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Examining lung microstructure using 19F MR diffusion imaging in COPD patients.

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Title: Examining lung microstructure using 19F MR diffusion imaging in COPD patients.
Authors: Obert, Arnd Jonathan1,2 (AUTHOR), Gutberlet, Marcel1,2 (AUTHOR), Kern, Agilo Luitger1,2 (AUTHOR), Kaireit, Till Frederik1,2 (AUTHOR), Glandorf, Julian1,2 (AUTHOR), Moher Alsady, Tawfik1,2 (AUTHOR), Wacker, Frank1,2 (AUTHOR), Hohlfeld, Jens Michael2,3,4 (AUTHOR), Vogel‐Claussen, Jens1,2 (AUTHOR) vogel-claussen.jens@mh-hannover.de
Source: Magnetic Resonance in Medicine. Aug2022, Vol. 88 Issue 2, p860-870. 11p.
Subjects: Magnetic resonance imaging, Chronic obstructive pulmonary disease, Diffusion magnetic resonance imaging, Diffusion measurements, Forced expiratory volume
Abstract: Purpose: To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease. Methods: Diffusion of fluorinated gas in the short‐time regime was measured using multiple gradient‐echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface‐to‐volume ratio was calculated using a first‐order approximation of the time‐dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized 129Xe diffusion MRI and lung function testing was analyzed. Results: Using 19F diffusion MRI, the median surface‐to‐volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm−1 [87–144 cm−1]) compared with healthy volunteers (S/V = 164 cm−1 [160–84 cm−1], p < 0.0001). No significant difference was found between measurements within 7 days for healthy (p = 0.88, median coefficient of variation = 4.3%) and diseased subjects (p = 0.58, median coefficient of variation= 6.7%). Linear correlations were found with S/V from 129Xe diffusion MRI (r = 0.85, p = 0.001) and the forced expiratory volume in 1 second (r = 0.68, p < 0.0001). Conclusion: Examination of lung microstructure using time‐dependent diffusion measurement of inhaled 19F is feasible, repeatable, and correlates with established measurements. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Examining lung microstructure using &lt;superscript&gt;19&lt;/superscript&gt;F MR diffusion imaging in COPD patients.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Aug2022, Vol. 88 Issue 2, p860-870. 11p.
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  Label: Abstract
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  Data: Purpose: To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease. Methods: Diffusion of fluorinated gas in the short‐time regime was measured using multiple gradient‐echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface‐to‐volume ratio was calculated using a first‐order approximation of the time‐dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized 129Xe diffusion MRI and lung function testing was analyzed. Results: Using 19F diffusion MRI, the median surface‐to‐volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm−1 [87–144 cm−1]) compared with healthy volunteers (S/V = 164 cm−1 [160–84 cm−1], p &lt; 0.0001). No significant difference was found between measurements within 7 days for healthy (p = 0.88, median coefficient of variation = 4.3%) and diseased subjects (p = 0.58, median coefficient of variation= 6.7%). Linear correlations were found with S/V from 129Xe diffusion MRI (r = 0.85, p = 0.001) and the forced expiratory volume in 1 second (r = 0.68, p &lt; 0.0001). Conclusion: Examination of lung microstructure using time‐dependent diffusion measurement of inhaled 19F is feasible, repeatable, and correlates with established measurements. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.29237
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        Text: English
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      – SubjectFull: Chronic obstructive pulmonary disease
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              Text: Aug2022
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