver cancer, Detection limit
Abstract: We designed and synthesized a dual-responsive fluorescent probe MB-N-NAP to detect H 2 S and HClO simultaneously for precise cancer recognition. The probe can concurrently monitor variations in cellular concentrations of H 2 S and HClO with a fast response (in seconds), high sensitivity (detection limits: H 2 S = 0.535 μM, HClO = 2.74 μM), high selectivity, and strong anti-interference. These outstanding properties of MB-N-NAP enabled us to distinguish cancer cells from normal cells successfully. More importantly, MB-N-NAP could specifically recognize liver cancer HepG2 cells from other hepatocarcinoma cells (Hep3B and Huh7), which offers great potential for the accurate cancer diagnosis. [Display omitted] • A dual-responsive fluorescent probe (MB-N-NAP) was designed to reveal the endogenous H 2 S and HClO level of normal cell lines and cancer cell lines. • Among three hepatic cancer cell lines (HepG2, Hep3B and Huh7), MB-N-NAP performed distinctly towards HepG2. [ABSTRACT FROM AUTHOR]
Copyright of Dyes & Pigments is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 152272535
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Yu%22">Chen, Yu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lim%2C+Ja-Yun%22">Lim, Ja-Yun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Xiang+Hua%22">Wu, Xiang Hua</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heo%2C+June+Seok%22">Heo, June Seok</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22FengyingYuan%22">FengyingYuan</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jun+Feng%22">Zhang, Jun Feng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> junfengzhang78@126.com</i><br /><searchLink fieldCode="AR" term="%22Yoon%2C+Dae+Wui%22">Yoon, Dae Wui</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> ydw@jwu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Ren%2C+Wen+Xiu%22">Ren, Wen Xiu</searchLink><relatesTo>1,3,5</relatesTo> (AUTHOR)<i> xrenwenxiux@hotmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Dyes+%26+Pigments%22">Dyes & Pigments</searchLink>. Nov2021, Vol. 195, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Fluorescent+probes%22">Fluorescent probes</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+lines%22">Cell lines</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+cells%22">Liver cells</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+cancer%22">Liver cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Detection+limit%22">Detection limit</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: We designed and synthesized a dual-responsive fluorescent probe MB-N-NAP to detect H 2 S and HClO simultaneously for precise cancer recognition. The probe can concurrently monitor variations in cellular concentrations of H 2 S and HClO with a fast response (in seconds), high sensitivity (detection limits: H 2 S = 0.535 μM, HClO = 2.74 μM), high selectivity, and strong anti-interference. These outstanding properties of MB-N-NAP enabled us to distinguish cancer cells from normal cells successfully. More importantly, MB-N-NAP could specifically recognize liver cancer HepG2 cells from other hepatocarcinoma cells (Hep3B and Huh7), which offers great potential for the accurate cancer diagnosis. [Display omitted] • A dual-responsive fluorescent probe (MB-N-NAP) was designed to reveal the endogenous H 2 S and HClO level of normal cell lines and cancer cell lines. • Among three hepatic cancer cell lines (HepG2, Hep3B and Huh7), MB-N-NAP performed distinctly towards HepG2. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Dyes & Pigments is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.dyepig.2021.109666
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      – Code: eng
        Text: English
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      – SubjectFull: Fluorescent probes
        Type: general
      – SubjectFull: Cell lines
        Type: general
      – SubjectFull: Liver cells
        Type: general
      – SubjectFull: Liver cancer
        Type: general
      – SubjectFull: Detection limit
        Type: general
    Titles:
      – TitleFull: Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition.
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            NameFull: Chen, Yu
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            NameFull: Lim, Ja-Yun
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            NameFull: Wu, Xiang Hua
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            NameFull: Heo, June Seok
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            NameFull: FengyingYuan
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            NameFull: Zhang, Jun Feng
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            – D: 01
              M: 11
              Text: Nov2021
              Type: published
              Y: 2021
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              Value: 01437208
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              Value: 195
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