View in EDS PDF Full Text

Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience.

Saved in:
Bibliographic Details
Title: Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience.
Authors: Brix, Gunnar1,2 gbrix@bfs.de, Henze, Marcus3, Knopp, Michael V.1, Lucht, Robert2, Doll, Josef1, Junkermann, Hans4, Hawighorst, Hans1, Haberkorn, Uwe1,3, Brix, G1 (AUTHOR), Henze, M (AUTHOR), Knopp, M V (AUTHOR), Lucht, R (AUTHOR), Doll, J (AUTHOR), Junkermann, H (AUTHOR), Hawighorst, H (AUTHOR), Haberkorn, U (AUTHOR)
Source: European Radiology. Oct2001, Vol. 11 Issue 10, p2058-2070. 13p.
Subjects: Medical imaging systems, Pharmacokinetics, Positron emission tomography, Cancer invasiveness, Diagnostic imaging, Medical radiography
Abstract: It was the aim of this methodology-oriented clinical pilot study to compare the potential of dynamic MRI and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) for the detection and characterization of breast cancer. Fourteen women with suspicious breast lesions were examined. The MRI data were acquired with a turbo fast low-angle shot sequence and analyzed using a pharmacokinetic model. Emission data were detected in the sensitive 3D modus, iteratively reconstructed, and superimposed onto corresponding transmission images. In the 14 patients, 13 breast masses with a suspicious contrast enhancement and FDG uptake were detected. For these lesions, no statistically significant correlation between evaluated MR and PET parameters was found. Of the 9 histologically confirmed carcinomas, 8 were correctly characterized with MRI and PET. Two inflammatory lesions were concordantly classified as cancer. Moreover, dynamic MRI yielded another false-positive finding. In 6 patients, PET detected occult lymph node and/or distant metastases. Although both functional imaging techniques provide independent tissue information, the results concerning the diagnosis of primary breast lesions were almost identical. An advantage of PET, however, is its ability to localize lymph node involvement and distant metastases as an integral part of the examination. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 15654546
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Brix%2C+Gunnar%22">Brix, Gunnar</searchLink><relatesTo>1,2</relatesTo><i> gbrix@bfs.de</i><br /><searchLink fieldCode="AR" term="%22Henze%2C+Marcus%22">Henze, Marcus</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Knopp%2C+Michael+V%2E%22">Knopp, Michael V.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lucht%2C+Robert%22">Lucht, Robert</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Doll%2C+Josef%22">Doll, Josef</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Junkermann%2C+Hans%22">Junkermann, Hans</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Hawighorst%2C+Hans%22">Hawighorst, Hans</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Haberkorn%2C+Uwe%22">Haberkorn, Uwe</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Brix%2C+G%22">Brix, G</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Henze%2C+M%22">Henze, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Knopp%2C+M+V%22">Knopp, M V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lucht%2C+R%22">Lucht, R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doll%2C+J%22">Doll, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Junkermann%2C+H%22">Junkermann, H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hawighorst%2C+H%22">Hawighorst, H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haberkorn%2C+U%22">Haberkorn, U</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Oct2001, Vol. 11 Issue 10, p2058-2070. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacokinetics%22">Pharmacokinetics</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+radiography%22">Medical radiography</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: It was the aim of this methodology-oriented clinical pilot study to compare the potential of dynamic MRI and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) for the detection and characterization of breast cancer. Fourteen women with suspicious breast lesions were examined. The MRI data were acquired with a turbo fast low-angle shot sequence and analyzed using a pharmacokinetic model. Emission data were detected in the sensitive 3D modus, iteratively reconstructed, and superimposed onto corresponding transmission images. In the 14 patients, 13 breast masses with a suspicious contrast enhancement and FDG uptake were detected. For these lesions, no statistically significant correlation between evaluated MR and PET parameters was found. Of the 9 histologically confirmed carcinomas, 8 were correctly characterized with MRI and PET. Two inflammatory lesions were concordantly classified as cancer. Moreover, dynamic MRI yielded another false-positive finding. In 6 patients, PET detected occult lymph node and/or distant metastases. Although both functional imaging techniques provide independent tissue information, the results concerning the diagnosis of primary breast lesions were almost identical. An advantage of PET, however, is its ability to localize lymph node involvement and distant metastases as an integral part of the examination. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=15654546
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s003300100944
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 2058
    Subjects:
      – SubjectFull: Medical imaging systems
        Type: general
      – SubjectFull: Pharmacokinetics
        Type: general
      – SubjectFull: Positron emission tomography
        Type: general
      – SubjectFull: Cancer invasiveness
        Type: general
      – SubjectFull: Diagnostic imaging
        Type: general
      – SubjectFull: Medical radiography
        Type: general
    Titles:
      – TitleFull: Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Brix, Gunnar
      – PersonEntity:
          Name:
            NameFull: Henze, Marcus
      – PersonEntity:
          Name:
            NameFull: Knopp, Michael V.
      – PersonEntity:
          Name:
            NameFull: Lucht, Robert
      – PersonEntity:
          Name:
            NameFull: Doll, Josef
      – PersonEntity:
          Name:
            NameFull: Junkermann, Hans
      – PersonEntity:
          Name:
            NameFull: Hawighorst, Hans
      – PersonEntity:
          Name:
            NameFull: Haberkorn, Uwe
      – PersonEntity:
          Name:
            NameFull: Brix, G
      – PersonEntity:
          Name:
            NameFull: Henze, M
      – PersonEntity:
          Name:
            NameFull: Knopp, M V
      – PersonEntity:
          Name:
            NameFull: Lucht, R
      – PersonEntity:
          Name:
            NameFull: Doll, J
      – PersonEntity:
          Name:
            NameFull: Junkermann, H
      – PersonEntity:
          Name:
            NameFull: Hawighorst, H
      – PersonEntity:
          Name:
            NameFull: Haberkorn, U
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2001
              Type: published
              Y: 2001
          Identifiers:
            – Type: issn-print
              Value: 09387994
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: European Radiology
              Type: main
ResultId 1