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Smart bioelectronic pacifier for real-time continuous monitoring of salivary electrolytes.

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Title: Smart bioelectronic pacifier for real-time continuous monitoring of salivary electrolytes.
Authors: Lim, Hyo-Ryoung1 (AUTHOR), Lee, Soon Min1,2 (AUTHOR), Park, Sehyun1,3,4 (AUTHOR), Choi, Chanyeong4,5 (AUTHOR), Kim, Hojoong4,5 (AUTHOR), Kim, Jihoon4,5 (AUTHOR), Mahmood, Musa4,5 (AUTHOR), Lee, Yongkuk6 (AUTHOR), Kim, Jong-Hoon1,3 (AUTHOR) jh.kim@wsu.edu, Yeo, Woon-Hong1,4,5,7,8 (AUTHOR) whyeo@gatech.edu
Source: Biosensors & Bioelectronics. Aug2022, Vol. 210, pN.PAG-N.PAG. 1p.
Subjects: Electrolytes, Neonatal intensive care, Water-electrolyte balance (Physiology), Flexible printed circuits, Intensive care units, Saliva
Abstract: Monitoring electrolytes is critical for newborns and babies in the intensive care unit. However, the gold standard methods use a blood draw, which is painful and only offers discrete measures. Although salivary-based detection offers promise as an alternative, existing devices are ineffective for real-time, continuous monitoring of electrolytes due to their rigidity, bulky form factors, and lack of salivary accumulation. Here, we introduce a smart, wireless, bioelectronic pacifier for salivary electrolyte monitoring of neonates, which can detect real-time continuous sodium and potassium levels without a blood draw. The miniature system facilitates the seamless integration of the ultralight and low-profile device with a commercial pacifier without additional fixtures or structural modifications. The portable device includes ion-selective sensors, flexible circuits, and microfluidic channels, allowing simplified measurement protocols in non-invasive electrolyte monitoring. The flexible microfluidic channel enables continuous and efficient saliva collection from a mouth. By modifying the surface properties of the channels and the structure of the capillary reservoir, we achieve reliable pumping of the viscous medium for quick calibration and measurement. Embedded sensors in the system show good stability and sensitivity: 52 and 57 mV/decade for the sodium and potassium sensor, respectively. In vivo study with neonates in the intensive care unit captures the device's feasibility and performance in the natural saliva-based detection of the critical electrolytes without induced stimulation. [ABSTRACT FROM AUTHOR]
Copyright of Biosensors & Bioelectronics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 156942848
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Smart bioelectronic pacifier for real-time continuous monitoring of salivary electrolytes.
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  Data: <searchLink fieldCode="AR" term="%22Lim%2C+Hyo-Ryoung%22">Lim, Hyo-Ryoung</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Soon+Min%22">Lee, Soon Min</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Sehyun%22">Park, Sehyun</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Chanyeong%22">Choi, Chanyeong</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Hojoong%22">Kim, Hojoong</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Jihoon%22">Kim, Jihoon</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahmood%2C+Musa%22">Mahmood, Musa</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Yongkuk%22">Lee, Yongkuk</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Jong-Hoon%22">Kim, Jong-Hoon</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> jh.kim@wsu.edu</i><br /><searchLink fieldCode="AR" term="%22Yeo%2C+Woon-Hong%22">Yeo, Woon-Hong</searchLink><relatesTo>1,4,5,7,8</relatesTo> (AUTHOR)<i> whyeo@gatech.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Biosensors+%26+Bioelectronics%22">Biosensors & Bioelectronics</searchLink>. Aug2022, Vol. 210, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Electrolytes%22">Electrolytes</searchLink><br /><searchLink fieldCode="DE" term="%22Neonatal+intensive+care%22">Neonatal intensive care</searchLink><br /><searchLink fieldCode="DE" term="%22Water-electrolyte+balance+%28Physiology%29%22">Water-electrolyte balance (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Flexible+printed+circuits%22">Flexible printed circuits</searchLink><br /><searchLink fieldCode="DE" term="%22Intensive+care+units%22">Intensive care units</searchLink><br /><searchLink fieldCode="DE" term="%22Saliva%22">Saliva</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Monitoring electrolytes is critical for newborns and babies in the intensive care unit. However, the gold standard methods use a blood draw, which is painful and only offers discrete measures. Although salivary-based detection offers promise as an alternative, existing devices are ineffective for real-time, continuous monitoring of electrolytes due to their rigidity, bulky form factors, and lack of salivary accumulation. Here, we introduce a smart, wireless, bioelectronic pacifier for salivary electrolyte monitoring of neonates, which can detect real-time continuous sodium and potassium levels without a blood draw. The miniature system facilitates the seamless integration of the ultralight and low-profile device with a commercial pacifier without additional fixtures or structural modifications. The portable device includes ion-selective sensors, flexible circuits, and microfluidic channels, allowing simplified measurement protocols in non-invasive electrolyte monitoring. The flexible microfluidic channel enables continuous and efficient saliva collection from a mouth. By modifying the surface properties of the channels and the structure of the capillary reservoir, we achieve reliable pumping of the viscous medium for quick calibration and measurement. Embedded sensors in the system show good stability and sensitivity: 52 and 57 mV/decade for the sodium and potassium sensor, respectively. In vivo study with neonates in the intensive care unit captures the device's feasibility and performance in the natural saliva-based detection of the critical electrolytes without induced stimulation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biosensors & Bioelectronics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.bios.2022.114329
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Electrolytes
        Type: general
      – SubjectFull: Neonatal intensive care
        Type: general
      – SubjectFull: Water-electrolyte balance (Physiology)
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      – SubjectFull: Flexible printed circuits
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      – SubjectFull: Intensive care units
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      – SubjectFull: Saliva
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      – TitleFull: Smart bioelectronic pacifier for real-time continuous monitoring of salivary electrolytes.
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              Text: Aug2022
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