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Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity‐induced coronary microvascular disease.

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Title: Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity‐induced coronary microvascular disease.
Authors: Shah, Soham A.1 (AUTHOR), Echols, John T.1 (AUTHOR), Sun, Changyu1,2,3 (AUTHOR), Wolf, Matthew J.4 (AUTHOR), Epstein, Frederick H.1,5 (AUTHOR) fhe6b@virginia.edu
Source: Magnetic Resonance in Medicine. Oct2022, Vol. 88 Issue 4, p1734-1747. 14p.
Subjects: Adipose tissues, Coronary disease, Fatty acids, Saturated fatty acids, Laboratory mice, Mucocutaneous lymph node syndrome
Abstract: Purpose: To develop an accelerated MRI method to quantify the epicardial adipose tissue (EAT) fatty acid composition (FAC) and test the hypothesis that eplerenone (EPL) shifts the EAT FAC toward unsaturation in obese mice. Methods: Undersampled multi‐echo gradient echo imaging employing a dictionary‐based compressed‐sensing reconstruction and iterative decomposition with echo asymmetry and least‐squares–based mapping (IDEAL) was developed, validated, and used to study EAT in obese mice scanned at 7T. Fully sampled and rate 2, 2.5, 3, and 3.5 undersampled image data were acquired, reconstructed, and assessed using RMSE and structural similarity (SSIM). Two groups of mice were studied: untreated (control, n = 10) and EPL‐treated (n = 10) mice fed a high‐fat high‐sucrose diet. MRI included imaging of EAT FAC, EAT volume, and myocardial perfusion reserve. Results: Rate 3 acceleration provided RMSE <5% and structural similarity >0.85 for FAC MRI. After 6 weeks of diet, EPL‐treated compared to untreated mice had a reduced EAT saturated fatty acid fraction (0.27 ± 0.09 vs. 0.39 ± 0.07, P < 0.05) and increased EAT unsaturation degree (4.37 ± 0.32 vs. 3.69 ± 0.58, P < 0.05). Also, EAT volume in EPL‐treated compared to untreated mice was reduced (8.1 ± 0.6 mg vs. 11.4 ± 0.7 mg, P < 0.01), and myocardial perfusion reserve was improved (1.83 ± 0.15 vs. 1.61 ± 0.17, P < 0.05). Conclusion: Rate 3 accelerated FAC MRI enabled accurate quantification of EAT FAC in mice. EPL treatment shifted the EAT FAC toward increased unsaturation and was associated with improvement of coronary microvascular function. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity‐induced coronary microvascular disease.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shah%2C+Soham+A%2E%22&quot;&gt;Shah, Soham A.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Echols%2C+John+T%2E%22&quot;&gt;Echols, John T.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sun%2C+Changyu%22&quot;&gt;Sun, Changyu&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wolf%2C+Matthew+J%2E%22&quot;&gt;Wolf, Matthew J.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Epstein%2C+Frederick+H%2E%22&quot;&gt;Epstein, Frederick H.&lt;/searchLink&gt;&lt;relatesTo&gt;1,5&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; fhe6b@virginia.edu&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Oct2022, Vol. 88 Issue 4, p1734-1747. 14p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adipose+tissues%22&quot;&gt;Adipose tissues&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coronary+disease%22&quot;&gt;Coronary disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fatty+acids%22&quot;&gt;Fatty acids&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Saturated+fatty+acids%22&quot;&gt;Saturated fatty acids&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Laboratory+mice%22&quot;&gt;Laboratory mice&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mucocutaneous+lymph+node+syndrome%22&quot;&gt;Mucocutaneous lymph node syndrome&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To develop an accelerated MRI method to quantify the epicardial adipose tissue (EAT) fatty acid composition (FAC) and test the hypothesis that eplerenone (EPL) shifts the EAT FAC toward unsaturation in obese mice. Methods: Undersampled multi‐echo gradient echo imaging employing a dictionary‐based compressed‐sensing reconstruction and iterative decomposition with echo asymmetry and least‐squares–based mapping (IDEAL) was developed, validated, and used to study EAT in obese mice scanned at 7T. Fully sampled and rate 2, 2.5, 3, and 3.5 undersampled image data were acquired, reconstructed, and assessed using RMSE and structural similarity (SSIM). Two groups of mice were studied: untreated (control, n = 10) and EPL‐treated (n = 10) mice fed a high‐fat high‐sucrose diet. MRI included imaging of EAT FAC, EAT volume, and myocardial perfusion reserve. Results: Rate 3 acceleration provided RMSE &lt;5% and structural similarity &gt;0.85 for FAC MRI. After 6 weeks of diet, EPL‐treated compared to untreated mice had a reduced EAT saturated fatty acid fraction (0.27 &#177; 0.09 vs. 0.39 &#177; 0.07, P &lt; 0.05) and increased EAT unsaturation degree (4.37 &#177; 0.32 vs. 3.69 &#177; 0.58, P &lt; 0.05). Also, EAT volume in EPL‐treated compared to untreated mice was reduced (8.1 &#177; 0.6 mg vs. 11.4 &#177; 0.7 mg, P &lt; 0.01), and myocardial perfusion reserve was improved (1.83 &#177; 0.15 vs. 1.61 &#177; 0.17, P &lt; 0.05). Conclusion: Rate 3 accelerated FAC MRI enabled accurate quantification of EAT FAC in mice. EPL treatment shifted the EAT FAC toward increased unsaturation and was associated with improvement of coronary microvascular function. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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    Identifiers:
      – Type: doi
        Value: 10.1002/mrm.29348
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 1734
    Subjects:
      – SubjectFull: Adipose tissues
        Type: general
      – SubjectFull: Coronary disease
        Type: general
      – SubjectFull: Fatty acids
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      – SubjectFull: Saturated fatty acids
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      – SubjectFull: Laboratory mice
        Type: general
      – SubjectFull: Mucocutaneous lymph node syndrome
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      – TitleFull: Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity‐induced coronary microvascular disease.
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              Text: Oct2022
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              Y: 2022
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