Diffusion tensor imaging of partial intractable epilepsy.

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Bibliographic Details
Title:	Diffusion tensor imaging of partial intractable epilepsy.
Authors:	de la Roque, Anne Dumas¹, Oppenheim, Catherine¹ oppenheim@chsa.broca.inserm.fr, Chassoux, Francine², Rodrigo, Sebastian¹, Beuvon, Frédéric³, Daumas-Duport, Catherine³, Devaux, Bertrand², Meder, Jean-François¹
Source:	European Radiology. Feb2005, Vol. 15 Issue 2, p279-285. 7p.
Subjects:	Epilepsy, Brain, Medical imaging systems, Diagnostic imaging, Radiology, Medical research
Abstract:	Our aim was to assess the value of diffusion tensor imaging (DTI) in patients with partial intractable epilepsy. We used DTI (25 non-collinear directions) in 15 patients with a cortical lesion on conventional MRI. Fractional anisotropy (FA) was measured in the internal capsule, and in the normal-appearing white matter (WM),adjacent tothe lesion, andaway fromthe lesion, at a set distance of 2-3 cm. In each patient, increased or decreased FA measurements were those that varied from mirror values using an arbitrary 10% threshold. Over the whole population, ipsi- and contralateral FA measurements were also compared using a Wilcoxon test (p<0.05). Over the whole population, FA was significantly reduced in the WMadjacent toandaway fromthe lesion, whilst being normal in the internal capsule. FA was reduced by more than 10% in the WMadjacent toanddistant fromthe lesion in 13 and 12 patients respectively. For nine of the ten patients for whom the surgical resection encompassed the limits of the lesion on conventional MRI, histological data showed WM alterations (gliosis, axonal loss, abnormal cells). DTI often reveals WM abnormalities that are undetected on conventional MRI in patients with partial intractable epilepsy. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

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Abstract:	Our aim was to assess the value of diffusion tensor imaging (DTI) in patients with partial intractable epilepsy. We used DTI (25 non-collinear directions) in 15 patients with a cortical lesion on conventional MRI. Fractional anisotropy (FA) was measured in the internal capsule, and in the normal-appearing white matter (WM),adjacent tothe lesion, andaway fromthe lesion, at a set distance of 2-3 cm. In each patient, increased or decreased FA measurements were those that varied from mirror values using an arbitrary 10% threshold. Over the whole population, ipsi- and contralateral FA measurements were also compared using a Wilcoxon test (p<0.05). Over the whole population, FA was significantly reduced in the WMadjacent toandaway fromthe lesion, whilst being normal in the internal capsule. FA was reduced by more than 10% in the WMadjacent toanddistant fromthe lesion in 13 and 12 patients respectively. For nine of the ten patients for whom the surgical resection encompassed the limits of the lesion on conventional MRI, histological data showed WM alterations (gliosis, axonal loss, abnormal cells). DTI often reveals WM abnormalities that are undetected on conventional MRI in patients with partial intractable epilepsy. [ABSTRACT FROM AUTHOR]
ISSN:	09387994
DOI:	10.1007/s00330-004-2578-8