A novel non-toxic camptothecin formulation for cancer chemotherapy
Saved in:
| Title: | A novel non-toxic camptothecin formulation for cancer chemotherapy |
|---|---|
| Authors: | Berrada, M.1, Serreqi, A.1, Dabbarh, F1, Owusu, A.2, Gupta, A.1, Lehnert, S.2 shirley.lehnert@mcgill.ca |
| Source: | Biomaterials. May2005, Vol. 26 Issue 14, p2115-2120. 6p. |
| Subjects: | Cancer treatment, Antineoplastic agents, Antiviral agents, Alkaloids |
| Abstract: | The use of a novel injectable biocompatible and biodegradable camptothecin-polymer implant for sustained intra-tumoral release of high concentrations of camptothecin is described. The drug delivery vehicle is an in situ thermogelling formulation, which is based on the natural biopolymer chitosan. This formulation, containing homogeneously dispersed camptothecin, was implanted intra-tumorally into a sub-cutaneous mouse tumor model (RIF-l). The effectiveness of treatment was measured in terms of tumor growth delay (TGD). Animals treated with the polymer implants containing camptothecin had significantly longer TGDs compared to untreated animals as well as to animals treated systemically with camptothecin by intra-peritoneal injection with no evidence of toxicity in terms of loss of body weight. The results indicate that this novel biodegradable polymer implant is an effective vehicle for the sustained intra-tumoral delivery of camptothecin which might also be suitable to deliver other insoluble anti-cancer drugs such as taxol. [Copyright &y& Elsevier] |
| Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 15825969 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: A novel non-toxic camptothecin formulation for cancer chemotherapy – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Berrada%2C+M%2E%22">Berrada, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Serreqi%2C+A%2E%22">Serreqi, A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dabbarh%2C+F%22">Dabbarh, F</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Owusu%2C+A%2E%22">Owusu, A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gupta%2C+A%2E%22">Gupta, A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lehnert%2C+S%2E%22">Lehnert, S.</searchLink><relatesTo>2</relatesTo><i> shirley.lehnert@mcgill.ca</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. May2005, Vol. 26 Issue 14, p2115-2120. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Antiviral+agents%22">Antiviral agents</searchLink><br /><searchLink fieldCode="DE" term="%22Alkaloids%22">Alkaloids</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The use of a novel injectable biocompatible and biodegradable camptothecin-polymer implant for sustained intra-tumoral release of high concentrations of camptothecin is described. The drug delivery vehicle is an in situ thermogelling formulation, which is based on the natural biopolymer chitosan. This formulation, containing homogeneously dispersed camptothecin, was implanted intra-tumorally into a sub-cutaneous mouse tumor model (RIF-l). The effectiveness of treatment was measured in terms of tumor growth delay (TGD). Animals treated with the polymer implants containing camptothecin had significantly longer TGDs compared to untreated animals as well as to animals treated systemically with camptothecin by intra-peritoneal injection with no evidence of toxicity in terms of loss of body weight. The results indicate that this novel biodegradable polymer implant is an effective vehicle for the sustained intra-tumoral delivery of camptothecin which might also be suitable to deliver other insoluble anti-cancer drugs such as taxol. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=15825969 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biomaterials.2004.06.013 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 2115 Subjects: – SubjectFull: Cancer treatment Type: general – SubjectFull: Antineoplastic agents Type: general – SubjectFull: Antiviral agents Type: general – SubjectFull: Alkaloids Type: general Titles: – TitleFull: A novel non-toxic camptothecin formulation for cancer chemotherapy Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Berrada, M. – PersonEntity: Name: NameFull: Serreqi, A. – PersonEntity: Name: NameFull: Dabbarh, F – PersonEntity: Name: NameFull: Owusu, A. – PersonEntity: Name: NameFull: Gupta, A. – PersonEntity: Name: NameFull: Lehnert, S. IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 05 Text: May2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 01429612 Numbering: – Type: volume Value: 26 – Type: issue Value: 14 Titles: – TitleFull: Biomaterials Type: main |
| ResultId | 1 |
