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Biocides used as material preservatives modify rates of de novo mutation and horizontal gene transfer in bacteria.

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Title: Biocides used as material preservatives modify rates of de novo mutation and horizontal gene transfer in bacteria.
Authors: Schmidt, Selina B.I.1 (AUTHOR) selinainocencia@gmail.com, Rodríguez-Rojas, Alexandro2,3 (AUTHOR) alexandro.rojas@vetmeduni.ac.at, Rolff, Jens2 (AUTHOR) jens.rolff@fu-berlin.de, Schreiber, Frank1 (AUTHOR) frank.schreiber@bam.de
Source: Journal of Hazardous Materials. Sep2022, Vol. 437, pN.PAG-N.PAG. 1p.
Subjects: Horizontal gene transfer, Bacterial transformation, Biocides, Insecticides, Paternal age effect, Chlorhexidine, Genetic mutation
Abstract: Antimicrobial resistance (AMR) is a global health problem with the environment being an important compartment for the evolution and transmission of AMR. Previous studies showed that de-novo mutagenesis and horizontal gene transfer (HGT) by conjugation or transformation – important processes underlying resistance evolution and spread - are affected by antibiotics, metals and pesticides. However, natural microbial communities are also frequently exposed to biocides used as material preservatives, but it is unknown if these substances induce mutagenesis and HGT. Here, we show that active substances used in material preservatives can increase rates of mutation and conjugation in a species- and substance-dependent manner, while rates of transformation are not increased. The bisbiguanide chlorhexidine digluconate, the quaternary ammonium compound didecyldimethylammonium chloride, the metal copper, the pyrethroid-insecticide permethrin, and the azole-fungicide propiconazole increase mutation rates in Escherichia coli, whereas no increases were identified for Bacillus subtilis and Acinetobacter baylyi. Benzalkonium chloride, chlorhexidine and permethrin increased conjugation in E. coli. Moreover, our results show a connection between the RpoS-mediated general stress and the RecA-linked SOS response with increased rates of mutation and conjugation, but not for all biocides. Taken together, our data show the importance of assessing the contribution of material preservatives on AMR evolution and spread. [Display omitted] • Chlorhexidine, DDAC, Cu, permethrin and propiconazole increase mutation rates in E. coli. • Chlorhexidine, benzalkonium chloride and permethrin increase conjugation in E. coli. • Biocides do not increase transformation in Acinetobacter baylyi. • Biocides induce rpoS (stress response) and recA (SOS response) in E. coli. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Hazardous Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 158116966
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
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  Data: Biocides used as material preservatives modify rates of de novo mutation and horizontal gene transfer in bacteria.
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  Data: <searchLink fieldCode="AR" term="%22Schmidt%2C+Selina+B%2EI%2E%22">Schmidt, Selina B.I.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> selinainocencia@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Rodríguez-Rojas%2C+Alexandro%22">Rodríguez-Rojas, Alexandro</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> alexandro.rojas@vetmeduni.ac.at</i><br /><searchLink fieldCode="AR" term="%22Rolff%2C+Jens%22">Rolff, Jens</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> jens.rolff@fu-berlin.de</i><br /><searchLink fieldCode="AR" term="%22Schreiber%2C+Frank%22">Schreiber, Frank</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> frank.schreiber@bam.de</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Hazardous+Materials%22">Journal of Hazardous Materials</searchLink>. Sep2022, Vol. 437, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Horizontal+gene+transfer%22">Horizontal gene transfer</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+transformation%22">Bacterial transformation</searchLink><br /><searchLink fieldCode="DE" term="%22Biocides%22">Biocides</searchLink><br /><searchLink fieldCode="DE" term="%22Insecticides%22">Insecticides</searchLink><br /><searchLink fieldCode="DE" term="%22Paternal+age+effect%22">Paternal age effect</searchLink><br /><searchLink fieldCode="DE" term="%22Chlorhexidine%22">Chlorhexidine</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Antimicrobial resistance (AMR) is a global health problem with the environment being an important compartment for the evolution and transmission of AMR. Previous studies showed that de-novo mutagenesis and horizontal gene transfer (HGT) by conjugation or transformation – important processes underlying resistance evolution and spread - are affected by antibiotics, metals and pesticides. However, natural microbial communities are also frequently exposed to biocides used as material preservatives, but it is unknown if these substances induce mutagenesis and HGT. Here, we show that active substances used in material preservatives can increase rates of mutation and conjugation in a species- and substance-dependent manner, while rates of transformation are not increased. The bisbiguanide chlorhexidine digluconate, the quaternary ammonium compound didecyldimethylammonium chloride, the metal copper, the pyrethroid-insecticide permethrin, and the azole-fungicide propiconazole increase mutation rates in Escherichia coli, whereas no increases were identified for Bacillus subtilis and Acinetobacter baylyi. Benzalkonium chloride, chlorhexidine and permethrin increased conjugation in E. coli. Moreover, our results show a connection between the RpoS-mediated general stress and the RecA-linked SOS response with increased rates of mutation and conjugation, but not for all biocides. Taken together, our data show the importance of assessing the contribution of material preservatives on AMR evolution and spread. [Display omitted] • Chlorhexidine, DDAC, Cu, permethrin and propiconazole increase mutation rates in E. coli. • Chlorhexidine, benzalkonium chloride and permethrin increase conjugation in E. coli. • Biocides do not increase transformation in Acinetobacter baylyi. • Biocides induce rpoS (stress response) and recA (SOS response) in E. coli. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Hazardous Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jhazmat.2022.129280
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Horizontal gene transfer
        Type: general
      – SubjectFull: Bacterial transformation
        Type: general
      – SubjectFull: Biocides
        Type: general
      – SubjectFull: Insecticides
        Type: general
      – SubjectFull: Paternal age effect
        Type: general
      – SubjectFull: Chlorhexidine
        Type: general
      – SubjectFull: Genetic mutation
        Type: general
    Titles:
      – TitleFull: Biocides used as material preservatives modify rates of de novo mutation and horizontal gene transfer in bacteria.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Schmidt, Selina B.I.
      – PersonEntity:
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            NameFull: Rodríguez-Rojas, Alexandro
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            NameFull: Rolff, Jens
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            NameFull: Schreiber, Frank
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            – D: 05
              M: 09
              Text: Sep2022
              Type: published
              Y: 2022
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            – Type: issn-print
              Value: 03043894
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            – Type: volume
              Value: 437
          Titles:
            – TitleFull: Journal of Hazardous Materials
              Type: main
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