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Interactions of chemical components in ambient PM2.5 with influenza viruses.

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Title: Interactions of chemical components in ambient PM2.5 with influenza viruses.
Authors: Hsiao, Ta-Chih1 (AUTHOR) tchsiao@ntu.edu.tw, Cheng, Po-Ching1,2,3 (AUTHOR) bonjovi@tmu.edu.tw, Chi, Kai Hsien4 (AUTHOR) khchi2@ym.edu.tw, Wang, Hung-Yang2,3 (AUTHOR) shatroll8447@outlook.com, Pan, Shih-Yu4 (AUTHOR) shelly.pan923@hotmail.com, Kao, Ching5 (AUTHOR) kaoxching@gmail.com, Lee, Yueh-Lun6 (AUTHOR) yllee@tmu.edu.tw, Kuo, Han-Pin7 (AUTHOR) q8828@tmu.edu.tw, Chung, Kian Fan8 (AUTHOR) f.chung@imperial.ac.uk, Chuang, Hsiao-Chi1,5,9,10 (AUTHOR) chuanghc@tmu.edu.t
Source: Journal of Hazardous Materials. Feb2022:Part B, Vol. 423, pN.PAG-N.PAG. 1p.
Subjects: Influenza viruses, Influenza A virus, Influenza B virus, Virus diseases, Influenza, Complementary DNA
Geographic Terms: Taipei (Taiwan)
Abstract: The significance of this work is that ambient PM 2.5 is a direct transmission mode for influenza virus infection to the human alveolar epithelium. The concentration of PM 2.5 was 11.7 ± 5.5 μg/m3 in Taipei during 24 December 2019–13 January 2020. Approximately 79% of inhaled PM 2.5 is able to reach the upper-to-lower airway, and 47% of PM 2.5 is able to reach the alveolar epithelium for influenza virus infection. Influenza A and B viruses were detected in PM 2.5 on 9 days, and the influenza A/H5 virus was detected on 15 days during the study period. FL and Pyr were negatively correlated with the influenza A virus. D(ah)P and Acp were positively correlated with the influenza B and A/H5 viruses, respectively. Cd, V, and Zn were positively correlated with the influenza A, B, and A/H5 viruses, respectively. Next, influenza A, B, and A/H5 viral plasmids interacted with carbon black, H 2 O 2 , DEPs, and UD. We observed that H 2 O 2 significantly decreased levels of complementary DNA of the three influenza viruses. DEPs and UD significantly decreased influenza A and A/H5 viral levels. In conclusion, chemicals in PM 2.5 may play vital roles in terms of viable influenza virus in the atmosphere. [Display omitted] • Ambient PM 2.5 is a direct transmission mode for influenza virus infection. • Approximately 47% contagious PM 2.5 is able to reach human alveoli. • The chemicals of PM 2.5 modified the structure of the influenza virus gene. • ROS may decrease the level of virus on the PM 2.5. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:The significance of this work is that ambient PM 2.5 is a direct transmission mode for influenza virus infection to the human alveolar epithelium. The concentration of PM 2.5 was 11.7 ± 5.5 μg/m3 in Taipei during 24 December 2019–13 January 2020. Approximately 79% of inhaled PM 2.5 is able to reach the upper-to-lower airway, and 47% of PM 2.5 is able to reach the alveolar epithelium for influenza virus infection. Influenza A and B viruses were detected in PM 2.5 on 9 days, and the influenza A/H5 virus was detected on 15 days during the study period. FL and Pyr were negatively correlated with the influenza A virus. D(ah)P and Acp were positively correlated with the influenza B and A/H5 viruses, respectively. Cd, V, and Zn were positively correlated with the influenza A, B, and A/H5 viruses, respectively. Next, influenza A, B, and A/H5 viral plasmids interacted with carbon black, H 2 O 2 , DEPs, and UD. We observed that H 2 O 2 significantly decreased levels of complementary DNA of the three influenza viruses. DEPs and UD significantly decreased influenza A and A/H5 viral levels. In conclusion, chemicals in PM 2.5 may play vital roles in terms of viable influenza virus in the atmosphere. [Display omitted] • Ambient PM 2.5 is a direct transmission mode for influenza virus infection. • Approximately 47% contagious PM 2.5 is able to reach human alveoli. • The chemicals of PM 2.5 modified the structure of the influenza virus gene. • ROS may decrease the level of virus on the PM 2.5. [ABSTRACT FROM AUTHOR]
ISSN:03043894
DOI:10.1016/j.jhazmat.2021.127243