Pain pathways and potential new targets for pain relief.
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| Title: | Pain pathways and potential new targets for pain relief. |
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| Authors: | Menglan Wang1, Thyagarajan, Baskaran1 Thyagarajan@uwyo.edu |
| Source: | Biotechnology & Applied Biochemistry. Feb2022, Vol. 69 Issue 1, p110-123. 14p. |
| Subjects: | Nociceptors, TRP channels, Sodium channels, Analgesia, Central nervous system, Opioid receptors, Calcium channels, Sensory neurons |
| Abstract: | Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of people on a daily basis. Sensory neurons known as nociceptors built specifically to detect damaging stimuli can be found throughout the body. They transmit information about noxious stimuli from mechanical, thermal, and chemical sources to the central nervous system and higher brain centers via electrical signals. Nociceptors express various channels and receptors such as voltage-gated sodium and calcium channels, transient receptor potential channels, and opioid receptors that allow them to respond in a highly specific manner to noxious stimuli. Attenuating the pain response can be achieved by inhibiting or altering the expression of these pain targets. Achieving a deeper understanding of how these receptors can be affected at the molecular level can lead to the development of novel pain therapies. This review will discuss the mechanisms of pain, introduce the various receptors that are responsible for detecting pain, and future directions in pharmacological therapies. [ABSTRACT FROM AUTHOR] |
| Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 155899687 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pain pathways and potential new targets for pain relief. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Menglan+Wang%22">Menglan Wang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Thyagarajan%2C+Baskaran%22">Thyagarajan, Baskaran</searchLink><relatesTo>1</relatesTo><i> Thyagarajan@uwyo.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biotechnology+%26+Applied+Biochemistry%22">Biotechnology & Applied Biochemistry</searchLink>. Feb2022, Vol. 69 Issue 1, p110-123. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nociceptors%22">Nociceptors</searchLink><br /><searchLink fieldCode="DE" term="%22TRP+channels%22">TRP channels</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium+channels%22">Sodium channels</searchLink><br /><searchLink fieldCode="DE" term="%22Analgesia%22">Analgesia</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Opioid+receptors%22">Opioid receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+channels%22">Calcium channels</searchLink><br /><searchLink fieldCode="DE" term="%22Sensory+neurons%22">Sensory neurons</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of people on a daily basis. Sensory neurons known as nociceptors built specifically to detect damaging stimuli can be found throughout the body. They transmit information about noxious stimuli from mechanical, thermal, and chemical sources to the central nervous system and higher brain centers via electrical signals. Nociceptors express various channels and receptors such as voltage-gated sodium and calcium channels, transient receptor potential channels, and opioid receptors that allow them to respond in a highly specific manner to noxious stimuli. Attenuating the pain response can be achieved by inhibiting or altering the expression of these pain targets. Achieving a deeper understanding of how these receptors can be affected at the molecular level can lead to the development of novel pain therapies. This review will discuss the mechanisms of pain, introduce the various receptors that are responsible for detecting pain, and future directions in pharmacological therapies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/bab.2086 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 110 Subjects: – SubjectFull: Nociceptors Type: general – SubjectFull: TRP channels Type: general – SubjectFull: Sodium channels Type: general – SubjectFull: Analgesia Type: general – SubjectFull: Central nervous system Type: general – SubjectFull: Opioid receptors Type: general – SubjectFull: Calcium channels Type: general – SubjectFull: Sensory neurons Type: general Titles: – TitleFull: Pain pathways and potential new targets for pain relief. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Menglan Wang – PersonEntity: Name: NameFull: Thyagarajan, Baskaran IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 08854513 Numbering: – Type: volume Value: 69 – Type: issue Value: 1 Titles: – TitleFull: Biotechnology & Applied Biochemistry Type: main |
| ResultId | 1 |
