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Uncovering the dynamics of a circadian-dopamine model influenced by the light–dark cycle.

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Title: Uncovering the dynamics of a circadian-dopamine model influenced by the light–dark cycle.
Authors: Kim, Ruby1 (AUTHOR) rubykim@math.duke.edu, Witelski, Thomas P.1 (AUTHOR)
Source: Mathematical Biosciences. Feb2022, Vol. 344, pN.PAG-N.PAG. 1p.
Subjects: Parkinson's disease, Circadian rhythms, Health behavior, Dopamine, Affective disorders, Differential equations, Dopamine receptors
Abstract: The neurotransmitter dopamine (DA) is known to be influenced by the circadian timekeeping system in the mammalian brain. We have previously created a single-cell differential equations model to understand the mechanisms behind circadian rhythms of extracellular DA. In this paper, we investigate the dynamics in our model and study different behaviors such as entrainment to the 24-hour light–dark cycle and robust periodicity versus decoupling, quasiperiodicity, and chaos. Imbalances in DA are often accompanied by disrupted circadian rhythms, such as in Parkinson's disease, hyperactivity, and mood disorders. Our model provides new insights into the links between the circadian clock and DA. We show that the daily rhythmicity of DA can be disrupted by decoupling between interlocked loops of the clock circuitry or by quasiperiodic clock behaviors caused by misalignment with the light–dark cycle. The model can be used to further study how the circadian clock affects the dopaminergic system, and to help develop therapeutic strategies for disrupted DA rhythms. • Mathematical model provides new insights into circadian modulation of dopamine. • Decoupling in the light-entrained model disrupts daily variation of dopamine. • Low light variation is linked to quasiperiodic behaviors with health consequences. • Sufficiently strong light variation creates large regions of entrainment. [ABSTRACT FROM AUTHOR]
Copyright of Mathematical Biosciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 155103364
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  Data: Uncovering the dynamics of a circadian-dopamine model influenced by the light–dark cycle.
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Ruby%22">Kim, Ruby</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rubykim@math.duke.edu</i><br /><searchLink fieldCode="AR" term="%22Witelski%2C+Thomas+P%2E%22">Witelski, Thomas P.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Mathematical+Biosciences%22">Mathematical Biosciences</searchLink>. Feb2022, Vol. 344, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Circadian+rhythms%22">Circadian rhythms</searchLink><br /><searchLink fieldCode="DE" term="%22Health+behavior%22">Health behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Differential+equations%22">Differential equations</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The neurotransmitter dopamine (DA) is known to be influenced by the circadian timekeeping system in the mammalian brain. We have previously created a single-cell differential equations model to understand the mechanisms behind circadian rhythms of extracellular DA. In this paper, we investigate the dynamics in our model and study different behaviors such as entrainment to the 24-hour light–dark cycle and robust periodicity versus decoupling, quasiperiodicity, and chaos. Imbalances in DA are often accompanied by disrupted circadian rhythms, such as in Parkinson's disease, hyperactivity, and mood disorders. Our model provides new insights into the links between the circadian clock and DA. We show that the daily rhythmicity of DA can be disrupted by decoupling between interlocked loops of the clock circuitry or by quasiperiodic clock behaviors caused by misalignment with the light–dark cycle. The model can be used to further study how the circadian clock affects the dopaminergic system, and to help develop therapeutic strategies for disrupted DA rhythms. • Mathematical model provides new insights into circadian modulation of dopamine. • Decoupling in the light-entrained model disrupts daily variation of dopamine. • Low light variation is linked to quasiperiodic behaviors with health consequences. • Sufficiently strong light variation creates large regions of entrainment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Mathematical Biosciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/j.mbs.2021.108764
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Circadian rhythms
        Type: general
      – SubjectFull: Health behavior
        Type: general
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Affective disorders
        Type: general
      – SubjectFull: Differential equations
        Type: general
      – SubjectFull: Dopamine receptors
        Type: general
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      – TitleFull: Uncovering the dynamics of a circadian-dopamine model influenced by the light–dark cycle.
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            NameFull: Kim, Ruby
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            NameFull: Witelski, Thomas P.
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            – D: 01
              M: 02
              Text: Feb2022
              Type: published
              Y: 2022
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              Value: 344
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