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Characterization and correction of the effects of hepatic iron on T1ρ relaxation in the liver at 3.0T.

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Title: Characterization and correction of the effects of hepatic iron on T1ρ relaxation in the liver at 3.0T.
Authors: Qian, Yurui1 (AUTHOR), Hou, Jian1 (AUTHOR), Jiang, Baiyan1,2 (AUTHOR), Wong, Vincent Wai‐Sun3 (AUTHOR), Lee, Jack4,5 (AUTHOR), Chan, Queenie6 (AUTHOR), Wang, Yixiang1 (AUTHOR), Chu, Winnie Chiu‐Wing1 (AUTHOR), Chen, Weitian1 (AUTHOR) wtchen@cuhk.edu.hk
Source: Magnetic Resonance in Medicine. Oct2022, Vol. 88 Issue 4, p1828-1839. 12p.
Subjects: Liver, Iron, Calibration, Volunteers, Tissues
Abstract: Purpose: Quantitative T1ρ imaging is an emerging technique to assess the biochemical properties of tissues. In this paper, we report our observation that liver iron content (LIC) affects T1ρ quantification of the liver at 3.0T field strength and develop a method to correct the effect of LIC. Theory and Methods: On‐resonance R1ρ (1/T1ρ) is mainly affected by the intrinsic R2 (1/T2), which is influenced by LIC. As on‐resonance R1ρ is closely related to the Carr–Purcell–Meiboom–Gill (CPMG) R2, and because the calibration between CPMG R2 and LIC has been reported at 1.5T, a correction method was proposed to correct the R2 contribution to the R1ρ. The correction coefficient was obtained from the calibration results and related transformed factors. To compensate for the difference between CPMG R2 and R1ρ, a scaling factor was determined using the values of CPMG R2 and R1ρ, obtained simultaneously from a single breath‐hold from volunteers. The livers of 110 subjects were scanned to validate the correction method. Results: LIC was significantly correlated with R1ρ in the liver. However, when the proposed correction method was applied to R1ρ, LIC and the iron‐corrected R1ρ were not significantly correlated. Conclusion: LIC can affect T1ρ in the liver. We developed an iron‐correction method for the quantification of T1ρ in the liver at 3.0T. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Characterization and correction of the effects of hepatic iron on T<subscript>1ρ</subscript> relaxation in the liver at 3.0T.
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  Data: <searchLink fieldCode="AR" term="%22Qian%2C+Yurui%22">Qian, Yurui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hou%2C+Jian%22">Hou, Jian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Baiyan%22">Jiang, Baiyan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wong%2C+Vincent+Wai‐Sun%22">Wong, Vincent Wai‐Sun</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jack%22">Lee, Jack</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Queenie%22">Chan, Queenie</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yixiang%22">Wang, Yixiang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chu%2C+Winnie+Chiu‐Wing%22">Chu, Winnie Chiu‐Wing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Weitian%22">Chen, Weitian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wtchen@cuhk.edu.hk</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Oct2022, Vol. 88 Issue 4, p1828-1839. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Liver%22">Liver</searchLink><br /><searchLink fieldCode="DE" term="%22Iron%22">Iron</searchLink><br /><searchLink fieldCode="DE" term="%22Calibration%22">Calibration</searchLink><br /><searchLink fieldCode="DE" term="%22Volunteers%22">Volunteers</searchLink><br /><searchLink fieldCode="DE" term="%22Tissues%22">Tissues</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Quantitative T1ρ imaging is an emerging technique to assess the biochemical properties of tissues. In this paper, we report our observation that liver iron content (LIC) affects T1ρ quantification of the liver at 3.0T field strength and develop a method to correct the effect of LIC. Theory and Methods: On‐resonance R1ρ (1/T1ρ) is mainly affected by the intrinsic R2 (1/T2), which is influenced by LIC. As on‐resonance R1ρ is closely related to the Carr–Purcell–Meiboom–Gill (CPMG) R2, and because the calibration between CPMG R2 and LIC has been reported at 1.5T, a correction method was proposed to correct the R2 contribution to the R1ρ. The correction coefficient was obtained from the calibration results and related transformed factors. To compensate for the difference between CPMG R2 and R1ρ, a scaling factor was determined using the values of CPMG R2 and R1ρ, obtained simultaneously from a single breath‐hold from volunteers. The livers of 110 subjects were scanned to validate the correction method. Results: LIC was significantly correlated with R1ρ in the liver. However, when the proposed correction method was applied to R1ρ, LIC and the iron‐corrected R1ρ were not significantly correlated. Conclusion: LIC can affect T1ρ in the liver. We developed an iron‐correction method for the quantification of T1ρ in the liver at 3.0T. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1002/mrm.29310
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 1828
    Subjects:
      – SubjectFull: Liver
        Type: general
      – SubjectFull: Iron
        Type: general
      – SubjectFull: Calibration
        Type: general
      – SubjectFull: Volunteers
        Type: general
      – SubjectFull: Tissues
        Type: general
    Titles:
      – TitleFull: Characterization and correction of the effects of hepatic iron on T1ρ relaxation in the liver at 3.0T.
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            NameFull: Qian, Yurui
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            NameFull: Hou, Jian
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            NameFull: Wong, Vincent Wai‐Sun
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            – D: 01
              M: 10
              Text: Oct2022
              Type: published
              Y: 2022
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              Value: 88
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