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Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay.

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Title: Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay.
Authors: Mujtaba, Muhammad1 (AUTHOR) muhammadmujtaba443@gmail.com, Yilmaz, Bahar Akyuz2 (AUTHOR), Cansaran-Duman, Demet1 (AUTHOR), Akyuz, Lalehan3 (AUTHOR), Yangın, Sevcan1 (AUTHOR), Kaya, Murat2 (AUTHOR), Çeter, Talip4 (AUTHOR), Khawar, Khalid Mahmood5 (AUTHOR)
Source: Polymer Bulletin. Jan2022, Vol. 79 Issue 1, p519-540. 22p.
Subjects: Austrian pine, Sporopollenin, Oxaliplatin, Cell death, Myc oncogenes, Antineoplastic agents
Abstract: Sporopollenin-mediated control drug delivery has been studied extensively owing to its desirable physicochemical and biological properties. Herein, sporopollenin was successfully extracted from C. libani and P. nigra pollens followed by loading of a commonly known anticancer drug Oxaliplatin. Drug loading and physicochemical features were confirmed by using light microscopy, FT-IR, SEM and TGA. For the first-time, real-time cell analyzer system xCELLigence was employed to record the Oxaliplatin loaded sporopollenin-mediated cell death (CaCo-2 and Vero cells) in real time. Both the release assays confirmed the slow release of oxaliplatin from sporopollenin for around 40–45 h. The expression of MYC and FOXO-3 genes has been significantly increased in CaCo2 cell and decreased non-cancerous Vero cell confirming the fact that sporopollenin-mediated control release of oxaliplatin is promoting apoptosis cell death preventing the spread of negative effects on nearby healthy cells. All the results suggested that C. libani and P. nigra can be suitable candidates for the slow delivery of drugs. [ABSTRACT FROM AUTHOR]
Copyright of Polymer Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay.
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  Data: <searchLink fieldCode="AR" term="%22Mujtaba%2C+Muhammad%22">Mujtaba, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> muhammadmujtaba443@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Yilmaz%2C+Bahar+Akyuz%22">Yilmaz, Bahar Akyuz</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cansaran-Duman%2C+Demet%22">Cansaran-Duman, Demet</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akyuz%2C+Lalehan%22">Akyuz, Lalehan</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yangın%2C+Sevcan%22">Yangın, Sevcan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaya%2C+Murat%22">Kaya, Murat</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Çeter%2C+Talip%22">Çeter, Talip</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khawar%2C+Khalid+Mahmood%22">Khawar, Khalid Mahmood</searchLink><relatesTo>5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Polymer+Bulletin%22">Polymer Bulletin</searchLink>. Jan2022, Vol. 79 Issue 1, p519-540. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Austrian+pine%22">Austrian pine</searchLink><br /><searchLink fieldCode="DE" term="%22Sporopollenin%22">Sporopollenin</searchLink><br /><searchLink fieldCode="DE" term="%22Oxaliplatin%22">Oxaliplatin</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+death%22">Cell death</searchLink><br /><searchLink fieldCode="DE" term="%22Myc+oncogenes%22">Myc oncogenes</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Sporopollenin-mediated control drug delivery has been studied extensively owing to its desirable physicochemical and biological properties. Herein, sporopollenin was successfully extracted from C. libani and P. nigra pollens followed by loading of a commonly known anticancer drug Oxaliplatin. Drug loading and physicochemical features were confirmed by using light microscopy, FT-IR, SEM and TGA. For the first-time, real-time cell analyzer system xCELLigence was employed to record the Oxaliplatin loaded sporopollenin-mediated cell death (CaCo-2 and Vero cells) in real time. Both the release assays confirmed the slow release of oxaliplatin from sporopollenin for around 40–45 h. The expression of MYC and FOXO-3 genes has been significantly increased in CaCo2 cell and decreased non-cancerous Vero cell confirming the fact that sporopollenin-mediated control release of oxaliplatin is promoting apoptosis cell death preventing the spread of negative effects on nearby healthy cells. All the results suggested that C. libani and P. nigra can be suitable candidates for the slow delivery of drugs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymer Bulletin is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00289-020-03531-7
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        Text: English
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        PageCount: 22
        StartPage: 519
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      – SubjectFull: Austrian pine
        Type: general
      – SubjectFull: Sporopollenin
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      – SubjectFull: Oxaliplatin
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      – SubjectFull: Cell death
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      – SubjectFull: Myc oncogenes
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      – SubjectFull: Antineoplastic agents
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      – TitleFull: Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay.
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              Text: Jan2022
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              Y: 2022
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