Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii.
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| Title: | Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii. |
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| Authors: | Whiteway, Clémence1,2 (AUTHOR), Valcek, Adam1,2 (AUTHOR), Philippe, Chantal3 (AUTHOR), Strazisar, Mojca4,5 (AUTHOR), De Pooter, Tim4,5 (AUTHOR), Mateus, Ivan6 (AUTHOR), Breine, Anke1,2 (AUTHOR), Van der Henst, Charles1,2 (AUTHOR) charles.vanderhenst@vub.vib.be |
| Source: | ISME Journal: Multidisciplinary Journal of Microbial Ecology. May2022, Vol. 16 Issue 5, p1473-1477. 5p. |
| Abstract: | We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance. [ABSTRACT FROM AUTHOR] |
| Copyright of ISME Journal: Multidisciplinary Journal of Microbial Ecology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 156500527 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41396-021-01179-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1473 Titles: – TitleFull: Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Whiteway, Clémence – PersonEntity: Name: NameFull: Valcek, Adam – PersonEntity: Name: NameFull: Philippe, Chantal – PersonEntity: Name: NameFull: Strazisar, Mojca – PersonEntity: Name: NameFull: De Pooter, Tim – PersonEntity: Name: NameFull: Mateus, Ivan – PersonEntity: Name: NameFull: Breine, Anke – PersonEntity: Name: NameFull: Van der Henst, Charles IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 17517362 Numbering: – Type: volume Value: 16 – Type: issue Value: 5 Titles: – TitleFull: ISME Journal: Multidisciplinary Journal of Microbial Ecology Type: main |
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