Contrast-enhanced ultrasound of solid pancreatic head lesions: a prospective study.
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| Title: | Contrast-enhanced ultrasound of solid pancreatic head lesions: a prospective study. |
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| Authors: | Gupta, Pankaj1 Pankajgupta959@gmail.com, Rana, Pratyaksha1, Marodia, Yashi1, Samanta, Jayanta2, Sharma, Vishal2, Sinha, Saroj K.2, Singh, Harjeet3, Gupta, Vikas3, Yadav, Thakur Deen3, Sreenivasan, Radhika4, Vaiphei, Kim5, Rajwanshi, Arvind4, Kochhar, Rakesh2, Sandhu, Manavjit1 |
| Source: | European Radiology. Oct2022, Vol. 32 Issue 10, p6668-6677. 10p. 4 Color Photographs, 1 Diagram, 5 Charts. |
| Abstract: | Objective: To evaluate the role of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of solid pancreatic head lesions (SPHL). Methods: This prospective study comprised consecutive patients with SPHL who underwent CEUS evaluation of the pancreas. Findings recorded at CEUS were enhancement patterns (degree, completeness, centripetal enhancement, and percentage enhancement) and presence of central vessels. In addition, time to peak (TTP) and washout time (WT) were recorded. The final diagnosis was based on histopathology or cytology. Multivariate analysis was performed to identify parameters that were significantly associated with pancreatic ductal adenocarcinoma (PDAC). Results: Ninety-eight patients (median age 53.8 years, 59 males) were evaluated. The final diagnosis was PDAC (n = 64, 65.3%), inflammatory mass (n = 16, 16.3%), neuroendocrine tumor (NET, n = 14, 14.3%), and other tumors (n = 4, 4.1%). Hypoenhancement, incomplete enhancement, and centripetal enhancement were significantly more common in PDAC than non-PDAC lesions (p = 0.001, p = 0.031, and p = 0.002, respectively). Central vessels were present in a significantly greater number of non-PDAC lesions (p = 0.0001). Hypoenhancement with < 30% enhancement at CEUS had sensitivity and specificity of 80.6% and 67.7%, respectively, for PDAC. There was no significant difference in the TTP and WT between PDAC and non - PDAC lesions. However, the WT was significantly shorter in PDAC compared to NET (p = 0.011). In multivariate analysis, lack of central vessels was significantly associated with a PDAC diagnosis. Conclusion: CEUS is a useful tool for the evaluation of SPHL. CEUS can be incorporated into the diagnostic algorithm to differentiate PDAC from non-PDAC lesions. Key Points: • Hypoenhancement and incomplete enhancement at CEUS were significantly more common in PDAC than in non-PDAC. • Central vessels at CEUS were significantly associated with PDAC. • There was no difference in TTP and WT between PDAC and non-PDAC lesions. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 159103973 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Contrast-enhanced ultrasound of solid pancreatic head lesions: a prospective study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gupta%2C+Pankaj%22">Gupta, Pankaj</searchLink><relatesTo>1</relatesTo><i> Pankajgupta959@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Rana%2C+Pratyaksha%22">Rana, Pratyaksha</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Marodia%2C+Yashi%22">Marodia, Yashi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Samanta%2C+Jayanta%22">Samanta, Jayanta</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sharma%2C+Vishal%22">Sharma, Vishal</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sinha%2C+Saroj+K%2E%22">Sinha, Saroj K.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Singh%2C+Harjeet%22">Singh, Harjeet</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Gupta%2C+Vikas%22">Gupta, Vikas</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yadav%2C+Thakur+Deen%22">Yadav, Thakur Deen</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sreenivasan%2C+Radhika%22">Sreenivasan, Radhika</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Vaiphei%2C+Kim%22">Vaiphei, Kim</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Rajwanshi%2C+Arvind%22">Rajwanshi, Arvind</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Kochhar%2C+Rakesh%22">Kochhar, Rakesh</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sandhu%2C+Manavjit%22">Sandhu, Manavjit</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Oct2022, Vol. 32 Issue 10, p6668-6677. 10p. 4 Color Photographs, 1 Diagram, 5 Charts. – Name: Abstract Label: Abstract Group: Ab Data: Objective: To evaluate the role of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of solid pancreatic head lesions (SPHL). Methods: This prospective study comprised consecutive patients with SPHL who underwent CEUS evaluation of the pancreas. Findings recorded at CEUS were enhancement patterns (degree, completeness, centripetal enhancement, and percentage enhancement) and presence of central vessels. In addition, time to peak (TTP) and washout time (WT) were recorded. The final diagnosis was based on histopathology or cytology. Multivariate analysis was performed to identify parameters that were significantly associated with pancreatic ductal adenocarcinoma (PDAC). Results: Ninety-eight patients (median age 53.8 years, 59 males) were evaluated. The final diagnosis was PDAC (n = 64, 65.3%), inflammatory mass (n = 16, 16.3%), neuroendocrine tumor (NET, n = 14, 14.3%), and other tumors (n = 4, 4.1%). Hypoenhancement, incomplete enhancement, and centripetal enhancement were significantly more common in PDAC than non-PDAC lesions (p = 0.001, p = 0.031, and p = 0.002, respectively). Central vessels were present in a significantly greater number of non-PDAC lesions (p = 0.0001). Hypoenhancement with < 30% enhancement at CEUS had sensitivity and specificity of 80.6% and 67.7%, respectively, for PDAC. There was no significant difference in the TTP and WT between PDAC and non - PDAC lesions. However, the WT was significantly shorter in PDAC compared to NET (p = 0.011). In multivariate analysis, lack of central vessels was significantly associated with a PDAC diagnosis. Conclusion: CEUS is a useful tool for the evaluation of SPHL. CEUS can be incorporated into the diagnostic algorithm to differentiate PDAC from non-PDAC lesions. Key Points: • Hypoenhancement and incomplete enhancement at CEUS were significantly more common in PDAC than in non-PDAC. • Central vessels at CEUS were significantly associated with PDAC. • There was no difference in TTP and WT between PDAC and non-PDAC lesions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-022-08854-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 6668 Titles: – TitleFull: Contrast-enhanced ultrasound of solid pancreatic head lesions: a prospective study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gupta, Pankaj – PersonEntity: Name: NameFull: Rana, Pratyaksha – PersonEntity: Name: NameFull: Marodia, Yashi – PersonEntity: Name: NameFull: Samanta, Jayanta – PersonEntity: Name: NameFull: Sharma, Vishal – PersonEntity: Name: NameFull: Sinha, Saroj K. – PersonEntity: Name: NameFull: Singh, Harjeet – PersonEntity: Name: NameFull: Gupta, Vikas – PersonEntity: Name: NameFull: Yadav, Thakur Deen – PersonEntity: Name: NameFull: Sreenivasan, Radhika – PersonEntity: Name: NameFull: Vaiphei, Kim – PersonEntity: Name: NameFull: Rajwanshi, Arvind – PersonEntity: Name: NameFull: Kochhar, Rakesh – PersonEntity: Name: NameFull: Sandhu, Manavjit IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 32 – Type: issue Value: 10 Titles: – TitleFull: European Radiology Type: main |
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