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Relationship Between Time-Weighted Head Impact Exposure on Directional Changes in Diffusion Imaging in Youth Football Players.

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Title: Relationship Between Time-Weighted Head Impact Exposure on Directional Changes in Diffusion Imaging in Youth Football Players.
Authors: Puvvada, Suraj K.1 (AUTHOR), Davenport, Elizabeth M.2 (AUTHOR), Holcomb, James M.2 (AUTHOR), Miller, Logan E.1 (AUTHOR), Whitlow, Christopher T.1,3 (AUTHOR), Powers, Alexander K.4 (AUTHOR), Maldjian, Joseph A.2 (AUTHOR), Stitzel, Joel D.1 (AUTHOR), Urban, Jillian E.1 (AUTHOR) jurban@wakehealth.edu
Source: Annals of Biomedical Engineering. Oct2021, Vol. 49 Issue 10, p2852-2862. 11p.
Subjects: Head injuries, Football players, Diffusion tensor imaging, Teenagers, Older athletes
Abstract: Approximately 3.5 million youth and adolescents in the US play football, a sport with one of the highest rates of concussion. Repeated subconcussive head impact exposure (HIE) may lead to negative neurological sequelae. To understand HIE as an independent predictive variable, quantitative cumulative kinematic metrics have been developed to capture the volume (i.e., number), severity (i.e., magnitude), and frequency (i.e., time-weighting by the interval between head impacts). In this study, time-weighted cumulative HIE metrics were compared with directional changes in diffusion tensor imaging (DTI) metrics. Changes in DTI conducted on a per-season, per-player basis were assessed as a dependent variable. Directional changes were defined separately as increases and decreases in the number of abnormal voxels relative to non-contact sport controls. Biomechanical and imaging data from 117 athletes (average age 11.9 ± 1.0 years) enrolled in this study was analyzed. Cumulative HIE metrics were more strongly correlated with increases in abnormal voxels than decreases in abnormal voxels. Additionally, across DTI sub-measures, increases and decreases in mean diffusivity (MD) had the strongest relationships with HIE metrics (increases in MD: average R2 = 0.1753, average p = 0.0002; decreases in MD: average R2 = 0.0997, average p = 0.0073). This encourages further investigation into the physiological phenomena represented by directional changes. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Relationship Between Time-Weighted Head Impact Exposure on Directional Changes in Diffusion Imaging in Youth Football Players.
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Oct2021, Vol. 49 Issue 10, p2852-2862. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Head+injuries%22">Head injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Football+players%22">Football players</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Teenagers%22">Teenagers</searchLink><br /><searchLink fieldCode="DE" term="%22Older+athletes%22">Older athletes</searchLink>
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  Data: Approximately 3.5 million youth and adolescents in the US play football, a sport with one of the highest rates of concussion. Repeated subconcussive head impact exposure (HIE) may lead to negative neurological sequelae. To understand HIE as an independent predictive variable, quantitative cumulative kinematic metrics have been developed to capture the volume (i.e., number), severity (i.e., magnitude), and frequency (i.e., time-weighting by the interval between head impacts). In this study, time-weighted cumulative HIE metrics were compared with directional changes in diffusion tensor imaging (DTI) metrics. Changes in DTI conducted on a per-season, per-player basis were assessed as a dependent variable. Directional changes were defined separately as increases and decreases in the number of abnormal voxels relative to non-contact sport controls. Biomechanical and imaging data from 117 athletes (average age 11.9 ± 1.0 years) enrolled in this study was analyzed. Cumulative HIE metrics were more strongly correlated with increases in abnormal voxels than decreases in abnormal voxels. Additionally, across DTI sub-measures, increases and decreases in mean diffusivity (MD) had the strongest relationships with HIE metrics (increases in MD: average R2 = 0.1753, average p = 0.0002; decreases in MD: average R2 = 0.0997, average p = 0.0073). This encourages further investigation into the physiological phenomena represented by directional changes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10439-021-02862-4
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        Text: English
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      – TitleFull: Relationship Between Time-Weighted Head Impact Exposure on Directional Changes in Diffusion Imaging in Youth Football Players.
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              Text: Oct2021
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