Needle-Free Jet Injectors' Geometry Design and Drug Diffusion Process Analysis.
Saved in:
| Title: | Needle-Free Jet Injectors' Geometry Design and Drug Diffusion Process Analysis. |
|---|---|
| Authors: | Wang, Yunfei1 (AUTHOR), Yue, Long1 (AUTHOR), Hu, Lechuan2 (AUTHOR), Wang, Jing3 (AUTHOR) |
| Source: | Applied Bionics & Biomechanics. 11/8/2021, p1-6. 6p. |
| Subjects: | Diffusion processes, Drug design, Injectors, Geometry, Ellipsoids |
| Abstract: | In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse. [ABSTRACT FROM AUTHOR] |
| Copyright of Applied Bionics & Biomechanics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 153458555 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Needle-Free Jet Injectors' Geometry Design and Drug Diffusion Process Analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yunfei%22">Wang, Yunfei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yue%2C+Long%22">Yue, Long</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Lechuan%22">Hu, Lechuan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jing%22">Wang, Jing</searchLink><relatesTo>3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Bionics+%26+Biomechanics%22">Applied Bionics & Biomechanics</searchLink>. 11/8/2021, p1-6. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diffusion+processes%22">Diffusion processes</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+design%22">Drug design</searchLink><br /><searchLink fieldCode="DE" term="%22Injectors%22">Injectors</searchLink><br /><searchLink fieldCode="DE" term="%22Geometry%22">Geometry</searchLink><br /><searchLink fieldCode="DE" term="%22Ellipsoids%22">Ellipsoids</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Bionics & Biomechanics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=153458555 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/2021/5199278 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1 Subjects: – SubjectFull: Diffusion processes Type: general – SubjectFull: Drug design Type: general – SubjectFull: Injectors Type: general – SubjectFull: Geometry Type: general – SubjectFull: Ellipsoids Type: general Titles: – TitleFull: Needle-Free Jet Injectors' Geometry Design and Drug Diffusion Process Analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Yunfei – PersonEntity: Name: NameFull: Yue, Long – PersonEntity: Name: NameFull: Hu, Lechuan – PersonEntity: Name: NameFull: Wang, Jing IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 11 Text: 11/8/2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 11762322 Titles: – TitleFull: Applied Bionics & Biomechanics Type: main |
| ResultId | 1 |
