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Photobiomodulation and Sida tuberculata combination declines the inflammation's markers in knee-induced osteoarthritis.

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Title: Photobiomodulation and Sida tuberculata combination declines the inflammation's markers in knee-induced osteoarthritis.
Authors: Yamada, Eloá Ferreira1 (AUTHOR) eloayamada@gmail.com, dos Santos Stein, Carolina2 (AUTHOR), Moresco, Rafael Noal2 (AUTHOR), Bobinski, Franciane3 (AUTHOR), Palandi, Juliete3,4 (AUTHOR), Fernandes, Paula Franson3 (AUTHOR), Folmer, Vanderlei1 (AUTHOR), da Silva, Morgana Duarte1 (AUTHOR)
Source: Lasers in Medical Science. Feb2022, Vol. 37 Issue 1, p193-204. 12p.
Subjects: Knee, Photobiomodulation therapy, Knee osteoarthritis, Oxidative stress, Nitrites, Osteoarthritis, Inflammation, Nitric oxide
Abstract: The aim of this study was to assess potential combination effects of photobiomodulation therapy (PBMT) with Sida tuberculata extracts on the oxidative stress and antioxidant activity, as well as on the inflammatory process. Rats with knee osteoarthritis (OA) were treated with S. tuberculata extracts and PBMT (904 nm, 18 J/cm2). The animals were evaluated for nociception and edema. The blood, knee lavage and structures, spinal cord, and brainstem were collected for biochemical analyses (lipid peroxidation, protein carbonyl content, superoxide dismutase activity, non-protein thiol levels, and measurement of nitrite/nitrate). The knee structures were also used to measure cytokine levels. PBMT lowered the damage due to oxidative stress in the knee and at distant sites from the lesion. PBMT also reduced the levels of nitric oxide and cytokines, which could explain the nociception reduction mechanism. Similarly, S. tuberculata decreased the damage by oxidative stress, levels of nitrite/nitrate, and cytokines. The therapy combination reduced levels of cytokines and nitrite/nitrate. PBMT and S. tuberculata extracts reduced the oxidative stress and inflammation. It is noteworthy that PBMT increased the antioxidant activity in the knee and at sites distant from the lesion, contributing to a more significant decrease in nociception. The combination of therapies did not present significant effects on the analyzed parameters. Therefore, it is suggested that PBM is sufficient to minimize the signs and symptoms of the knee OA in our rat model. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Photobiomodulation and Sida tuberculata combination declines the inflammation's markers in knee-induced osteoarthritis.
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  Data: <searchLink fieldCode="AR" term="%22Yamada%2C+Eloá+Ferreira%22">Yamada, Eloá Ferreira</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> eloayamada@gmail.com</i><br /><searchLink fieldCode="AR" term="%22dos+Santos+Stein%2C+Carolina%22">dos Santos Stein, Carolina</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moresco%2C+Rafael+Noal%22">Moresco, Rafael Noal</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bobinski%2C+Franciane%22">Bobinski, Franciane</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palandi%2C+Juliete%22">Palandi, Juliete</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fernandes%2C+Paula+Franson%22">Fernandes, Paula Franson</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Folmer%2C+Vanderlei%22">Folmer, Vanderlei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22da+Silva%2C+Morgana+Duarte%22">da Silva, Morgana Duarte</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. Feb2022, Vol. 37 Issue 1, p193-204. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Knee%22">Knee</searchLink><br /><searchLink fieldCode="DE" term="%22Photobiomodulation+therapy%22">Photobiomodulation therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Knee+osteoarthritis%22">Knee osteoarthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Nitrites%22">Nitrites</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoarthritis%22">Osteoarthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Nitric+oxide%22">Nitric oxide</searchLink>
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  Data: The aim of this study was to assess potential combination effects of photobiomodulation therapy (PBMT) with Sida tuberculata extracts on the oxidative stress and antioxidant activity, as well as on the inflammatory process. Rats with knee osteoarthritis (OA) were treated with S. tuberculata extracts and PBMT (904 nm, 18 J/cm2). The animals were evaluated for nociception and edema. The blood, knee lavage and structures, spinal cord, and brainstem were collected for biochemical analyses (lipid peroxidation, protein carbonyl content, superoxide dismutase activity, non-protein thiol levels, and measurement of nitrite/nitrate). The knee structures were also used to measure cytokine levels. PBMT lowered the damage due to oxidative stress in the knee and at distant sites from the lesion. PBMT also reduced the levels of nitric oxide and cytokines, which could explain the nociception reduction mechanism. Similarly, S. tuberculata decreased the damage by oxidative stress, levels of nitrite/nitrate, and cytokines. The therapy combination reduced levels of cytokines and nitrite/nitrate. PBMT and S. tuberculata extracts reduced the oxidative stress and inflammation. It is noteworthy that PBMT increased the antioxidant activity in the knee and at sites distant from the lesion, contributing to a more significant decrease in nociception. The combination of therapies did not present significant effects on the analyzed parameters. Therefore, it is suggested that PBM is sufficient to minimize the signs and symptoms of the knee OA in our rat model. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10103-020-03207-8
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 193
    Subjects:
      – SubjectFull: Knee
        Type: general
      – SubjectFull: Photobiomodulation therapy
        Type: general
      – SubjectFull: Knee osteoarthritis
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Nitrites
        Type: general
      – SubjectFull: Osteoarthritis
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Nitric oxide
        Type: general
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      – TitleFull: Photobiomodulation and Sida tuberculata combination declines the inflammation's markers in knee-induced osteoarthritis.
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              Text: Feb2022
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