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Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging.

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Title: Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging.
Authors: Ding, Zi-You1 (AUTHOR), Xing, Qing-Guo1 (AUTHOR), Fan, Yi-Ran1 (AUTHOR), Song, Qi-Fa1 (AUTHOR), Song, Chun-Hui1 (AUTHOR), Han, Yingchao1,2 (AUTHOR) hanyingchao@whut.edu.cn
Source: Materials & Design. Sep2022, Vol. 221, pN.PAG-N.PAG. 1p.
Subjects: Calcium phosphate, Polyacrylic acid, Lungs, Reticulo-endothelial system, Inductive effect, Permeability
Abstract: [Display omitted] • Sub-10 nm and monodisperse Eu:CaP nanodot is biomimetically mineralized. • Surface effect and crystal field effect synergistically promote Eu3+ fluorescence. • Such nanodot, as bioimaging agent, has high biosafety with LD50 of 636.63 mg kg−1. • Ultrasmall size enhances tumor accumulation, permeability and renal clearance. Nano calcium phosphate (nCaP), a bone mineral in mammals, shows a promising prospect in biomedicine. Herein, we report a biomimetic mineralization strategy, based on stoichiometric polyacrylic acid (PAA) complexation-precipitation process, to facilitate the development of nCaP as bioimaging agents. As a result, the monodisperse and sub-10 nm europium-doped calcium phosphate nanodots (PAA-Eu:CaP NDs) is controllably obtained with enhanced fluorescence properties, tumor passive targeting and bioimaging ability. Compared with europium-doped calcium phosphate nanoparticles (Eu:CaP NPs), the fluorescence emission, quantum yield and lifetime of PAA-Eu:CaP NDs are significantly improved up to 3.84, 4.48 and 5.59 times, respectively. Deriving from the synergy of surface effect and organic/inorganic hybrid crystal field effect, such CaP matrix brings to local asymmetry environment and distinguished anti-quenching for Eu3+ ion. The strongest radiance signal is improved to 117 % for in vivo imaging; moreover, the tumor accumulation is obviously increased to 5.15 times, and 7.09 times for tumor permeability. The accumulation is decreased 80.2 %, 79.4 % and 70.2 % in liver, spleen and lung suggesting lower clearance by mononuclear phagocyte system, while it's increased up to 15.4 times in kidney indicating higher renal clearance. Eventually, it's convinced that this study can provide help for promoting CaP application in nanomedicine. [ABSTRACT FROM AUTHOR]
Copyright of Materials & Design is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 158674251
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  Label: Title
  Group: Ti
  Data: Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging.
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  Data: <searchLink fieldCode="AR" term="%22Ding%2C+Zi-You%22">Ding, Zi-You</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xing%2C+Qing-Guo%22">Xing, Qing-Guo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan%2C+Yi-Ran%22">Fan, Yi-Ran</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Qi-Fa%22">Song, Qi-Fa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Chun-Hui%22">Song, Chun-Hui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Yingchao%22">Han, Yingchao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> hanyingchao@whut.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Materials+%26+Design%22">Materials & Design</searchLink>. Sep2022, Vol. 221, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Polyacrylic+acid%22">Polyacrylic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Reticulo-endothelial+system%22">Reticulo-endothelial system</searchLink><br /><searchLink fieldCode="DE" term="%22Inductive+effect%22">Inductive effect</searchLink><br /><searchLink fieldCode="DE" term="%22Permeability%22">Permeability</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: [Display omitted] • Sub-10 nm and monodisperse Eu:CaP nanodot is biomimetically mineralized. • Surface effect and crystal field effect synergistically promote Eu3+ fluorescence. • Such nanodot, as bioimaging agent, has high biosafety with LD50 of 636.63 mg kg−1. • Ultrasmall size enhances tumor accumulation, permeability and renal clearance. Nano calcium phosphate (nCaP), a bone mineral in mammals, shows a promising prospect in biomedicine. Herein, we report a biomimetic mineralization strategy, based on stoichiometric polyacrylic acid (PAA) complexation-precipitation process, to facilitate the development of nCaP as bioimaging agents. As a result, the monodisperse and sub-10 nm europium-doped calcium phosphate nanodots (PAA-Eu:CaP NDs) is controllably obtained with enhanced fluorescence properties, tumor passive targeting and bioimaging ability. Compared with europium-doped calcium phosphate nanoparticles (Eu:CaP NPs), the fluorescence emission, quantum yield and lifetime of PAA-Eu:CaP NDs are significantly improved up to 3.84, 4.48 and 5.59 times, respectively. Deriving from the synergy of surface effect and organic/inorganic hybrid crystal field effect, such CaP matrix brings to local asymmetry environment and distinguished anti-quenching for Eu3+ ion. The strongest radiance signal is improved to 117 % for in vivo imaging; moreover, the tumor accumulation is obviously increased to 5.15 times, and 7.09 times for tumor permeability. The accumulation is decreased 80.2 %, 79.4 % and 70.2 % in liver, spleen and lung suggesting lower clearance by mononuclear phagocyte system, while it's increased up to 15.4 times in kidney indicating higher renal clearance. Eventually, it's convinced that this study can provide help for promoting CaP application in nanomedicine. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials & Design is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.matdes.2022.111008
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Calcium phosphate
        Type: general
      – SubjectFull: Polyacrylic acid
        Type: general
      – SubjectFull: Lungs
        Type: general
      – SubjectFull: Reticulo-endothelial system
        Type: general
      – SubjectFull: Inductive effect
        Type: general
      – SubjectFull: Permeability
        Type: general
    Titles:
      – TitleFull: Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging.
        Type: main
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          Name:
            NameFull: Ding, Zi-You
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            NameFull: Xing, Qing-Guo
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            NameFull: Fan, Yi-Ran
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            NameFull: Song, Qi-Fa
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            NameFull: Song, Chun-Hui
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            NameFull: Han, Yingchao
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          Dates:
            – D: 01
              M: 09
              Text: Sep2022
              Type: published
              Y: 2022
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              Value: 02641275
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              Value: 221
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            – TitleFull: Materials & Design
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