Diagnosis and Simultaneous Treatment of Musculoskeletal Injury Using H 2 O 2 -Triggered Echogenic Antioxidant Polymer Nanoparticles in a Rat Model of Contusion Injury.
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| Title: | Diagnosis and Simultaneous Treatment of Musculoskeletal Injury Using H 2 O 2 -Triggered Echogenic Antioxidant Polymer Nanoparticles in a Rat Model of Contusion Injury. |
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| Authors: | Kim, Gi-Wook1,2 (AUTHOR) k26@jbnu.ac.kr, Song, Nan-Hee3 (AUTHOR) nanhee9710@gmail.com, Park, Mi-Ran3 (AUTHOR) anne0189@naver.com, Kim, Tae-Eon3 (AUTHOR) rotqhf94@jbnu.ac.kr, Kim, Da-Sol1,2 (AUTHOR), Oh, Young-Bin4 (AUTHOR) youngbiin@hanmail.net, Lee, Dong-Won3,5 (AUTHOR) k26@jbnu.ac.kr |
| Source: | Nanomaterials (2079-4991). Oct2021, Vol. 11 Issue 10, p2571. 1p. |
| Subjects: | Animal disease models, Musculoskeletal system injuries, Contrast-enhanced ultrasound, Contrast media, Musculoskeletal system diseases, Musculoskeletal system |
| Abstract: | Ultrasound is clinically used for diagnosis and interventions for musculoskeletal injuries like muscle contusion, but contrast of ultrasonography still remains a challenge in the field of the musculoskeletal system. A level of hydrogen peroxide (H2O2) is known to be elevated during mechanical tissue damage and therefore H2O2 can be exploited as a diagnostic and therapeutic marker for mechanical injuries in the musculoskeletal system. We previously developed poly(vanillin-oxalate) (PVO) as an inflammation-responsive polymeric prodrug of vanillin, which is designed to rapidly respond to H2O2 and exert antioxidant and anti-inflammatory activities. The primary aim of this study is to verify whether PVO nanoparticles could serve as contrast agents as well as therapeutic agents for musculoskeletal injuries simultaneously. In a rat model of contusion-induced muscle injury, PVO nanoparticles generated CO2 bubbles to enhance the ultrasound contrast in the injury site. A single intramuscular injection of PVO nanoparticles also suppressed contusion-induced muscle damages by inhibiting the expression of pro-inflammatory cytokines and inflammatory cell infiltration. We, therefore, anticipate that PVO nanoparticles have great translational potential as not only ultrasound imaging agents but also therapeutic agents for the musculoskeletal disorders such as contusion. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 153310538 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Diagnosis and Simultaneous Treatment of Musculoskeletal Injury Using H 2 O 2 -Triggered Echogenic Antioxidant Polymer Nanoparticles in a Rat Model of Contusion Injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Gi-Wook%22">Kim, Gi-Wook</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> k26@jbnu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Song%2C+Nan-Hee%22">Song, Nan-Hee</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> nanhee9710@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Park%2C+Mi-Ran%22">Park, Mi-Ran</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> anne0189@naver.com</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Tae-Eon%22">Kim, Tae-Eon</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> rotqhf94@jbnu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Da-Sol%22">Kim, Da-Sol</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oh%2C+Young-Bin%22">Oh, Young-Bin</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> youngbiin@hanmail.net</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Dong-Won%22">Lee, Dong-Won</searchLink><relatesTo>3,5</relatesTo> (AUTHOR)<i> k26@jbnu.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Oct2021, Vol. 11 Issue 10, p2571. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Animal+disease+models%22">Animal disease models</searchLink><br /><searchLink fieldCode="DE" term="%22Musculoskeletal+system+injuries%22">Musculoskeletal system injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast-enhanced+ultrasound%22">Contrast-enhanced ultrasound</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Musculoskeletal+system+diseases%22">Musculoskeletal system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Musculoskeletal+system%22">Musculoskeletal system</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Ultrasound is clinically used for diagnosis and interventions for musculoskeletal injuries like muscle contusion, but contrast of ultrasonography still remains a challenge in the field of the musculoskeletal system. A level of hydrogen peroxide (H2O2) is known to be elevated during mechanical tissue damage and therefore H2O2 can be exploited as a diagnostic and therapeutic marker for mechanical injuries in the musculoskeletal system. We previously developed poly(vanillin-oxalate) (PVO) as an inflammation-responsive polymeric prodrug of vanillin, which is designed to rapidly respond to H2O2 and exert antioxidant and anti-inflammatory activities. The primary aim of this study is to verify whether PVO nanoparticles could serve as contrast agents as well as therapeutic agents for musculoskeletal injuries simultaneously. In a rat model of contusion-induced muscle injury, PVO nanoparticles generated CO2 bubbles to enhance the ultrasound contrast in the injury site. A single intramuscular injection of PVO nanoparticles also suppressed contusion-induced muscle damages by inhibiting the expression of pro-inflammatory cytokines and inflammatory cell infiltration. We, therefore, anticipate that PVO nanoparticles have great translational potential as not only ultrasound imaging agents but also therapeutic agents for the musculoskeletal disorders such as contusion. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano11102571 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 2571 Subjects: – SubjectFull: Animal disease models Type: general – SubjectFull: Musculoskeletal system injuries Type: general – SubjectFull: Contrast-enhanced ultrasound Type: general – SubjectFull: Contrast media Type: general – SubjectFull: Musculoskeletal system diseases Type: general – SubjectFull: Musculoskeletal system Type: general Titles: – TitleFull: Diagnosis and Simultaneous Treatment of Musculoskeletal Injury Using H 2 O 2 -Triggered Echogenic Antioxidant Polymer Nanoparticles in a Rat Model of Contusion Injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Gi-Wook – PersonEntity: Name: NameFull: Song, Nan-Hee – PersonEntity: Name: NameFull: Park, Mi-Ran – PersonEntity: Name: NameFull: Kim, Tae-Eon – PersonEntity: Name: NameFull: Kim, Da-Sol – PersonEntity: Name: NameFull: Oh, Young-Bin – PersonEntity: Name: NameFull: Lee, Dong-Won IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 11 – Type: issue Value: 10 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
