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Infection‐competent monkeypox virus contamination identified in domestic settings following an imported case of monkeypox into the UK.

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Title: Infection‐competent monkeypox virus contamination identified in domestic settings following an imported case of monkeypox into the UK.
Authors: Atkinson, Barry1 (AUTHOR) barry.atkinson@ukhsa.gov.uk, Burton, Christopher2 (AUTHOR), Pottage, Thomas1 (AUTHOR), Thompson, Katy‐Anne1 (AUTHOR), Ngabo, Didier1 (AUTHOR), Crook, Ant1 (AUTHOR), Pitman, James2 (AUTHOR), Summers, Sian2 (AUTHOR), Lewandowski, Kuiama1 (AUTHOR), Furneaux, Jenna3 (AUTHOR), Davies, Katherine1 (AUTHOR), Brooks, Timothy3,4 (AUTHOR), Bennett, Allan M.1 (AUTHOR), Richards, Kevin S.2,5 (AUTHOR)
Source: Environmental Microbiology. Oct2022, Vol. 24 Issue 10, p4561-4569. 9p.
Subjects: Monkeypox, Reverse transcriptase, Environmental sampling, DNA viruses, COVID-19, Sampling (Process), Reverse transcriptase polymerase chain reaction
Geographic Terms: Nigeria, United Kingdom
Abstract: An imported case of monkeypox was diagnosed in December 2019 in a traveller returning from Nigeria to the UK. Subsequently, environmental sampling was performed at two adjoining single‐room residences occupied by the patient and their sibling. Monkeypox virus DNA was identified in multiple locations throughout both properties, and monkeypox virus was isolated from several samples 3 days after the patient was last in these locations. Positive samples were identified following the use of both vacuum and surface sampling techniques; these methodologies allowed for environmental analysis of potentially contaminated porous and non‐porous surfaces via real‐time quantitative reverse transcriptase PCR analysis in addition to viral isolation to confirm the presence of infection‐competent virus. This report confirms the potential for infection‐competent monkeypox virus to be recovered in environmental settings associated with known positive cases and the necessity for rapid environmental assessment to reduce potential exposure to close contacts and the general public. The methods adopted in this investigation may be used for future confirmed cases of monkeypox in order to establish levels of contamination, confirm the presence of infection‐competent material and to identify locations requiring additional cleaning. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: Infection‐competent monkeypox virus contamination identified in domestic settings following an imported case of monkeypox into the UK.
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  Data: <searchLink fieldCode="AR" term="%22Atkinson%2C+Barry%22">Atkinson, Barry</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> barry.atkinson@ukhsa.gov.uk</i><br /><searchLink fieldCode="AR" term="%22Burton%2C+Christopher%22">Burton, Christopher</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pottage%2C+Thomas%22">Pottage, Thomas</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thompson%2C+Katy‐Anne%22">Thompson, Katy‐Anne</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ngabo%2C+Didier%22">Ngabo, Didier</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crook%2C+Ant%22">Crook, Ant</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pitman%2C+James%22">Pitman, James</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Summers%2C+Sian%22">Summers, Sian</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewandowski%2C+Kuiama%22">Lewandowski, Kuiama</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Furneaux%2C+Jenna%22">Furneaux, Jenna</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davies%2C+Katherine%22">Davies, Katherine</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brooks%2C+Timothy%22">Brooks, Timothy</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bennett%2C+Allan+M%2E%22">Bennett, Allan M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Richards%2C+Kevin+S%2E%22">Richards, Kevin S.</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Microbiology%22">Environmental Microbiology</searchLink>. Oct2022, Vol. 24 Issue 10, p4561-4569. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Monkeypox%22">Monkeypox</searchLink><br /><searchLink fieldCode="DE" term="%22Reverse+transcriptase%22">Reverse transcriptase</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+sampling%22">Environmental sampling</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+viruses%22">DNA viruses</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Sampling+%28Process%29%22">Sampling (Process)</searchLink><br /><searchLink fieldCode="DE" term="%22Reverse+transcriptase+polymerase+chain+reaction%22">Reverse transcriptase polymerase chain reaction</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Nigeria%22">Nigeria</searchLink><br /><searchLink fieldCode="DE" term="%22United+Kingdom%22">United Kingdom</searchLink>
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  Label: Abstract
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  Data: An imported case of monkeypox was diagnosed in December 2019 in a traveller returning from Nigeria to the UK. Subsequently, environmental sampling was performed at two adjoining single‐room residences occupied by the patient and their sibling. Monkeypox virus DNA was identified in multiple locations throughout both properties, and monkeypox virus was isolated from several samples 3 days after the patient was last in these locations. Positive samples were identified following the use of both vacuum and surface sampling techniques; these methodologies allowed for environmental analysis of potentially contaminated porous and non‐porous surfaces via real‐time quantitative reverse transcriptase PCR analysis in addition to viral isolation to confirm the presence of infection‐competent virus. This report confirms the potential for infection‐competent monkeypox virus to be recovered in environmental settings associated with known positive cases and the necessity for rapid environmental assessment to reduce potential exposure to close contacts and the general public. The methods adopted in this investigation may be used for future confirmed cases of monkeypox in order to establish levels of contamination, confirm the presence of infection‐competent material and to identify locations requiring additional cleaning. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environmental Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/1462-2920.16129
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 4561
    Subjects:
      – SubjectFull: Monkeypox
        Type: general
      – SubjectFull: Reverse transcriptase
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      – SubjectFull: Environmental sampling
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      – SubjectFull: DNA viruses
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      – SubjectFull: COVID-19
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      – SubjectFull: Sampling (Process)
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      – SubjectFull: Reverse transcriptase polymerase chain reaction
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      – SubjectFull: Nigeria
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      – SubjectFull: United Kingdom
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              M: 10
              Text: Oct2022
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