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Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia.

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Title: Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia.
Authors: Beebe, Nigel W.1,2 n.beebe@uq.edu.au, Pagendam, Dan2, Trewin, Brendan J.2, Boomer, Andrew2, Bradford, Matt2, Ford, Andrew2, Liddington, Catherine2, Bondarenco, Artiom2, De Barro, Paul J.2, Gilchrist, Joshua2, Paton, Christopher3, Staunton, Kyran M.3,4, Johnson, Brian5, Maynard, Andrew J.1, Devine, Gregor J.5, Hugo, Leon E.5, Rasic, Gordana5, Cook, Helen6, Massaro, Peter7, Snoad, Nigel7
Source: Proceedings of the National Academy of Sciences of the United States of America. 10/12/2021, Vol. 118 Issue 41, p1-12. 12p.
Subjects: Aedes aegypti, Aedes albopictus, Rural population, Mosquito control, Mosquito vectors, Agricultural laborers
Geographic Terms: Queensland, Australia
Abstract: Releasing sterile or incompatible male insects is a proven method of population management in agricultural systems with the potential to revolutionize mosquito control. Through a collaborative venture with the "Debug" Verily Life Sciences team, we assessed the incompatible insect technique (IIT) with the mosquito vector Aedes aegypti in northern Australia in a replicated treatment control field trial. Backcrossing a US strain of Ae. aegypti carrying Wolbachia wAlbB from Aedes albopictus with a local strain, we generated a wAlbB2-F4 strain incompatible with both the wild-type (no Wolbachia) and wMel-Wolbachia Ae. aegypti now extant in North Queensland. The wAlbB2-F4 strain was manually mass reared with males separated from females using Verily sex-sorting technologies to obtain no detectable female contamination in the field. With community consent, we delivered a total of three million IIT males into three isolated landscapes of over 200 houses each, releasing ~50 males per house three times a week over 20 wk. Detecting initial overflooding ratios of between 5:1 and 10:1, strong population declines well beyond 80% were detected across all treatment landscapes when compared to controls. Monitoring through the following season to observe the ongoing effect saw one treatment landscape devoid of adult Ae. aegypti early in the season. A second landscape showed reduced adults, and the third recovered fully. These encouraging results in suppressing both wild-type and wMel-Ae. aegypti confirms the utility of bidirectional incompatibility in the field setting, show the IIT to be robust, and indicate that the removal of this arbovirus vector from human-occupied landscapes may be achievable. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia.
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  Data: <searchLink fieldCode="AR" term="%22Beebe%2C+Nigel+W%2E%22">Beebe, Nigel W.</searchLink><relatesTo>1,2</relatesTo><i> n.beebe@uq.edu.au</i><br /><searchLink fieldCode="AR" term="%22Pagendam%2C+Dan%22">Pagendam, Dan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Trewin%2C+Brendan+J%2E%22">Trewin, Brendan J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Boomer%2C+Andrew%22">Boomer, Andrew</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bradford%2C+Matt%22">Bradford, Matt</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ford%2C+Andrew%22">Ford, Andrew</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Liddington%2C+Catherine%22">Liddington, Catherine</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bondarenco%2C+Artiom%22">Bondarenco, Artiom</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22De+Barro%2C+Paul+J%2E%22">De Barro, Paul J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gilchrist%2C+Joshua%22">Gilchrist, Joshua</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Paton%2C+Christopher%22">Paton, Christopher</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Staunton%2C+Kyran+M%2E%22">Staunton, Kyran M.</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Johnson%2C+Brian%22">Johnson, Brian</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Maynard%2C+Andrew+J%2E%22">Maynard, Andrew J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Devine%2C+Gregor+J%2E%22">Devine, Gregor J.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Hugo%2C+Leon+E%2E%22">Hugo, Leon E.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Rasic%2C+Gordana%22">Rasic, Gordana</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Cook%2C+Helen%22">Cook, Helen</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Massaro%2C+Peter%22">Massaro, Peter</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Snoad%2C+Nigel%22">Snoad, Nigel</searchLink><relatesTo>7</relatesTo>
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  Data: Releasing sterile or incompatible male insects is a proven method of population management in agricultural systems with the potential to revolutionize mosquito control. Through a collaborative venture with the "Debug" Verily Life Sciences team, we assessed the incompatible insect technique (IIT) with the mosquito vector Aedes aegypti in northern Australia in a replicated treatment control field trial. Backcrossing a US strain of Ae. aegypti carrying Wolbachia wAlbB from Aedes albopictus with a local strain, we generated a wAlbB2-F4 strain incompatible with both the wild-type (no Wolbachia) and wMel-Wolbachia Ae. aegypti now extant in North Queensland. The wAlbB2-F4 strain was manually mass reared with males separated from females using Verily sex-sorting technologies to obtain no detectable female contamination in the field. With community consent, we delivered a total of three million IIT males into three isolated landscapes of over 200 houses each, releasing ~50 males per house three times a week over 20 wk. Detecting initial overflooding ratios of between 5:1 and 10:1, strong population declines well beyond 80% were detected across all treatment landscapes when compared to controls. Monitoring through the following season to observe the ongoing effect saw one treatment landscape devoid of adult Ae. aegypti early in the season. A second landscape showed reduced adults, and the third recovered fully. These encouraging results in suppressing both wild-type and wMel-Ae. aegypti confirms the utility of bidirectional incompatibility in the field setting, show the IIT to be robust, and indicate that the removal of this arbovirus vector from human-occupied landscapes may be achievable. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1073/pnas.2106828118
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        Text: English
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      – SubjectFull: Aedes aegypti
        Type: general
      – SubjectFull: Aedes albopictus
        Type: general
      – SubjectFull: Rural population
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      – SubjectFull: Mosquito control
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      – SubjectFull: Agricultural laborers
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      – SubjectFull: Queensland
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      – SubjectFull: Australia
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