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Lamellar orientation in human cornea in relation to mechanical properties

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Title: Lamellar orientation in human cornea in relation to mechanical properties
Authors: Boote, Craig1 bootec@cf.ac.uk, Dennis, Sally1, Huang, Yifei2, Quantock, Andrew J.1, Meek, Keith M.1
Source: Journal of Structural Biology. Jan2005, Vol. 149 Issue 1, p1-6. 6p.
Subjects: Cornea, Connective tissues, Extracellular matrix proteins, Collagen
Abstract: Abstract: We have applied wide-angle X-ray scattering to the human cornea in order to quantify the relative number of stromal collagen fibrils directed along the two preferred corneal lamellar directions: superior–inferior and nasal–temporal. The data suggest that, on average, the two directions are populated in equal proportion at the corneal centre. Here, approximately one-third of the fibrils throughout the stromal depth tend to lie within a 45° sector of the superior–inferior meridian, and similarly for the nasal–temporal direction. However, in some eyes we have measured significant differences between the two preferential fibril populations, with some corneas exhibiting as much as 25% more collagen in one direction than the other. Based on these findings, a mechanical model of the normal cornea may be envisaged, whereby the fibril tension in the underlying “background” of isotropically arranged collagen helps to balance the intraocular pressure; while the extra preferentially aligned fibrils take up the additional tensile stress along the superior–inferior and nasal–temporal meridians exerted by the rectus muscles and the orbicularis. It is possible that, through a direct impact on the elastic modulus of the tissue, an imbalance of superior–inferior and nasal–temporal fibrils in some eyes might affect corneal shape. [Copyright &y& Elsevier]
Copyright of Journal of Structural Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: <searchLink fieldCode="DE" term="%22Cornea%22">Cornea</searchLink><br /><searchLink fieldCode="DE" term="%22Connective+tissues%22">Connective tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix+proteins%22">Extracellular matrix proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Collagen%22">Collagen</searchLink>
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  Data: Abstract: We have applied wide-angle X-ray scattering to the human cornea in order to quantify the relative number of stromal collagen fibrils directed along the two preferred corneal lamellar directions: superior–inferior and nasal–temporal. The data suggest that, on average, the two directions are populated in equal proportion at the corneal centre. Here, approximately one-third of the fibrils throughout the stromal depth tend to lie within a 45° sector of the superior–inferior meridian, and similarly for the nasal–temporal direction. However, in some eyes we have measured significant differences between the two preferential fibril populations, with some corneas exhibiting as much as 25% more collagen in one direction than the other. Based on these findings, a mechanical model of the normal cornea may be envisaged, whereby the fibril tension in the underlying “background” of isotropically arranged collagen helps to balance the intraocular pressure; while the extra preferentially aligned fibrils take up the additional tensile stress along the superior–inferior and nasal–temporal meridians exerted by the rectus muscles and the orbicularis. It is possible that, through a direct impact on the elastic modulus of the tissue, an imbalance of superior–inferior and nasal–temporal fibrils in some eyes might affect corneal shape. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Journal of Structural Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.jsb.2004.08.009
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Connective tissues
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      – SubjectFull: Extracellular matrix proteins
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      – SubjectFull: Collagen
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              Text: Jan2005
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