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T1D‐weighted ihMT imaging – Part II. Investigating the long‐ and short‐T1D components correlation with myelin content. Comparison with R1 and the macromolecular proton fraction.

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Title: T1D‐weighted ihMT imaging – Part II. Investigating the long‐ and short‐T1D components correlation with myelin content. Comparison with R1 and the macromolecular proton fraction.
Authors: Hertanu, Andreea1,2 (AUTHOR), Soustelle, Lucas1,2 (AUTHOR), Buron, Julie1,2,3 (AUTHOR), Le Priellec, Julie3 (AUTHOR), Cayre, Myriam3 (AUTHOR), Le Troter, Arnaud1,2 (AUTHOR), Varma, Gopal4 (AUTHOR), Alsop, David C.4 (AUTHOR), Durbec, Pascale3 (AUTHOR), Girard, Olivier M.1,2 (AUTHOR), Duhamel, Guillaume1,2 (AUTHOR) guillaume.duhamel@univ-amu.fr
Source: Magnetic Resonance in Medicine. May2022, Vol. 87 Issue 5, p2329-2346. 18p.
Subjects: Myelin, Magnetization transfer, Histological techniques, Protons, Reference values
Abstract: Purpose: To investigate the long‐ and short‐T1D components correlation with myelin content using inhomogeneous magnetization transfer (ihMT) high‐pass and band‐pass T1D‐filters and to compare ihMT, R1, and the macromolecular proton fraction (MPF) for myelin specific imaging. Methods: The 3D ihMT rapid gradient echo (ihMTRAGE) sequences with increasing switching times (Δt) were used to derive ihMT high‐pass T1D‐filters with increasing T1D cutoff values and an ihMT band‐pass T1D‐filter for components in the 100 µs to 1 ms range. 3D spoiled gradient echo quantitative MT (SPGR‐qMT) protocols were used to derive R1 and MPF maps. The specificity of R1, MPF, and ihMT T1D‐filters was evaluated by comparison with two histological reference techniques for myelin imaging. Results: The higher contribution of long‐T1Ds as compared to the short components as Δt got longer led to an increase in the specificity to myelination. In contrast, focusing on the signal originating from a narrow range of short‐T1Ds (< 1 ms) as isolated by the band‐pass T1D‐filter led to lower specificity. In addition, the significantly lower r2 correlation coefficient of the band‐pass T1D‐filter suggests that the origin of short‐T1D components is mostly associated with non‐myelin protons. Also, the important contribution of short‐T1Ds to the estimated MPF, explains its low specificity to myelination as compared to the ihMT high‐pass T1D‐filters. Conclusion: Long‐T1D components imaging by means of ihMT high‐pass T1D‐filters is proposed as an MRI biomarker for myelin content. Future studies should enable the investigation of the sensitivity of ihMT T1D‐filters for demyelinating processes. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: T&lt;subscript&gt;1D&lt;/subscript&gt;‐weighted ihMT imaging – Part II. Investigating the long‐ and short‐T&lt;subscript&gt;1D&lt;/subscript&gt; components correlation with myelin content. Comparison with R&lt;subscript&gt;1&lt;/subscript&gt; and the macromolecular proton fraction.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hertanu%2C+Andreea%22&quot;&gt;Hertanu, Andreea&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Soustelle%2C+Lucas%22&quot;&gt;Soustelle, Lucas&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Buron%2C+Julie%22&quot;&gt;Buron, Julie&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Le+Priellec%2C+Julie%22&quot;&gt;Le Priellec, Julie&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cayre%2C+Myriam%22&quot;&gt;Cayre, Myriam&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Le+Troter%2C+Arnaud%22&quot;&gt;Le Troter, Arnaud&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Varma%2C+Gopal%22&quot;&gt;Varma, Gopal&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alsop%2C+David+C%2E%22&quot;&gt;Alsop, David C.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Durbec%2C+Pascale%22&quot;&gt;Durbec, Pascale&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Girard%2C+Olivier+M%2E%22&quot;&gt;Girard, Olivier M.&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Duhamel%2C+Guillaume%22&quot;&gt;Duhamel, Guillaume&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; guillaume.duhamel@univ-amu.fr&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. May2022, Vol. 87 Issue 5, p2329-2346. 18p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myelin%22&quot;&gt;Myelin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetization+transfer%22&quot;&gt;Magnetization transfer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Histological+techniques%22&quot;&gt;Histological techniques&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Protons%22&quot;&gt;Protons&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Reference+values%22&quot;&gt;Reference values&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Purpose: To investigate the long‐ and short‐T1D components correlation with myelin content using inhomogeneous magnetization transfer (ihMT) high‐pass and band‐pass T1D‐filters and to compare ihMT, R1, and the macromolecular proton fraction (MPF) for myelin specific imaging. Methods: The 3D ihMT rapid gradient echo (ihMTRAGE) sequences with increasing switching times (Δt) were used to derive ihMT high‐pass T1D‐filters with increasing T1D cutoff values and an ihMT band‐pass T1D‐filter for components in the 100 &#181;s to 1 ms range. 3D spoiled gradient echo quantitative MT (SPGR‐qMT) protocols were used to derive R1 and MPF maps. The specificity of R1, MPF, and ihMT T1D‐filters was evaluated by comparison with two histological reference techniques for myelin imaging. Results: The higher contribution of long‐T1Ds as compared to the short components as Δt got longer led to an increase in the specificity to myelination. In contrast, focusing on the signal originating from a narrow range of short‐T1Ds (&lt; 1 ms) as isolated by the band‐pass T1D‐filter led to lower specificity. In addition, the significantly lower r2 correlation coefficient of the band‐pass T1D‐filter suggests that the origin of short‐T1D components is mostly associated with non‐myelin protons. Also, the important contribution of short‐T1Ds to the estimated MPF, explains its low specificity to myelination as compared to the ihMT high‐pass T1D‐filters. Conclusion: Long‐T1D components imaging by means of ihMT high‐pass T1D‐filters is proposed as an MRI biomarker for myelin content. Future studies should enable the investigation of the sensitivity of ihMT T1D‐filters for demyelinating processes. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.29140
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 2329
    Subjects:
      – SubjectFull: Myelin
        Type: general
      – SubjectFull: Magnetization transfer
        Type: general
      – SubjectFull: Histological techniques
        Type: general
      – SubjectFull: Protons
        Type: general
      – SubjectFull: Reference values
        Type: general
    Titles:
      – TitleFull: T1D‐weighted ihMT imaging – Part II. Investigating the long‐ and short‐T1D components correlation with myelin content. Comparison with R1 and the macromolecular proton fraction.
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              M: 05
              Text: May2022
              Type: published
              Y: 2022
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