Hyperpolarized 129Xe imaging of the brain: Achievements and future challenges.
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| Title: | Hyperpolarized 129Xe imaging of the brain: Achievements and future challenges. |
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| Authors: | Shepelytskyi, Yurii1,2 (AUTHOR), Grynko, Vira2,3 (AUTHOR), Rao, Madhwesha R.4 (AUTHOR), Li, Tao1 (AUTHOR), Agostino, Martina1 (AUTHOR), Wild, Jim M.4,5 (AUTHOR), Albert, Mitchell S.1,2,6 (AUTHOR) malbert1@lakeheadu.ca |
| Source: | Magnetic Resonance in Medicine. Jul2022, Vol. 88 Issue 1, p83-105. 23p. |
| Subjects: | Brain imaging, Magnetic resonance imaging, Perfusion imaging, Alzheimer's patients, Blood flow |
| Abstract: | Hyperpolarized (HP) xenon‐129 (129Xe) brain MRI is a promising imaging modality currently under extensive development. HP 129Xe is nontoxic, capable of dissolving in pulmonary blood, and is extremely sensitive to the local environment. After dissolution in the pulmonary blood, HP 129Xe travels with the blood flow to the brain and can be used for functional imaging such as perfusion imaging, hemodynamic response detection, and blood–brain barrier permeability assessment. HP 129Xe MRI imaging of the brain has been performed in animals, healthy human subjects, and in patients with Alzheimer's disease and stroke. In this review, the overall progress in the field of HP 129Xe brain imaging is discussed, along with various imaging approaches and pulse sequences used to optimize HP 129Xe brain MRI. In addition, current challenges and limitations of HP 129Xe brain imaging are discussed, as well as possible methods for their mitigation. Finally, potential pathways for further development are also discussed. HP 129Xe MRI of the brain has the potential to become a valuable novel perfusion imaging technique and has the potential to be used in the clinical setting in the future. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 156556649 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hyperpolarized <superscript>129</superscript>Xe imaging of the brain: Achievements and future challenges. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shepelytskyi%2C+Yurii%22">Shepelytskyi, Yurii</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grynko%2C+Vira%22">Grynko, Vira</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rao%2C+Madhwesha+R%2E%22">Rao, Madhwesha R.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Tao%22">Li, Tao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Agostino%2C+Martina%22">Agostino, Martina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wild%2C+Jim+M%2E%22">Wild, Jim M.</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Albert%2C+Mitchell+S%2E%22">Albert, Mitchell S.</searchLink><relatesTo>1,2,6</relatesTo> (AUTHOR)<i> malbert1@lakeheadu.ca</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jul2022, Vol. 88 Issue 1, p83-105. 23p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Perfusion+imaging%22">Perfusion imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+flow%22">Blood flow</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Hyperpolarized (HP) xenon‐129 (129Xe) brain MRI is a promising imaging modality currently under extensive development. HP 129Xe is nontoxic, capable of dissolving in pulmonary blood, and is extremely sensitive to the local environment. After dissolution in the pulmonary blood, HP 129Xe travels with the blood flow to the brain and can be used for functional imaging such as perfusion imaging, hemodynamic response detection, and blood–brain barrier permeability assessment. HP 129Xe MRI imaging of the brain has been performed in animals, healthy human subjects, and in patients with Alzheimer's disease and stroke. In this review, the overall progress in the field of HP 129Xe brain imaging is discussed, along with various imaging approaches and pulse sequences used to optimize HP 129Xe brain MRI. In addition, current challenges and limitations of HP 129Xe brain imaging are discussed, as well as possible methods for their mitigation. Finally, potential pathways for further development are also discussed. HP 129Xe MRI of the brain has the potential to become a valuable novel perfusion imaging technique and has the potential to be used in the clinical setting in the future. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.29200 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 23 StartPage: 83 Subjects: – SubjectFull: Brain imaging Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Perfusion imaging Type: general – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Blood flow Type: general Titles: – TitleFull: Hyperpolarized 129Xe imaging of the brain: Achievements and future challenges. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shepelytskyi, Yurii – PersonEntity: Name: NameFull: Grynko, Vira – PersonEntity: Name: NameFull: Rao, Madhwesha R. – PersonEntity: Name: NameFull: Li, Tao – PersonEntity: Name: NameFull: Agostino, Martina – PersonEntity: Name: NameFull: Wild, Jim M. – PersonEntity: Name: NameFull: Albert, Mitchell S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 88 – Type: issue Value: 1 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
