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Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens.

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Title: Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens.
Authors: Pink, Harry1 (AUTHOR), Talbot, Adam1 (AUTHOR), Graceson, Abi2 (AUTHOR), Graham, Juliane2 (AUTHOR), Higgins, Gill1 (AUTHOR), Taylor, Andrew3 (AUTHOR), Jackson, Alison C.3 (AUTHOR), Truco, Maria4 (AUTHOR), Michelmore, Richard4 (AUTHOR), Yao, Chenyi5 (AUTHOR), Gawthrop, Frances5 (AUTHOR), Pink, David2 (AUTHOR), Hand, Paul2 (AUTHOR), Clarkson, John P.3 (AUTHOR), Denby, Katherine1 (AUTHOR) Katherine.denby@york.ac.uk
Source: Theoretical & Applied Genetics. Jul2022, Vol. 135 Issue 7, p2481-2500. 20p.
Subjects: Lettuce, Locus (Genetics), Edible greens, Genetic regulation, Fungicide resistance, Genetic variation
Abstract: Key message: We demonstrate genetic variation for quantitative resistance against important fungal pathogens in lettuce and its wild relatives, map loci conferring resistance and predict key molecular mechanisms using transcriptome profiling. Lactuca sativa L. (lettuce) is an important leafy vegetable crop grown and consumed globally. Chemicals are routinely used to control major pathogens, including the causal agents of grey mould (Botrytis cinerea) and lettuce drop (Sclerotinia sclerotiorum). With increasing prevalence of pathogen resistance to fungicides and environmental concerns, there is an urgent need to identify sources of genetic resistance to B. cinerea and S. sclerotiorum in lettuce. We demonstrated genetic variation for quantitative resistance to B. cinerea and S. sclerotiorum in a set of 97 diverse lettuce and wild relative accessions, and between the parents of lettuce mapping populations. Transcriptome profiling across multiple lettuce accessions enabled us to identify genes with expression correlated with resistance, predicting the importance of post-transcriptional gene regulation in the lettuce defence response. We identified five genetic loci influencing quantitative resistance in a F6 mapping population derived from a Lactuca serriola (wild relative) × lettuce cross, which each explained 5–10% of the variation. Differential gene expression analysis between the parent lines, and integration of data on correlation of gene expression and resistance in the diversity set, highlighted potential causal genes underlying the quantitative trait loci. [ABSTRACT FROM AUTHOR]
Copyright of Theoretical & Applied Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens.
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  Data: <searchLink fieldCode="AR" term="%22Pink%2C+Harry%22">Pink, Harry</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Talbot%2C+Adam%22">Talbot, Adam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Graceson%2C+Abi%22">Graceson, Abi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Graham%2C+Juliane%22">Graham, Juliane</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Higgins%2C+Gill%22">Higgins, Gill</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taylor%2C+Andrew%22">Taylor, Andrew</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jackson%2C+Alison+C%2E%22">Jackson, Alison C.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Truco%2C+Maria%22">Truco, Maria</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michelmore%2C+Richard%22">Michelmore, Richard</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yao%2C+Chenyi%22">Yao, Chenyi</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gawthrop%2C+Frances%22">Gawthrop, Frances</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pink%2C+David%22">Pink, David</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hand%2C+Paul%22">Hand, Paul</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clarkson%2C+John+P%2E%22">Clarkson, John P.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Denby%2C+Katherine%22">Denby, Katherine</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Katherine.denby@york.ac.uk</i>
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  Data: Key message: We demonstrate genetic variation for quantitative resistance against important fungal pathogens in lettuce and its wild relatives, map loci conferring resistance and predict key molecular mechanisms using transcriptome profiling. Lactuca sativa L. (lettuce) is an important leafy vegetable crop grown and consumed globally. Chemicals are routinely used to control major pathogens, including the causal agents of grey mould (Botrytis cinerea) and lettuce drop (Sclerotinia sclerotiorum). With increasing prevalence of pathogen resistance to fungicides and environmental concerns, there is an urgent need to identify sources of genetic resistance to B. cinerea and S. sclerotiorum in lettuce. We demonstrated genetic variation for quantitative resistance to B. cinerea and S. sclerotiorum in a set of 97 diverse lettuce and wild relative accessions, and between the parents of lettuce mapping populations. Transcriptome profiling across multiple lettuce accessions enabled us to identify genes with expression correlated with resistance, predicting the importance of post-transcriptional gene regulation in the lettuce defence response. We identified five genetic loci influencing quantitative resistance in a F6 mapping population derived from a Lactuca serriola (wild relative) × lettuce cross, which each explained 5–10% of the variation. Differential gene expression analysis between the parent lines, and integration of data on correlation of gene expression and resistance in the diversity set, highlighted potential causal genes underlying the quantitative trait loci. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Theoretical & Applied Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00122-022-04129-5
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        Text: English
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      – SubjectFull: Lettuce
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      – SubjectFull: Locus (Genetics)
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      – SubjectFull: Edible greens
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      – SubjectFull: Fungicide resistance
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