View in EDS

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.

Saved in:
Bibliographic Details
Title: Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.
Authors: Pauwels, Marie J.1,2 (AUTHOR), Xie, Junhua1,2 (AUTHOR), Ceroi, Adam1,2 (AUTHOR), Balusu, Sriram3 (AUTHOR), Castelein, Jonas1,2 (AUTHOR), Van Wonterghem, Elien1,2 (AUTHOR), Van Imschoot, Griet1,2 (AUTHOR), Ward, Andrew4 (AUTHOR), Menheniott, Trevelyan R.5,6 (AUTHOR), Gustafsson, Oskar7 (AUTHOR), Combes, Francis8 (AUTHOR), EL Andaloussi, Samir7 (AUTHOR), Sanders, Niek N.9,10 (AUTHOR), Mäger, Imre11,12 (AUTHOR), Van Hoecke, Lien1,2 (AUTHOR), Vandenbroucke, Roosmarijn E.1,2 (AUTHOR) roosmarijn.vandenbroucke@irc.vib-ugent.be
Source: Biomaterials. Nov2022, Vol. 290, pN.PAG-N.PAG. 1p.
Subjects: Extracellular vesicles, Blood-brain barrier, Drug delivery systems, Choroid plexus, Choroid, Central nervous system
Abstract: The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most research focuses on the blood-brain barrier (BBB), the design of drug delivery platforms that are able to cross the blood-cerebrospinal fluid (CSF) barrier, formed by a single layer of choroid plexus epithelial cells, remains a largely unexplored domain. The discovery that extracellular vesicles (EVs) make up a natural mechanism for information transfer between cells and across cell layers, has stimulated interest in their potential use as drug delivery platform. Here, we report that choroid plexus epithelial cell-derived EVs exhibit the capacity to home to the brain after peripheral administration. Moreover, these vesicles are able to functionally deliver cargo into the brain. Our findings underline the therapeutic potential of choroid plexus-derived EVs as a brain drug delivery vehicle via targeting of the blood-CSF interface. [Display omitted] • The blood-cerebrospinal fluid barrier, located at the choroid plexus, is a largely unexplored brain barrier in drug delivery. • Extracellular vesicles hold great potential as drug delivery vehicle. • Choroid plexus epithelial cell-derived extracellular vesicles home to the brain and choroid plexus. • Choroid plexus epithelial cell-derived extracellular vesicles functionally deliver cargo to astrocytes and microglia. [ABSTRACT FROM AUTHOR]
Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 159928484
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Pauwels%2C+Marie+J%2E%22">Pauwels, Marie J.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Junhua%22">Xie, Junhua</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ceroi%2C+Adam%22">Ceroi, Adam</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balusu%2C+Sriram%22">Balusu, Sriram</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Castelein%2C+Jonas%22">Castelein, Jonas</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Wonterghem%2C+Elien%22">Van Wonterghem, Elien</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Imschoot%2C+Griet%22">Van Imschoot, Griet</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ward%2C+Andrew%22">Ward, Andrew</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Menheniott%2C+Trevelyan+R%2E%22">Menheniott, Trevelyan R.</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gustafsson%2C+Oskar%22">Gustafsson, Oskar</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Combes%2C+Francis%22">Combes, Francis</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22EL+Andaloussi%2C+Samir%22">EL Andaloussi, Samir</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sanders%2C+Niek+N%2E%22">Sanders, Niek N.</searchLink><relatesTo>9,10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mäger%2C+Imre%22">Mäger, Imre</searchLink><relatesTo>11,12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Hoecke%2C+Lien%22">Van Hoecke, Lien</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vandenbroucke%2C+Roosmarijn+E%2E%22">Vandenbroucke, Roosmarijn E.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> roosmarijn.vandenbroucke@irc.vib-ugent.be</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Nov2022, Vol. 290, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Extracellular+vesicles%22">Extracellular vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22Blood-brain+barrier%22">Blood-brain barrier</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Choroid+plexus%22">Choroid plexus</searchLink><br /><searchLink fieldCode="DE" term="%22Choroid%22">Choroid</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most research focuses on the blood-brain barrier (BBB), the design of drug delivery platforms that are able to cross the blood-cerebrospinal fluid (CSF) barrier, formed by a single layer of choroid plexus epithelial cells, remains a largely unexplored domain. The discovery that extracellular vesicles (EVs) make up a natural mechanism for information transfer between cells and across cell layers, has stimulated interest in their potential use as drug delivery platform. Here, we report that choroid plexus epithelial cell-derived EVs exhibit the capacity to home to the brain after peripheral administration. Moreover, these vesicles are able to functionally deliver cargo into the brain. Our findings underline the therapeutic potential of choroid plexus-derived EVs as a brain drug delivery vehicle via targeting of the blood-CSF interface. [Display omitted] • The blood-cerebrospinal fluid barrier, located at the choroid plexus, is a largely unexplored brain barrier in drug delivery. • Extracellular vesicles hold great potential as drug delivery vehicle. • Choroid plexus epithelial cell-derived extracellular vesicles home to the brain and choroid plexus. • Choroid plexus epithelial cell-derived extracellular vesicles functionally deliver cargo to astrocytes and microglia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=159928484
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.biomaterials.2022.121830
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Extracellular vesicles
        Type: general
      – SubjectFull: Blood-brain barrier
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Choroid plexus
        Type: general
      – SubjectFull: Choroid
        Type: general
      – SubjectFull: Central nervous system
        Type: general
    Titles:
      – TitleFull: Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pauwels, Marie J.
      – PersonEntity:
          Name:
            NameFull: Xie, Junhua
      – PersonEntity:
          Name:
            NameFull: Ceroi, Adam
      – PersonEntity:
          Name:
            NameFull: Balusu, Sriram
      – PersonEntity:
          Name:
            NameFull: Castelein, Jonas
      – PersonEntity:
          Name:
            NameFull: Van Wonterghem, Elien
      – PersonEntity:
          Name:
            NameFull: Van Imschoot, Griet
      – PersonEntity:
          Name:
            NameFull: Ward, Andrew
      – PersonEntity:
          Name:
            NameFull: Menheniott, Trevelyan R.
      – PersonEntity:
          Name:
            NameFull: Gustafsson, Oskar
      – PersonEntity:
          Name:
            NameFull: Combes, Francis
      – PersonEntity:
          Name:
            NameFull: EL Andaloussi, Samir
      – PersonEntity:
          Name:
            NameFull: Sanders, Niek N.
      – PersonEntity:
          Name:
            NameFull: Mäger, Imre
      – PersonEntity:
          Name:
            NameFull: Van Hoecke, Lien
      – PersonEntity:
          Name:
            NameFull: Vandenbroucke, Roosmarijn E.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 01429612
          Numbering:
            – Type: volume
              Value: 290
          Titles:
            – TitleFull: Biomaterials
              Type: main
ResultId 1