Reusable enzymatic cuvette with heterodyne refractometer for in-vitro glucose concentration measurement.
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| Title: | Reusable enzymatic cuvette with heterodyne refractometer for in-vitro glucose concentration measurement. |
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| Authors: | Hsu, Cheng-Chih1 (AUTHOR) cchsu920624@nuu.edu.tw, Wu, Min-Rui1 (AUTHOR) u0623029@gm.nuu.edu.tw, Hung, Shih-Han1 (AUTHOR) u0723011@gm.nuu.edu.tw, Lee, Ju-Yi2 (AUTHOR) juyilee@ncu.edu.tw, Wu, Chyan-Chyi3 (AUTHOR) ccwu@mail.tku.edu.tw, Dai, Ching-Liang4 (AUTHOR) cldai@dragon.nchu.edu.tw |
| Source: | Optical Engineering. Sep2021, Vol. 60 Issue 9, p94101-94101. 1p. |
| Subjects: | Light sources, Refractometers, Glucose oxidase, Blood sugar, Optical measurements |
| Abstract: | An enzymatic glucose sensor was fabricated and integrated into a heterodyne refractometer. A heterodyne light source was incident into the sensor which the circular birefringence refractive index of sample was changed as the chemical reaction between glucose oxidase and glucose progressed. Therefore, the phase difference before and after chemical reaction could be measured by a lock-in amplifier with phase-lock technology. The optical configuration and measurement procedures indicated that the alignment of the measurement system was straightforward and that it reduced the misalignment effect. The phase stability of the proposed system was superior to 0.04 deg within 1 min. The glucose sensor can be reused 100 times while retaining favorable performance. The results indicated that the resolutions of the proposed method were ∼1.5 and 1.29 mg / dl for the glucose solution and serum-based sample (SRM 965b), respectively. The calibration curve revealed high linearity within the dynamic range of 0 to 300 mg / dl. Based on these findings, the proposed method has a potential to measure the whole blood glucose concentration for daily monitoring. [ABSTRACT FROM AUTHOR] |
| Copyright of Optical Engineering is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 152790472 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Reusable enzymatic cuvette with heterodyne refractometer for in-vitro glucose concentration measurement. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hsu%2C+Cheng-Chih%22">Hsu, Cheng-Chih</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> cchsu920624@nuu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Min-Rui%22">Wu, Min-Rui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> u0623029@gm.nuu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Hung%2C+Shih-Han%22">Hung, Shih-Han</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> u0723011@gm.nuu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Ju-Yi%22">Lee, Ju-Yi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> juyilee@ncu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Chyan-Chyi%22">Wu, Chyan-Chyi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> ccwu@mail.tku.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Dai%2C+Ching-Liang%22">Dai, Ching-Liang</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> cldai@dragon.nchu.edu.tw</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Optical+Engineering%22">Optical Engineering</searchLink>. Sep2021, Vol. 60 Issue 9, p94101-94101. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Light+sources%22">Light sources</searchLink><br /><searchLink fieldCode="DE" term="%22Refractometers%22">Refractometers</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+oxidase%22">Glucose oxidase</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar%22">Blood sugar</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+measurements%22">Optical measurements</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: An enzymatic glucose sensor was fabricated and integrated into a heterodyne refractometer. A heterodyne light source was incident into the sensor which the circular birefringence refractive index of sample was changed as the chemical reaction between glucose oxidase and glucose progressed. Therefore, the phase difference before and after chemical reaction could be measured by a lock-in amplifier with phase-lock technology. The optical configuration and measurement procedures indicated that the alignment of the measurement system was straightforward and that it reduced the misalignment effect. The phase stability of the proposed system was superior to 0.04 deg within 1 min. The glucose sensor can be reused 100 times while retaining favorable performance. The results indicated that the resolutions of the proposed method were ∼1.5 and 1.29 mg / dl for the glucose solution and serum-based sample (SRM 965b), respectively. The calibration curve revealed high linearity within the dynamic range of 0 to 300 mg / dl. Based on these findings, the proposed method has a potential to measure the whole blood glucose concentration for daily monitoring. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Optical Engineering is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1117/1.OE.60.9.094101 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 94101 Subjects: – SubjectFull: Light sources Type: general – SubjectFull: Refractometers Type: general – SubjectFull: Glucose oxidase Type: general – SubjectFull: Blood sugar Type: general – SubjectFull: Optical measurements Type: general Titles: – TitleFull: Reusable enzymatic cuvette with heterodyne refractometer for in-vitro glucose concentration measurement. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hsu, Cheng-Chih – PersonEntity: Name: NameFull: Wu, Min-Rui – PersonEntity: Name: NameFull: Hung, Shih-Han – PersonEntity: Name: NameFull: Lee, Ju-Yi – PersonEntity: Name: NameFull: Wu, Chyan-Chyi – PersonEntity: Name: NameFull: Dai, Ching-Liang IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00913286 Numbering: – Type: volume Value: 60 – Type: issue Value: 9 Titles: – TitleFull: Optical Engineering Type: main |
| ResultId | 1 |
